Home Diseases and Conditions Hypertension

Hypertension

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Development Stage

Early Stage

Focused ultrasound research is in the laboratory phase and is not yet available for patients.

Clinical Trials

Focused ultrasound for this condition is being researched in clinical trials.

International Approval

Focused ultrasound is approved to treat this condition outside the US. Patients can seek commercial treatment at participating international sites.

FDA Approved

The US Food and Drug Administration has approved focus ultrasound for this condition. Patients can seek commercial treatment at participating sites.

Early Stage

Clinical Trials

International

FDA Approved

Focused ultrasound is approved to treat this condition outside the US. Patients can seek commercial treatment at participating international sites. There are also clinical trials that may be of interest to patients.

Focused Ultrasound Therapy

Focused ultrasound is a noninvasive, therapeutic technology with the potential to improve the quality of life and decrease the cost of care for patients with hypertension. This novel technology focuses beams of ultrasonic energy precisely and accurately on renal nerves or other nervous tissues without damaging surrounding normal tissue.

How it Works
Where the beams converge, the ultrasound produces precise ablation (thermal destruction) of the nerves which cause hypertension. Much of this work has been in renal nerves, but other nerves have also been studied. Another way being pursued is to use barbiturate loaded nanoparticles, which in animal models can enhance the GABA pathway and improve hypertension control.

Advantages
The primary options for treatment of hypertension include medication, but many have side effects which limit therapy effectiveness.

For certain patients, focused ultrasound could provide a noninvasive and potentially more effective alternative to current medical management. Focused ultrasound is noninvasive, so it may be able to help lower blood pressure without the side effects of medication. It can also be repeated, if necessary.

Clinical Trials

There is one clinical trial in Nanjing that is treating patients with hypertension. 

There is a clinical trial in Suzhou that is treating patients with hypertension. 

The Foundation updates these pages regularly, but with the increasing number of clinical trials, we want to be sure that our audience has the latest information available. Therefore, we also added the website search information for the above trials. If you click here, it will take you to the latest information available from https://www.clinicaltrials.gov/.  

Regulatory Approval and Reimbursement

Focused ultrasound treatment for hypertension has the CE Mark in Europe. It has not been approved by the FDA and is not covered by medical insurance companies in the US.

Notable Papers

Lea-Banks H, Chauhan N, Hynynen K. Investigating the hypotensive effect of focused ultrasound neuromodulation and barbiturate-loaded nanodroplets in healthy and hypertensive rats. Brain Stimul. 2024 Nov-Dec;17(6):1317-1327. doi: 10.1016/j.brs.2024.12.002. Epub 2024 Dec 4.PMID: 39643112  

Jiang X, Yu W, Chen Z, Li C, Li X, Xu Y, Li F, Gao H, Qian J, Xiong B, Rong S, Chen G, She Q, Huang J. Low-intensity focused ultrasound combined with microbubbles for non-invasive downregulation of rabbit carotid body activity in the treatment of hypertension. Hypertens Res. 2024 Nov;47(11):3182-3192. doi: 10.1038/s41440-024-01904-3. Epub 2024 Sep 19. PMID: 39300302 

Takei Y. Downregulation of carotid body activity using low-intensity focused ultrasound: a potential treatment option for refractory hypertension. Hypertens Res. 2024 Oct 28. doi: 10.1038/s41440-024-01977-0. PMID: 39468315 

Jiang X, Yu W, Chen Z, Li C, Li X, Xu Y, Li F, Gao H, Qian J, Xiong B, Rong S, Chen G, She Q, Huang J. Low-intensity focused ultrasound combined with microbubbles for non-invasive downregulation of rabbit carotid body activity in the treatment of hypertension. Hypertens Res. 2024 Sep 19. doi: 10.1038/s41440-024-01904-3. PMID: 39300302 

Camafort M, Ihm SH, Ruilope LM. Renal denervation for the treatment of hypertension and kidney disease. Curr Opin Nephrol Hypertens. 2023 Nov 1;32(6):544-550. doi: 10.1097/MNH.0000000000000928. Epub 2023 Sep 13. PMID: 37706512 

Li D, Cao F, Han J, Wang M, Lai C, Zhang J, Xu T, Bouakaz A, Wan M, Ren P, Zhang S. The sustainable antihypertensive and target organ damage protective effect of transcranial focused ultrasound stimulation in spontaneously hypertensive rats. J Hypertens. 2023 May 1;41(5):852-866. doi: 10.1097/HJH.0000000000003407. Epub 2023 Mar 2. PMID: 36883470 

Click here for additional references from PubMed.