Meeting Report: IEEE International Ultrasonics Symposium 2023

Published:

Key Points

  • The 61st IEEE International Ultrasonics Symposium (IEEE IUS) was held September 3–8, 2023, in Montreal, Quebec, Canada. 
  • At least 85 of the meeting’s lectures and posters are of interest to the focused ultrasound community.

The 61st IEEE International Ultrasonics Symposium (IEEE IUS) was held September 3–8, 2023, in Montreal, Quebec, Canada. As a premier platform for researchers, engineers, and practitioners to exchange ideas and explore advances in ultrasonics technology, the 1,500 IEEE IUS attendees (1,200 in person, 300 virtual) learned about latest research findings and technological innovations in ultrasonics for health care, materials science, and engineering. The event serves as a catalyst for driving progress and shaping the future of ultrasonics technology and provided networking and collaboration opportunities among participants from academia, industry, and government agencies.

Frédéric Padilla, PhD, the Foundation’s Research Director for Applied Physics, attended the conference in person. “With seven parallel sessions, there was always at least one on therapeutic ultrasound, and there were also approximately 600 posters to review,” said Dr. Padilla. “I was also pleased to see a scientist from the US Food and Drug Administration promoting the use of our Therapeutic Ultrasound Reporting Guidelines Recommendations during one of the short courses.”

The Foundation sponsored an exhibit booth at the large meeting, which includes ultrasonic imaging, therapeutic ultrasound, biomedical applications that address healthcare challenges, acoustic microscopy and metrology, and ultrasonic sensors and devices. In the therapeutic ultrasound section, focused ultrasound topics included targeted drug delivery, tissue ablation, and noninvasive treatments. Presentations highlighted progress in optimizing treatment protocols, improving targeting accuracy, and minimizing side effects, paving the way for more effective therapeutic interventions.

Thought leaders shared insights into emerging trends and future directions in ultrasonics research, including the integration of artificial intelligence (AI) and machine learning for data analysis, the development of miniaturized devices for point-of-care diagnostics, and the exploration of novel transducer materials and fabrication methods.

The following 85 lectures and posters will be of interest to the focused ultrasound community (search words included HIFU, LIFU, LIPUS, focused ultrasound, and histotripsy). Additional topics, especially specific types of technical research, can be found by searching the program guide.

Elisa Konofagou, PhD, co-chaired the meeting, and Nir Lipsman, MD, PhD, gave an invited talk titled, “MR-Guided Focused Ultrasound in the Human Brain: Lessons Learned from Early Clinical Trials.”

Meaghan O’Reilly, PhD, and David Melodelima, PhD, taught a short course titled, “Therapeutic Applications of Focused Ultrasound: From Biophysics to Clinical Application.”

Short Courses

  • Therapeutic Applications of Focused Ultrasound: From Biophysics to Clinical Application by Meaghan O’Reilly and David Melodelima
  • Hydrophone Measurements for Biomedical Ultrasound Applications by Andrew Hurrell, Sam Howard, Peter Lewin, Srinath Rajagopal, Keith Wear, and Volker Wilkins.
  • All of the short courses are described at https://2023.ieee-ius.org/short-courses.

Lectures

Session A1L-03: MCA: Therapy and Drug Delivery. Chair(s): Klazina Kooiman (Erasmus)

  • An Optical and Acoustic Investigation of Size-Isolated Bubble Behavior in Small Channels Under Therapeutic Ultrasound Conditions by Xiaoxiao Zhao2, Amin Sojahrood1, Alex Wright1, and David Goertz2 from 1Sunnybrook Research Institute, Canada; and the 2University of Toronto, Canada
  • Intravital Imaging of Focused Ultrasound–Stimulated Nanodroplets in Tumour Microvasculature by Carly Pellow2, Amin Jafari Sojahrood2, Xiaoxiao Zhao2, Michael Kolios3, Agata Exner1, and David Goertz2 from 1Case Western Reserve University, USA; 2Sunnybrook Research Institute, Canada; and 3Toronto Metropolitan University, Canada

Session A3L-03: MTN: Theranostic Treatment Monitoring. Chair(s): Tali Ilovitsh (Tel-Aviv University), Raag Airan (Stanford University)

  • Assessment of the Focused Ultrasound Induced Thermal Lesion Size Using Multi-Frequency Single Transducer Harmonic Motion Imaging by Md Murad Hossain, Xiaoyue Li, Yueying Qiu, and Elisa Konofagou from Columbia University, New York, USA
  • Monitoring of Tissue Coagulation Treated by Continuous HIFU with Pulse Inversion Shear Wave Elastography by Wei-Cheng Hsiao and Bao-Yu Hsieh from Chang Gung University, Taiwan

Session A5L-01: Invited Session: Advances in Clinical Ultrasound. Chair(s): Elisa Konofagou (Columbia University)

  • MR-Guided Focused Ultrasound in the Human Brain: Lessons Learned from Early Clinical Trials by Nir Lipsman from Sunnybrook Health Sciences Centre, Canada

