Home Diseases and Conditions Uterine Fibroids

Uterine Fibroids

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Development Stage

Early Stage

Focused ultrasound research is in the laboratory phase and is not yet available for patients.

Clinical Trials

Focused ultrasound for this condition is being researched in clinical trials.

International Approval

Focused ultrasound is approved to treat this condition outside the US. Patients can seek commercial treatment at participating international sites.

FDA Approved

The US Food and Drug Administration has approved focus ultrasound for this condition. Patients can seek commercial treatment at participating sites.

Early Stage

Clinical Trials

International

FDA Approved

Focused ultrasound treatment for uterine fibroids has been available to women in the U.S. since a treatment system was approved by the Food and Drug Administration (FDA) in 2004.

Focused ultrasound is a noninvasive way to treat uterine fibroids. Using this treatment method in conjunction with image guidance, the physician directs a focused beam of energy through the patient’s skin, superficial fat layer, and abdominal muscles to heat and destroy the fibroid tissue without damaging nearby tissue or the tissues that the beam passes through on its way to the target.

How it Works
Focused ultrasound energy heats and destroys the targeted tissue at the focal point. This process is repeated until the entire selected volume is destroyed.

Advantages

  • It is a noninvasive treatment with a short recovery time and a quick return to work and activities of normal life (usually the next day).
  • It offers rapid and durable resolution of fibroid symptoms (sometimes within days of treatment).
  • It has a low rate of complications.
  • It preserves fertility with published studies reporting that women are able to conceive and have normal pregnancies after treatment.

Get Treated

There is a multi-center clinical trial for uterine fibroids intended to capture long term outcomes. 

There is a clinical trial in China that is treating adenomyosis in patients with refractory infertility with the goal of enhancing fertility.

There is a clinical trial in the Netherlands, which is a 2:1 randomized trial comparing MRI-guided focused ultrasound to other treatments (hysterectomy, myomectomy, or uterine artery ablation). See the website for this trial, called MYCHOICE, for more information. 

There is a clinical trial in Germany, that is a randomized trial comparing MRI-guided focused ultrasound to myomectomy.

There is a clinical trial in Turku, Finland, that is using focused ultrasound to treat uterine fibroids.

The Foundation updates these pages regularly, but with the increasing number of clinical trials, we want to be sure that our audience has the latest information available. Therefore, we also added the website search information for the above trials. If you click here, it will take you to the latest information available from https://www.clinicaltrials.gov/. 

See a list of treatment sites > 
See a list of clinical trials sites >
See a list of laboratory research sites >

Regulatory Approval and Reimbursement

In 2004, MRI-guided focused ultrasound was approved by US Food and Drug Administration for the treatment of uterine fibroids. Currently, no major U.S. insurance company provides consistent coverage and reimbursement for focused ultrasound treatment of fibroids. However, Blue Cross/Blue Shield, AETNA, and United have all approved cases on an individual basis.

Internationally, focused ultrasound is approved in Canada, China, Europe, India, Japan, Korea, the Middle East, Oceania, Russia, South America, and Taiwan. 

In the United Kingdom, Germany, and Russia, individual patients have gained local level approval. In China, healthcare insurance partially or fully covers the cost of the treatment. 

In Israel, Clalit Medical Insurance is covering MRgFUS for symptomatic uterine fibroids.

Notable Papers

Li C, Liao H, Liu J, Gao J. Intratumoral and peritumoral radiomics for preoperative prediction of the efficacy of HIFU ablation for uterine fibroids based on multiparametric MRI: a multicenter study. Front Oncol. 2026 Jan 13;15:1699632. doi: 10.3389/fonc.2025.1699632. eCollection 2025. PMID: 41607533 

De Smit NS, de Lange ME, Boomsma MF, Huirnet JAF, Hehenkamp WJK. Current Treatment for Symptomatic Uterine Fibroids: Available Evidence and Therapeutic Dilemmas. Obstet Gynecol Surv. 2026 Jan 1;81(1):15-16. doi: 10.1097/OGX.0000000000001484. Epub 2026 Jan 19. PMID: 41557923 

Cui Y, Feng M, Yao L, Yan J, Li W, Huang Y. Enhancement of radiomics-based machine learning models for predicting efficacy of high-intensity focused ultrasound ablation of uterine fibroids using undersampling methods. Nan Fang Yi Ke Da Xue Xue Bao. 2026 Jan 20;46(1):141-149. doi: 10.12122/j.issn.1673-4254.2026.01.15. PMID: 41540700 

Yang MT, Tian L, Xia Y, He HN, Lin C, He TW, Tang Y, Hu HQ, Li J. Polidocanol augments high-intensity focused ultrasound efficacy for hyperintense fibroids on T2WI: a retrospective cohort study. Int J Hyperthermia. 2026 Dec;43(1):2612543. doi: 10.1080/02656736.2025.2612543. Epub 2026 Jan 12. PMID: 41521758 

