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Key Points The Focused Ultrasound Foundation sponsored the second Gordon Research Conference (GRC) on In Vivo Ultrasound Imaging, which was held August 25–30 in Waterville Valley, New Hampshire.  Researchers highlighted diverse applications of focused ultrasound, including neuromodulation, sonogenetics, immunotherapy, and regenerative medicine.  The theme of the 2024 In Vivo Ultrasound Imaging GRC meeting, held every two years, was “Advances in Translational Applications of Imaging in Disease Diagnosis, Staging and Therapy.” The meeting presented the latest developments in both therapeutic and diagnostic ultrasound technologies and was designed to foster collaboration between scientists of all career levels. Set at a remote resort in Waterville Valley, New Hampshire, it featured ample time for discussion. Focused ultrasound was featured prominently in sessions on neuromodulation, sonogenetics, immunotherapy, and ultrasound therapy.   “This was a truly fabulous meeting, offering great opportunities for faculty and trainees alike to network and develop new collaborations in a relaxed environment,” said invited speaker Natasha Sheybani, PhD, of the University of Virginia. “Topics at the meeting spanned ultrasound imaging and therapy, with an outstanding line-up of talks that gave way to provocative and enriching scientific discussions.”  Focused Ultrasound Presentations  Neuromodulation Session led by Charles Caskey, Vanderbilt University  Ultrasonic Neuromodulation in Humans by Lennart Verhagen, Radboud University  Bringing Transcranial Ultrasound Stimulation into Focus by Kim Butts Pauly, Stanford University  Biomolecular Ultrasound for Imaging and Control of Cellular Function by Mikhail Shapiro, California Institute of Technology  Ultrasound Imaging and Therapy in Immunotherapy Session led by Tatiana Khoklova, University of Washington  Imaging and Control of Immune Cell Trafficking and Function with Ultrasound by Costas Arvanitis, Georgia Institute of Technology  Ultrasound for Immuno-Modulation and Immunotherapy Delivery in Solid Cancers by Natasha Sheybani, University of Virginia  Ultrasound Control of Genetics and Epigenetics for Cell Therapy by Peter Yingxiao Wang, University of Southern California  Ultrasound Therapy Session led by Hong Chen, Washington University in St. Louis Microenvironmental Cues in Ultrasound-Responsive Hydrogel Composites Drives Tissue Regeneration by Mario Fabiilli, University of Michigan  Image-Guided Focused Ultrasound Therapy for Diseased and Aging Brains by Tao Sun, Northeastern University  Focused Ultrasound Posters  Ultrasound-Mediated Gene Therapy: Pre-Sensitization to Cure by Anubhuti Bhalotia, Case Western Reserve University  Ultrasound-Guided Selective Occlusion of Uteroplacental Blood Vessels in the Mouse Alters Fetal and Placental Development by Sarah Debebe, Hospital for Sick Children  Comparing the Delivery of Free and Liposomal Doxorubicin Across the Blood-Brain Barrier with Focused Ultrasound by Stecia-Marie Fletcher, Brigham and Women’s Hospital / Harvard Medical School  In Vivo Two-Photon Microscopy Imaging of Focused Ultrasound-Mediated Glymphatic Transport in the Mouse Brain by Yan Gong, Washington University in St. Louis  Automated Tumor and FUS Lesion Quantification on a Multi-Frequency Harmonic Motion and B-Mode Imaging Using Multi-Modality Neural Networks by Shiqi Hu, Columbia University  Acoustofluidic Delivery of Biomolecules to T Cells: A Novel Approach for Production of Immunotherapies by Jonathan Kopechek, University of Louisville  Detection of Tumor Stiffness and Vasculature Changes Using Harmonic Motion Imaging and Ultrasound Localization Microscopy Following Contrast-Enhanced Power-Doppler-Guided Sonoporation by Yangpei Liu, Columbia University  Transparent Ultrasound Transducer Platform Enables Multimodal In Vitro and In Vivo Investigations of Ultrasound Neuromodulation by Shubham Mirg, Columbia University  TRPC6 Is a Mechanosensitive Channel Essential for Ultrasound Neuromodulation in Mammalian Brain by Yuichi Takeuchi, Kindai University  Ultrasound Programmable Hydrogen-Bonded Organic Frameworks for Sono-Chemogenetics by Huiliang Wang, University of Texas at Austin  Search the Meeting Program