Session A5L-03: MTH: Cavitation Based Therapy Chair(s): Zhen Xu (University of Michigan), Mathieu Pernot (INSERM)

  • Degrading Blood Clots by Histotripsy within Millimeter Size Hollow Cylindrical Transducers for Use in Enhancing Aspiration Thrombectomy by Li Gong2, Alex Wright1, Kullervo Hynynen1, and David Goertz1 from 1Sunnybrook Research Institute, Canada; and the 2University of Toronto, Canada
  • Volumetric Nanodroplets-Enhanced Ultrasound Surgery Combined with Immunotherapy as a Cancer Therapy Platform by Bar Glickstein and Tali Ilovitsh from Tel Aviv University, Israel
  • Ultrasonic Cavitation–Enhanced Stem Cells Transplantation to Improve Prognosis of Ischemic Stroke by Wei Dong2, Guihu Wang2, Wenjuan Li2, Yingxue Liang2, Heyuan Liu2, Mingxi Wan1, Yujin Zong1, and Zongfang Li2 from the 1School of Life Science and Technology at Xi’an Jiaotong University, China; and 2The Second Affiliated Hospital, Xi’an Jiaotong University, China
  • Grey and White Matter Focused Ultrasound–Mediated Blood-Brain Barrier Opening in a Porcine Model by Alessandro De Maio2, Yuexi Huang1, Fa-Hsuan Lin2, Greg Stanisz2, and Meaghan O’Reilly2 from 1Sunnybrook Research Institute, Canada; and the 2University of Toronto, Canada
  • Transcriptomic Investigation of Bioeffects from Microbubble and Focused Ultrasound–Assisted Blood-Brain Barrier Disruption by Jane Song2, Payton Martinez2, Kangho Song2, Francis Garay1, Toni Mufford1, Adam Green1, Nataile Serkova1, and Mark Borden2 from the 1University of Colorado Anschutz Medical Campus, Colorado, USA; and the 2University of Colorado Boulder, Colorado, USA

Session B1L-03: MTH: Drug Delivery. Chair(s): Kullervo Hynynen (University of Toronto)

  • Ultrasound-Enhanced Delivery of Urolithin a Alleviated Motor Dysfunction in a Transgenic Mouse Model of Amyotrophic Lateral Sclerosis by Kaili Chen, Yiluo Xu, Ji Zhang, Xin Chen, Siping Chen, Yanyan Yu, and Yuanyuan Shen from Shenzhen University, China
  • Focused Acoustic Vortex–Mediated Sonochemotherapy for the Amplification of Immunogenic Cell Death Combined with Checkpoint Blockade to Potentiate Cancer Immunotherapy by Zhen Ya, Shifang Guo, Yan Li, Mingting Zhu, Yujin Zong, and Mingxi Wan from the School of Life Science and Technology at Xi’an Jiaotong University, China
  • Evaluation of Immune Activation of Drug-Loaded Oxygen Microbubbles Induced Vascular Normalization in Pancreatic Cancer by Yi Jia Zhou and Yi Ju Ho from National Yang Ming Chiao Tung University, Taiwan
  • LIPUS Promotes Chitosan and Prussian Blue Nanoparticle Absorption for Tissue Elasticity Recovery in Rats with Acute Tendon Injury by Qian Zheng1, Mengyao Liu2, Lixin Jiang2, and Dean Ta1 from 1Fudan University, China; and 2Shanghai Jiao Tong University, China
  • Noninvasive Pulsed Ultrasound–Enhanced Exogenous Nucleic Acid Delivery Using Cationic Nanodroplets for Ischemic Stroke Therapy by Wei Dong2, Guihu Wang2, Yingxue Liang2, Wenjuan Li2, Heyuan Liu2, Zongfang Li2, Mingxi Wan1, and Yujin Zong1 from the 1School of Life Science and Technology at Xi’ an Jiaotong University, China; and 2The Second Affiliated Hospital at Xi’an Jiaotong University, China

Session B1L-05: PGP: General Physical Acoustics II. Chair(s): Ji Wang (Ningbo University)

  • Passive and Active Cavitation Detection Methods: Inception and Persistence During HIFU Sonication by Gonzalo Garay, Yamil Abraham, Guillermo Cortela, Nicolás Benech, and Carlos Negreira from Facultad de Ciencias, UdelaR, Uruguay

Session B3L-03: MBE: Stimulatory and Therapeutic Bioeffects. Chair(s): Keith Wear (Food and Drug Administration)

