Home Diseases and Conditions Ventricular Tachycardia and Fibrillation

Ventricular Tachycardia and Fibrillation

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Development Stage

Early Stage

Focused ultrasound research is in the laboratory phase and is not yet available for patients.

Clinical Trials

Focused ultrasound for this condition is being researched in clinical trials.

International Approval

Focused ultrasound is approved to treat this condition outside the US. Patients can seek commercial treatment at participating international sites.

FDA Approved

The US Food and Drug Administration has approved focus ultrasound for this condition. Patients can seek commercial treatment at participating sites.

Early Stage

Clinical Trials

International

FDA Approved

Focused ultrasound research for this condition is in the laboratory phase and is not yet available for patients.

Focused Ultrasound Therapy

Focused ultrasound is a noninvasive, therapeutic technology with the potential to improve the quality of life and decrease the cost of care for patients with ventricular tachycardia. This novel technology focuses beams of ultrasound energy precisely and accurately on targets deep in the body without damaging surrounding normal tissue.

How it Works
Where the beams converge, focused ultrasound can produce precise ablation (thermal destruction) of the malfunctioning tissue that is causing the ventricular tachycardia. Another option is to ablate the stellate ganglion, as this elevates the threshold for ventricular fibrillation. Both of these steps are accomplished noninvasively. These preclinical projects have been recently accomplished, but it will take further studies before clinical use can occur.

Advantages
The primary options for treatment of ventricular tachycardia include medication and invasive surgical procedures.

For certain patients, focused ultrasound could provide a noninvasive alternative to surgery with less risk of complications – such as surgical wound healing or infection – at a lower cost. Focused ultrasound can also reach the desired target without damaging surrounding tissue, and it can be repeated, if necessary.

Clinical Trials

At the present time, there are no clinical trials recruiting patients for focused ultrasound treatment of ventricular tachycardia.

The Foundation updates these pages regularly, but with the increasing number of clinical trials, we want to be sure that our audience has the latest information available. Therefore, we also added the website search information for the above trials. If you click here, it will take you to the latest information available from https://www.clinicaltrials.gov/

Regulatory Approval and Reimbursement

Focused ultrasound treatment for ventricular tachycardia is not yet approved by regulatory bodies or covered by medical insurance companies.

Notable Papers

Xiang C, Cheng Y, Yu X, Mao T, Luo H, Hu H, Wu Y, Sang R, Wang Z, Wang Y, Luo Q, Huang J, Zhao J, Wang J, Wang X, Chen M, Liu W, Zhou L, Wang S, Jiang H. Low-intensity focused ultrasound modulation of the paraventricular nucleus to prevent myocardial infarction-induced ventricular arrhythmia. Heart Rhythm. 2023 Nov 30:S1547-5271(23)02976-4. doi: 10.1016/j.hrthm.2023.11.026. PMID: 38042443 

Wang S, Li B, Li X, Wu L, Zhu T, Zhao D, Jiang H. Low-intensity ultrasound modulation may prevent myocardial infarction induced sympathetic neural activation and ventricular arrhythmia. J Cardiovasc Pharmacol. 2020 Feb 17. doi: 10.1097/FJC.0000000000000810.

Yao Y, Qian J, Rong S, Huang Y, Xiong B, Yang G, Zhang D, Deng S, Tan J, Zhu Q, Deng C, Liu D, Ran H, Wang Z, Huang J. Cardiac Denervation for Arrhythmia Treatment with Transesophageal Ultrasonic Strategy in Canine Models. Ultrasound Med Biol. 2019 Feb;45(2):490-499. doi: 10.1016/j.ultrasmedbio.2018.10.013. Epub 2018 Dec 6.

Lü F, Huang W, Benditt DG. A feasibility study of noninvasive ablation of ventricular tachycardia using high-intensity focused ultrasound. J Cardiovasc Electrophysiol. 2018 May;29(5):788-794. doi: 10.1111/jce.13459. Epub 2018 Mar 6.

Click here for additional references from PubMed.