Focused Ultrasound Therapy

Clinical Trials SquareFocused ultrasound is an early-stage, noninvasive, therapeutic technology with the potential to improve the quality of life and decrease the cost of care for patients with hyperplasia of the vulva, which is most often squamous cell, but there are variants. This novel technology focuses beams of ultrasound energy precisely and accurately on targets in the body without damaging surrounding normal tissue. See also “Vulvar Dystrophy.” 

How it Works
Where the beams converge, focused ultrasound produces precise ablation (thermal destruction of tissue) enabling hyperplastic cells to be treated without surgery.

The primary options for treatment of hyperplasia of the vulva include medication and sometimes invasive surgery.

For certain patients, focused ultrasound could provide a noninvasive alternative to surgery with less risk of complications – such as surgical wound healing or infection – at a lower cost.  Focused ultrasound can reach the desired target without damaging surrounding tissue and can also be repeated, if necessary.

Clinical Trials

At the present time, there are no clinical trials recruiting patients for focused ultrasound treatment of hyperplasia of the vulva.

Regulatory Approval and Reimbursement

This treatment has been approved by the NMPA in China. Focused ultrasound treatment for hyperplasia of the vulva is not yet approved by other regulatory bodies or covered by medical insurance companies.

Notable Papers

Feng T, Wang L, Zhu D, Wu Y, Xie J, Fang L, Du X. Factors influencing the clinical efficacy of high-intensity focused ultrasound in the treatment of non-neoplastic epithelial disorders of the vulva: a retrospective observational study. Int J Hyperthermia. 2021;38(1):1457-1461. doi: 10.1080/02656736.2021.1985628.

Krapf JM, Mitchell L, Holton MA, Goldstein AT. Vulvar Lichen Sclerosus: Current Perspectives. Int J Womens Health. 2020 Jan 15;12:11-20. doi: 10.2147/IJWH.S191200. eCollection 2020.

Ye M, Deng X, Mao S, Xue M. High intensity focused ultrasound treatment for non-neoplastic epithelial disorders of the vulva: Factors affecting effectiveness and recurrence. Int J Hyperthermia. 2015;31(7):771-6. doi: 10.3109/02656736.2015.1053101. Epub 2015 Sep 14.

Liming Ruan, Zhenwei Xie , Huiyun Wang, Jingyi Jiang , Haiyan Shi , Jian Xu. High‐intensity focused ultrasound treatment for non‐neoplastic epithelial disorders of the vulva. Intl J of gyn/OB. First published: 13 February 2010

Click here for additional references from PubMed.

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