  • Focused Ultrasound–Mediated Effect on the Blood–Cerebrospinal Fluid Barrier and its Impact in Reduction of Alzheimer’s Pathology by Daniella Jimenez, Alina Kline-Schoder, Fotis Tsitsos, and Elisa Konofagou from Columbia University, USA
  • Low-Intensity Pulsed Ultrasound Stimulation as a Disruptive Liquid Biopsy Approach for Ulcerative Colitis Diagnosis by Andrea Cafarelli5, Samuel Elias Pineda Chavez2, Giulia Rizzo2, Angela Sorriento5, Laura Loy1, Arianna Dal Buono1, Roberto Gabbiadini1, Lisa Meanti3, Mariangela Allocca4, Silvio Danese4, Alessandro Repici2, and Alessandro Armuzzi2, from Leon 1Humanitas Clinical and Research Center, Italy; 2Humanitas University, Italy; 3IRCCS Humanitas Research Hospital, Italy; 4IRCCS Ospedale San Raffaele, Italy; and 5Scuola Superiore Sant’Anna, Italy
  • In Vivo Two-Photon Microscopy Imaging of Focused Ultrasound–Mediated Glymphatic Transportation in the Mouse Brain by Yan Gong, Dezhuang Ye, Kevin Xu, Yaoheng Yang, and Hong Chen from Washington University in St. Louis, USA
  • Induction of a Torpor-Like Hypothermic and Hypometabolic State in Rodents by Ultrasound from Yaoheng Yang2, Jinyun Yuan2, Rachael Field3, Dezhuang Ye2, Zhongtao Hu2, Kevin Xu2, Lu Xu2, Yan Gong2, Yimei Yue2, Alexxai Kravitz3, Michael Bruchas1, Jianmin Cui2, Jonathan Brestoff3, and Hong Chen2 from the 1University of Washington, USA; 2Washington University in St. Louis, USA; and 3Washington University School of Medicine, USA
  • Histotripsy Immunotherapy Combination for the Treatment of Murine Pancreatic Tumors by Reliza McGinnis, Jadyn James, Tejaswi Worlikar, Zhuwen Wang, Amanda Huber, Michael Green, and Zhen Xu from the University of Michigan, USA

Session B3L-07: TMU: Capacitive Micromachined Ultrasonic Transducers. Chair(s): Dominique Certon (Francois Rabelais University of Tours), Erik Vilain Thomsen (Technical University of Denmark)

  • Experimental Validation of a Dual-Mode Ultrasound-Guided HIFU (USgHIFU) CMUT Probe Developed for Targeted Endocavitary Focal Therapies by Ivan Suarez-Castellanos3, Guillaume Vanstaevel3, Antoine Bienassis3, Geoffroy De Sallmard2, Bruno Giammarinaro3, Thomas Payen1, Jean-Yves Chapelon3, Nicolas Guillen1, Nicolas Sénégond4, and William Apoutou N’Djin3 from 1EDAP TMS, France; 2Hospices Civils de Lyon, France; 3LabTAU – INSERM U1032, France; and 4Vermon, France

Session B4L-03: MTH: Neuromodulation. Chair(s): Hairong Zheng (Shenzhen Institutes of Advanced Technology)

  • High-Throughput Ultrasound Neuromodulation in Awake and Freely Behaving Rats by Tommaso Di Ianni, Keith Murphy, Luis de Lecea, and Raag Airan from Stanford University, USA
  • Non-Invasive Ultrasound Stimulation of the Sciatic Nerve for the Treatment of Pain by Xiaoyan Chen, Wei Zhou, Jinpeng Li, Wen Meng, Pengqi Li, Zhengrong Lin, Long Meng, Lili Niu, and Hairong Zheng from Shenzhen Institutes of Advanced Technology, China
  • Displacement and Cavitation Monitoring During Focused Ultrasound Neuromodulation of the Sciatic Nerve in Vivo by Erica McCune, Stephen Lee, Seongyeon Kim, and Elisa Konofagou from Columbia University, USA
  • Investigation of Hemodynamic Responses Induced by Peripheral and Central Focused Ultrasound Stimulation by Seongyeon Kim, Stephen Lee, and Elisa Konofagou from Columbia University, USA
  • Exploration of Biomechanisms Regulating Single-Pulse Focused Ultrasound–Evoked Ca2+ Signaling by Ivan Suarez-Castellanos3, Tom Aubier3, Magali Perier3, Alexandre Carpentier1, Sandrine Parrot2, and William Apoutou N’Djin3 from 1AP-HP, France; 2CRNL, France; and 3LabTAU – INSERM U1032, France

Session B6L-03: MTN: Image-Guided Theranostics. Chair(s): Himanshu Shekhar (Indian Institute of Technology Gandhinagar), Geoffrey Luke (Dartmouth College)

