A research team led by Isabelle Aubert, PhD, published a study showing that focused ultrasound increased delivery of a growth factor and improved cognition in a preclinical model of Alzheimer’s disease.
The Canadian Academy of Health Sciences also recently elected Dr. Aubert to its group of 2022 Fellows.
Dr. Aubert is a senior scientist at Sunnybrook Research Institute in Toronto.
This article provides a preclinical and clinical overview of using low-intensity ultrasound plus microbubbles to disrupt the blood-brain barrier for the delivery of immunotherapies in Alzheimer’s disease.
It then compares in vitro and in vivo models, strategies for combining therapeutic agents with microbubbles, and techniques to understand observable bioeffects.
The authors discuss questions on how in vitro studies can be translated to animal and human applications.
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