  • Evaluating the Accuracy and Precision of Blood-Brain Barrier Opening by Using Neuronavigation-Guided FUS in Alzheimer’s Disease Patients by Sua Bae, Antonios Pouliopoulos, Robin Ji, Keyu Liu, Sergio Jiménez-Gambín, Omid Yousefian, Maria Murillo, Danae Kokossis, Lawrence Honig, and Elisa Konofagou from Columbia University, USA
  • First-in-Human Prospective Trial of Sonobiopsy in Glioblastoma Patients Using Neuronavigation-Guided Focused Ultrasound by Lu Xu2, Jinyun Yuan2, Chih-Yen Chien2, Yaoheng Yang2, Yimei Yue2, Siaka Fadera2, Andrew Stark2, Katherine Schwetye4, Arash Nazeri5, Rupen Desai3, Umeshkumar Athiraman1, Aadel Chaudhuri2, Hong Chen2, and Eric Leuthardt2 from the 1Department of Anesthesia at Washington University School of Medicine, USA; the 2Department of Biomedical Engineering at Washington University in St. Louis, USA; the 3Department of Neurosurgery at Washington University School of Medicine, and more.
  • Combination of Lateral Beam Steering and Axial Focusing Significantly Increases Theranostic Ultrasound–Mediated Blood-Brain Barrier Opening Volume and Viral Gene Delivery In Vivo by Alec Bats, Fotis Tsitsos, Rebecca Noel, Robin Ji, and Elisa Konofagou from Columbia University, USA
  • Real-Time Guidance and Characterization of Transcranial Focused Ultrasound Exposure by Abhishek Sahoo, Owen Seavey, Huijing He, David Darrow, Clark Chen, and Emad Ebbini from the University of Minnesota, USA
  • A Single Linear Array for Simultaneous Blood-Brain Barrier Opening and Cavitation Mapping in Non-Human Primates by Robin Ji, Sua Bae, Sergio Jiménez Gambín, Alec Bats, and Elisa Konofagou from Columbia University, USA

Session C1L-07: MSD: Systems for Imaging and Therapy Monitoring. Chair(s): Arun Kumar Thitai (Indian Institute of Technology Madras), Mami Matsukawa (Doshisha University)

  • Passive Acoustic Detection System for Focused Ultrasound Device Quality Assurance and Treatment Monitoring in Glioblastoma Patients by Chih-Yen Chien2, Lu Xu2, Jinyun Yuan2, Yaoheng Yang2, Yimei Yue2, Siaka Fadera2, Andrew H. Stark2, Katherine E. Schwety4, Arash Nazeri6, Rupen Desai3, Umeshkumar Athiraman1, Aadel A. Chaudhuri5, Hong Chen2, and Eric C. Leuthardt3 from the 1Department of Anesthesia at Washington University School of Medicine, USA; the 2Department of Biomedical Engineering at Washington University in St. Louis, USA; the 3Department of Neurosurgery at Washington University School of Medicine, USA; the 4Department of Pathology and Immunology at Washington University School of Medicine, USA; the 5Department of Radiation Oncology at Washington University School of Medicine, USA; and 6Mallinckrodt Institute of Radiology at Washington University School of Medicine, USA

Session C3L-03: MPA: Imaging Therapy. Chair(s): Russell Wite (University of Arizona)

  • Ultrasound and Photoacoustic Image-Guided Micro-Histotripsy for Non-Invasive Surgery by Joy Wang2, Pradyumna Kedariseti2, Mathew Mallay1, Jeffrey Woodacre1, Jeremy Brown1, Frank Wuest2, and Roger Zemp2 from 1Dalhousie University, Canada; and the 2University of Alberta, Canada

Session C4L-01: MBB: Novel Beamforming Approaches. Chair(s): Alessandro Ramalli (University of Florence), Moein Mozaffarzadeh (Radboud University Medical Center)

  • Ultrasound Monitoring of Simultaneous High-Intensity Focused Ultrasound Therapy Using Minimum Peak-Sidelobe Code Excitation by Nien-Hung Wu and Che-Chou Shen from National Taiwan University of Science and Technology, Taiwan

Session C4L-03: MTN: Novel Theranostic Agents. Chair(s): Helen Mulvana (University of Strathclyde), Christian Coviello (Verasonics)

  • A Novel Strategy to Enhance Radiotherapy Efficacy: Results from the Prospective Phase I Clinical Trial of MR-Guided Focused Ultrasound Stimulated Microbubbles Treatment for Breast Cancer by Gregory Czarnota1, Danny Vesprini2, Irene Karam2, Daniel Palhares2, and Lakshmanan Sannachi1 from 1Physical Sciences, Sunnybrook Research Institute, Canada; and 2Radiation Oncology, Sunnybrook Health Sciences Centre, Canada

Session C6L-07: TTT: Miniaturized Therapeutic and Interventional Ultrasound Transducers. Chair(s): Weibao Qiu (Shenzhen Institutes of Advanced Technology), Robert Wodnicki (University of Southern California)

  • The Acoustic Lightsaber: An 8-mm Endoscope with High-Resolution Imaging and Electronically Rasterized Histotripsy by Mathew Mallay, Thomas Landry, and Jeremy Brown from Dalhousie University, Canada

Session D2L-04: NAI: Acoustic Imaging and Microscopy. Chair(s): Robert Wodnicki (University of Southern California), Jian-Xing Wu (National Chin-Yi University of Technology)

  • Focused Ultrasound Spectroscopic Study on the Effects of Local Mechanical Stimulation on Living Cells by Natsumi Fujiwara, Takaki Matsumoto, Tan Shao Ying, Akira Nagakubo, Kichitaro Nakajima, Masahiro KinoOka, and Hirotsugu Ogi from Osaka University, Japan

Session D2L-07: MTH: Therapy Devices. Chair(s): Kenneth Bader (University of Chicago)

  • Intra-Operative High Intensity Focused Ultrasound in Patients with Colorectal Liver Metastases: A Prospective Ablate-and-Resect Study in 15 Patients by David Melodelima2, Aurelien Dupre1, David Perol1, Severine Metzger1, Claire Cropet1, and Michel Rivoire1 from 1Centre Leon Berard, France; and 2LabTAU, France
  • Focused Ultrasound Hyperthermia Mediated Control of Thermal Responsive Car T Cell Activity in Breast Cancer Brain Metastasis by Chulyong Kim, Ali Zamat, Zizhen Zha, Gabe Kwong, and Costas Arvanitis from the Georgia Institute of Technology, USA
  • Low-Intensity Pulsed Ultrasound Attenuates Body Weight and Insulin Resistance in Obese Mice Induced by High-Fat Diet by Min He1, Hong Zhu2, Jingsong Dong1, and Dean Ta1 from 1Fudan University, China; and 2Shanghai Ninth People’s Hospital, China
  • In Vivo Intraoperative HIFU Ablation of the Pancreas Using a Toroidal Transducer for the Treatment of Locally Advanced Pancreatic Cancer by Celia Cilleros3, Aurélien Dupré1, Yao Chen1, Jeremy Vincenot2, Michel Rivoire1, and David Melodelima3 from 1Centre Leon Berard, France; 2EDAP-TMS, France; and 3LabTAU, France
  • Focused Ultrasound Ablation of Uterine Fibroids with a Flat Fully-Populated MR-Guided Phased Array Body System by Ryan Jones2, Yuexi Huang2, Ben Lucht1, Samuel Gunaseelan2, Tyler Portelli1, Elizabeth David2, and Kullervo Hynynen2 from 1Arrayus Technologies, Canada; and 2Sunnybrook Research Institute, Canada
  • First In-Vivo Demonstration of Hologram-Assisted Bilateral Blood-Brain Barrier Opening in Nonhuman Primates by Sergio Jiménez-Gambín, Sua Bae, Robin Ji, Fotios Tsitsos, and Elisa E. Konofagou from Columbia University, USA

Posters

Session A2P-09: MBE-P: LIPUS and Neuro. Chair(s): Julianna Simon (Penn State University)

  • A2P-09-MBE-3. Low-Intensity Pulsed Ultrasound Improves Cognitive Performance in AD Mice by Wanzhao Wang2, Liang Tang2, Lijun Sun2, Chenghui Wang3, Dean Ta1, and Jianzhong Guo3 from the 1Department of Electronic Engineering at Fudan University, China; the 2Institute of Sports Biology at Shaanxi Normal University, China; and the 3Shaanxi Key Laboratory of Ultrasonics at Shaanxi Normal University, China
  • A2P-09-MBE-4. LIPUS Alleviates Muscle Atrophy Caused by Microgravity by Improving Intestinal Microorganisms by Yanan Yu2, Liang Tang2, Lijun Sun2, Jianzhong Guo3, Dean Ta1, and Chenghui Wang3 from the 1Department of Electronic Engineering at Fudan University, China; the 2Institute of Sports Biology at Shaanxi Normal University, China; and the 3Shaanxi Key Laboratory of Ultrasonics at Shaanxi Normal University, China
  • A2P-09-MBE-5. Focused Ultrasound Blood-Brain Barrier Opening Alters Murine Microbiome by Alina Kline-Schoder, Daniella Jimenez, Samantha Gorman, and Elisa Konofagou from Columbia University, USA

Session A2P-21: MTH-P: Therapy I. Chair(s): Jon Sukovich (University of Michigan)

  • A2P-21-MTH-1. A Mechanism Limiting Bubble Density in Cavitation Clouds Generated During histotripsy by Adam Maxwell1 and Eli Vlaisavljevich2 from the 1University of Washington, USA; and 2Virginia Polytechnic Institute and State University, USA
  • A2P-21-MTH-2. Multi-Modal Confirmation of Thermosensitive Liposome Delivery to the Brain After FUS-Induced Blood-Brain Barrier Opening for the Treatment of Diffuse Midline Glioma by Chris Payne, Paul Cressey, Maya Thanou, and Antonios Pouliopoulos from Kings College London, UK
  • A2P-21-MTH-4. Development of Optically Transparent, Tendon-Mimicking Histotripsy Phantoms by Jake Elliot and Julianna Simon from Penn State University, USA
  • A2P-21-MTH-5. Shockwave Evolutions During Volumetric Histotripsy Treatment in Ex-Vivo Tissues by Scot Haskell, Jonathan Sukovich, and Zhen Xu from the University of Michigan, USA
  • A2P-21-MTH-7. Time-Resolved Passive Acoustic Mapping in Transcranial Histotripsy by Ning Lu, Jonathan Sukovich, Timothy Hall, and Zhen Xu from the University of Michigan, USA
  • A2P-21-MTH-8. Histotripsy Induced Fractionation in Collagenous Tissues: A Tendon Model by Grace Wood, Molly Smallcomb, and Julianna Simon from Penn State University, USA
  • A2P-21-MTH-9. Assessment of Histotripsy and Thrombolytic in a Porcine Model of Venous Thrombosis by Kenneth Bader, Connor Centner, Kai Flores, Allison Ostdiek, Ethan Ungchusri, Mikin Patel, Osman Ahmed, and Jonathan Paul from the University of Chicago, USA
  • A2P-21-MTH-10. MRI-Guided Focused Ultrasound Blood-Brain Barrier Opening Increases Drug Delivery and Efficacy in a Diffuse Midline Glioma Mouse Model by Payton Martinez3, Genna Nault2, Jenna Steiner2, Micheal Wempe2, Angela Pierce2, Breauna Brunt2, Mathew Slade2, Jane Song3, Kang-Ho Song3, Nicholas Ellens1, Nataile Serkova2, Adam Green2, and Mark Borden3 from 1Acertera Labs, USA; the 2University of Colorado, USA; and the 3University of Colorado Boulder, USA

Session A2P-22: MTH-P: Therapy II. Chair(s): Costas Arvanitis (Georgia Institute of Technology)

  • A2P-22-MTH-1. Focused Ultrasound-Mediated Brain Drug Delivery Through Different Routes by Dezhuang Ye, Si Chen, Yajie Liu, Charlote Weixel, Hu Zhongtao, and Hong Chen from Washington University in Saint Louis, USA
  • A2P-22-MTH-2. Ultrasound-Activated Eradication of Root Canal Biofilm with Drug-Loaded Phase Change Nanodroplets by Jie Dang1, Xiaoyu Qian1, Feihong Dong1, Jie Pan2, and Jue Zhang1 from 1Peking University, China; and 2Peking University School and Hospital of Stomatology, China
  • A2P-22-MTH-3. Process Optimization of In Vitro Sonoporation Protocol for Clinically Relevant Ultrasound-Mediated Gene Delivery by Nisi Zhang1, Yutong Guo1, Josquin Foiret1, Spencer Tumbale1, Ramasamy Paulmurugan1, Gadi Pelled2, and Katherine W. Ferrara1 from the 1Department of Radiology, Stanford University, USA; and 2Sonostem Technologies Inc., USA
  • A2P-22-MTH-4. Evaluation of the Kinetics of BBB Permeability Induced by Focused Ultrasound Using PET Imaging by Sarah Leterrier1, Sebastien Goutal1, Laurene Jourdain1, Maud Goislard1, Benoit Hosten1, Benoit Larrat2, Charles Truillet1, Nicolas Tournier1, and Anthony Novell1 from 1BioMaps, Université Paris-Saclay, CEA, CNRS, Inserm, France; and 2Neurospin, Université Paris-Saclay, CEA, CNRS, Inserm, France
  • A2P-22-MTH-5. Focused Ultrasound–Mediated Blood-Brain Barrier Opening for the Delivery of Lipid Nanoparticles in a Glioblastoma Model by Maya Elbaz3, Lea Peko1, Nitay Ad-El2, Ramona Aronovich1, Meir Goldsmith2, Inbal Halevy2, Dan Peer2, and Tali Ilovitsh3 from the 1Department of Biomedical Engineering, Israel; 2Department of Cell Research & Immunology, the Center for Nanoscience and Nanotechnology, Israel; and 3Sagol School of Neuroscience and Department of Biomedical Engineering, Israel
  • A2P-22-MTH-6. Evaluation of Ultrasound-Triggered Vancomycin Release from a Novel Prophylactic Spinal Device in an In Vivo Sheep Model by Lauren Delaney4, Rachel Hilliard2, Priscilla Machado4, Rachel Evans3, Selin Isguven3, Steven Kurtz1, Noreen Hickok3, Thomas Schaer2, and Flemming Forsberg4 from 1Drexel University Implant Research Core, USA; 2New Bolton Center University of Pennsylvania School of Veterinary Medicine, Dept of Clinical Studies, USA; 3Thomas Jefferson University Department of Orthopaedic Surgery, USA; 4Thomas Jefferson University Department of Radiology, USA
  • A2P-22-MTH-7. Double Emulsion Perfluorocarbon Nanodroplets for US/Pa-Guided Drug Delivery via High-Intensity Focused Ultrasound by Euisuk Chung, Andrew Zhao, and Stanislav Emeilanov from Georgia Institute of Technology, USA
  • A2P-22-MTH-8. Focused ultrasound–Mediated Delivery of Anti-Programmed Cell Death-Ligand 1 Antibody to the Brain of a Porcine Model by Siaka Fadera, Chinwendu Chukwu, Andrew Stark, Yimei Yue, Lu Xu, Chih-Yen Chien, Jinyun Yuan, Dezhuang Ye, and Hong Chen from Washington University in St Louis, USA
  • A2P-22-MTH-9. Enhanced Ultrasound Neurostimulation Using Piezoelectric Molybdenum Disulfide Nanosheets by Min-Hwa Chou3, Pei-Hua Chiang2, Ching-Hsiang Fan1, and Chih-Kuang Yeh2 from 1National Cheng Kung University, Taiwan; 2National Tsing Hua University, Taiwan; and 3National Tsing Hua University, Taiwan

Session A2P-23: MTN-P: Treatment Monitoring Chair(s): Piotr Kijanka (AGH University of Science and Technology)

  • A2P-23-MTN-2. Ultrasonic Nakagami Imaging for Monitoring Histotripsy-Inducing Tissue Erosion by Meng Han, Weidong Song, Fengshou Zhang, and Bianyun Cai from Henan University of Science and Technology, China
  • A2P-23-MTN-3. Monitoring of Continuous HIFU Therapy Using Nakagami Imaging Combined with Pulse Inversion Subtraction by Hsien-Jung Chan, Wei-Cheng Hsiao, Po-Hsiang Tsui, and Bao-Yu Hsieh from Chang Gung University, Taiwan
  • A2P-23-MTN-5. Phase Modulation-Based Harmonic Suppression in CMUT Transmitters for Transcranial Microbubble Monitoring by Sait Kilinc, Reza Zangabad, Hohyun Lee, Costas Arvanitis, and Levent Degertekin from Georgia Institute of Technology, USA
  • A2P-23-MTN-6. Doppler-Based Assessment of Boiling Histotripsy Progression In Vivo by Minho Song2, Gilles Thomas2, Vera Khokhlova1, YakNam Wang2, Stephanie Toten2, Oleg Sapozhnikov1, George Schade2, and Tatiana Khokhlova2 from 1M.V. Lomonosov Moscow State University, Russia; and the 2University of Washington, USA

Session B2P-08: MBB-P: Adaptive and 3D Beamforming. Chair(s): Dongwoon Hyun (Stanford University), Anand Ramkumar (Institute of Cancer Research)

  • B2P-08-MBB-9. Evaluation of Advanced Passive Acoustic Mapping (PAM) Beamformers for High-Duty-Cycle HIFU Ablated in Ex Vivo Tissue by Chunqi Li1, Thomas M. Carpenter2, David Cowell2, Steven Freear2, James McLaughlan2 from the 1Department of Biomedical Engineering, Columbia University, New York, NY, USA; and the 2School of Electronic & Electrical Engineering, Leeds, UK

Session B2P-09: MBE-P: Mechanisms and Dosimetry. Chair(s): Srinath Rajagopal (National Physical Laboratory), Volker Wilkens (PTB)

  • B2P-09-MBE-7. Blood Biopsy-Based Screening of Clinically Significant Prostate Cancer via Detection of High-Intensity Focused Ultrasound–Induced Release of miRNA from Circulating Tumor Cells by Pradyumna Kedariseti2, Joy Wang1, Samantha Leier3, Frank Wuest3, and Roger Zemp2 from the 1Department of Biomedical Engineering at the University of Alberta, Canada; the 2Department of Electrical and Computer Engineering at the University of Alberta, Canada; and the 3Department of Oncology at the University of Alberta, Canada

Session B2P-22: MTH-P: Therapy III. Chair(s): Anthony Novell (CEA)

  • B2P-22-MTH-6. Focused Ultrasound Fracture of Calcified Atherosclerotic Plaque by Adam Maxwell2, Lucas Chen2, Yak-Nam Wang2, Ga Won Kim2, Zorawar Singh2, Adrienne Lehnert2, Robert Miyaoka2, and Hitinder Gurm1 from the 1University of Michigan, USA; and the 2University of Washington, USA

Session B2P-23: MTN-P: Theranostic Agents. Chair(s): Mark Borden (University of Colorado at Boulder)

  • B2P-23-MTN-2. Enhanced Delivery of Antidepressant(escitalopram)-Liposome-Loaded Microbubbles with Focused Ultrasound for Depressive Disorders by Chen-Cheng Tasi, Chia-Wei Lin, and Chih-Kuang Yeh from National Tsing Hua University, Taiwan
  • B2P-23-MTN-3. Measuring MRI Signal of Gd-Labelled Antibodies and Liposomes for Confirming Ultrasound-Mediated Delivery Into the Brain by Hasan Koruk, Paul Cressey, Christopher Payne, Maria Thanou, and Antonios N. Pouliopoulos from King’s College London, UK

Session C2P-10: MCA-P: PAM and Microbubble Production. Chair(s): David Goertz (Sunnybrook Research Institute)

  • C2P-10-MCA-7. Passive Cavitation Imaging Using Pth Root Delay Add Sum Beamforming: In Vitro and In Vivo Feasibility Assessment for Histotripsy Guidance by Abhinav Singh1, Kai Flores2, Kenneth Bader2, and Himanshu Shekhar1 from 1Indian Institute of Technology Gandhinagar, India; and the 2University of Chicago, USA

Session C2P-12: MEL-P: Advances in Elastography Methods. Chair(s): Salavat Aglyamov (University of Houston)

  • C2P-12-MEL-1. Passive Elastography Using a CMUT-Based Device Developed for Endocavitary Ultrasound-Guided HIFU: Gel Phantoms Experiments by Bruno Giammarinaro2, Ivan Suarez-Castellanos2, Antoine Bienassis2, Guillaume Vanstaevel2, Nicolas Guillen1, Nicolas Sénégond3, Stefan Catheline2, and W. Apoutou N’djin2 from 1EDAP TMS, Vaulx-en-Velin, France; 2LabTAU, INSERM, Centre Léon Bérard, Université de Lyon, France; and 3Vermon, Tours, France

Session C2P-15: MIM-P: US Simulations and US-based Modeling. Chair(s): Yaoyao Cui (Suzhou Institute of Biomedical Engineering and Technology)

  • C2P-15-MIM-4. Evaluation of HIFU Focus Prediction Using Acoustic Radiation Force Imaging by Lian Feng, Xingwang Shi, Fang Zhou, Yanhua Chen, and Xiaowei Zhou from Chongqing Medical University, China

Session C2P-22: MTH-P: Therapy IV. Chair(s): David Melodelima (INSERM)

  • C2P-22-MTH-1. Boundary Recognition of HIFU Lesions Using Gamma for Efficient Assessment of Ultrasound Surgery by Quan Zhang, Xuan Liu, Juntao Chang, Mingzhu Lu, Yanshu Jing, Rongzheng Yang, Weihao Sun, Jie Deng, Tingting Qi, and Mingxi Wan from Xi’an Jiaotong University, China
  • C2P-22-MTH-2. Measurement of HIFU Pressures, Intensities, and Beamwidths Using Spatiotemporal Deconvolution by Keith Wear2 and Samuel Howard1 from 1Onda Corporation, USA and the 2US Food and Drug Administration, USA
  • C2P-22-MTH-5. MR-Guided Rodent Histotripsy System by Ryan Hubbard, Jonathan Sukovich, David Choi, Tejaswi Worlikar, Timothy Hall, and Zhen Xu from the University of Michigan, USA
  • C2P-22-MTH-6. Nine-French Dual-Mode Catheter for Interstitial Ultrasound-Guided Directional HIFU Thermal ablations: Experimental Validation by Thomas Biscaldi2, Romain L’Huillier1, Laurent Milot1, and W. Apoutou N’Djin2 from the 1Department of Radiology, Hospices Civils de Lyon, Lyon, France; and 2Labtau, INSERM, Centre Léon Bérard, Université de Lyon, Lyon, France
  • C2P-22-MTH-8. Assessment of Focused Ultrasound Drug Delivery Efficacy in Brain Tumors with Liquid Biopsy by Victor Menezes, Hohyun Lee, Yutong Guo, Naima Djeddar, Anton Bryksin, and Costas Arvanitis from the Georgia Institute of Technology, USA

Session C2P-23: MTN-P: Image Guidance. Chair(s): Francois Yu (University of Montreal)

  • C2P-23-MTN-2. High-Intensity Focused Ultrasound Ablation Monitoring Using Ultrafast Doppler imaging: A Preliminary Study by Shaoyuan Yan, Yapeng Fu, and Kailiang Xu from Fudan University, China
  • C2P-23-MTN-3. Real-Time Thermal Strain Imaging for Guidance and Monitoring of HIFU Treatment on an Ultrasound-Guided Focused Ultrasound (USgFUS) Therapy System by Juvenal Ormachea and Peter Kaczkowski from Verasonics Inc., USA
  • C2P-23-MTN-5. Low-Intensity Pulsed Ultrasound Accelerates Glucose Uptake in Skeletal Muscle by Zhanke Ma2, Liang Tang2, Lijun Sun2, Xiushan Fan2, Chenghui Wang3, Jianzhong Guo3, and Dean Ta1 from the 1Department of Electronic Engineering at Fudan University, China; the 2Institute of Sports Biology at Shaanxi Normal University, China; and the 3Shaanxi Key Laboratory of Ultrasonics at Shaanxi Normal University, China

Session C2P-32: TMI-P: Biomedical Transducers. Chair(s): Yongrae Roh (Kyungpook National University)

  • C2P-32-TMI-3. Transcranial Focused Ultrasound Stimulation of Periaqueductal Gray for Analgesia by Tao Zhang and Benpeng Zhu from Huazhong University of Science and Technology, China

Student Paper Competition

  • SPC-17: The Acoustic Lightsaber: An 8-mm Endoscope with High-Resolution Imaging and Electronically Rasterized Histotripsy by Matthew Mallay from Dalhousie University, Canada

Next Meeting

In 2024, the IEEE Ultrasonics, Ferroelectrics, and Frequency Control (UFFC) Joint Symposium will take place September 22–26, 2024 at the Taipei Nangang Exhibition Center in Taipei, Taiwan. The joint conference will celebrate the 70th anniversary of the IEEE UFFC Society.

See the Meeting Website

Parts of this meeting report were written with the assistance of Perplexity and ChatGPT. Perplexity pulled much of the information from the IEEE IUS Symposium Recap.