Bian X, Sun Q, Ren Q, Chen G. Histogram analysis of apparent diffusion coefficient for preoperative prediction of mid-term efficacy of high-intensity focused ultrasound in the treatment of uterine fibroids. Abdom Radiol (NY). 2026 Jan;51(1):283-291. doi: 10.1007/s00261-025-05055-y. Epub 2025 Jun 16. PMID: 40522385 

Ponomarchuk E, Tsysar S, Kvashennikova A, Pestova P, Papikyan L, Kadrev A, Danilova N, Malkov P, Chernyaev A, Buravkov S, Khokhlova V. Non-thermal ultrasound-guided fractionation of human leiomyosarcoma with boiling histotripsy: an ex vivo feasibility study. Ultrasonics. 2026 Mar;159:107876. doi: 10.1016/j.ultras.2025.107876. Epub 2025 Oct 22. PMID: 41135484 

Zhang G, Wang W, Sun M, Yu X, Lang J. Volume reduction rate and its influencing factors in solitary uterine fibroids classified as Funaki types I and II after ultrasonography-guided high intensity focused ultrasound ablation: a prospective cohort study. Int J Hyperthermia. 2025 Dec;42(1):2597678. doi: 10.1080/02656736.2025.2597678. Epub 2025 Dec 14. PMID: 41392568 

Setzen R, Setzen R, O’Donoghue C, Van Dyk N, Sengane A, Manyatsi N, Sarubdeo S, Adam Y. Changes in symptoms and fibroid characteristics in women treated with ultrasound-guided high intensity focused ultrasound (USgHIFU) at Chris Hani Baragwanath Academic Hospital. Int J Gynaecol Obstet. 2025 Dec 15. doi: 10.1002/ijgo.70742. PMID: 41392873 

Xia H, Liu W, Mao H, Li C, Zu Y, Yu Y, Chen W, Zhang Y, Chen J. Delayed uterine rupture and septic shock after high-intensity focused ultrasound for uterine fibroids: a case report. Front Oncol. 2025 Dec 8;15:1697568. doi: 10.3389/fonc.2025.1697568. eCollection 2025. PMID: 41438977 

Zhou Y, Xu H, Jiang W, Zhang J, Chen S, Yang S, Xiang H, Hu W, Qiao X. A Fusion Model of ResNet and Vision Transformer for Efficacy Prediction of HIFU Treatment of Uterine Fibroids. Acad Radiol. 2025 Dec;32(12):7294-7306. doi: 10.1016/j.acra.2025.08.054. Epub 2025 Sep 10. PMID: 40935773 

Zhang D, Wu S, Ding G, Chen S. Development and validation of sonographic feature-based prediction models for ultrasound-guided HIFU ablation of uterine fibroids. Int J Hyperthermia. 2025 Dec;42(1):2563302. doi: 10.1080/02656736.2025.2563302. Epub 2025 Sep 29. PMID: 41020327 

Wang M, Zhu Q, Guan H, Zhao J, Gu P, Tang L. The Impact of High-Intensity Focused Ultrasound Ablation and Laparoscopic Myomectomy on Ovarian Function in Patients with Uterine Fibroids. Int J Womens Health. 2025 Nov 7;17:4239-4245. doi: 10.2147/IJWH.S560728. eCollection 2025. PMID: 41230039 

Liu D, Zhao M, Fan X, Li M, Yin X, Shen G, Wang H. MRI guided HIFU robotic system application in feasibility study for treating uterine fibroids. Sci Rep. 2025 Nov 19;15(1):40829. doi: 10.1038/s41598-025-24562-y. PMID: 41257947 

Zhang Q, Yan D, Zhang A, Yi S, Xiao S, Zhu S, Jiang B. Clinical comparison of high-intensity focused ultrasound versus uterine artery embolization with laparoscopic excision in type III cesarean scar ectopic pregnancy management: a retrospective cohort study. Int J Hyperthermia. 2025 Dec;42(1):2584544. doi: 10.1080/02656736.2025.2584544. Epub 2025 Nov 6. PMID: 41198145 

Wu G, He M, Ran F, Yunyun L, Fei L, Zhenghua X, Zhang X, Wang Z. Carboprost tromethamine injection enhanced the efficacy of focused ultrasound ablation surgery for hyperintense uterine fibroids: a retrospective study. Int J Hyperthermia. 2025 Dec;42(1):2552814. doi: 10.1080/02656736.2025.2552814. Epub 2025 Oct 1. PMID: 41035205 

Cao WT, Peng ZH, Wang RQ, Luo H. Advancing understanding of HIFU in uterine fibroids: A meta-review on postoperative recovery and surgical wound healing. Medicine (Baltimore). 2025 Oct 3;104(40):e42212. doi: 10.1097/MD.0000000000042212. PMID: 41054082 

Li S, He L, Tan T, Yang ZY, Deng YB, Chen JY. Comparison of reproductive outcomes after ultrasound-guided high-intensity focused ultrasound and myomectomy for patients with uterine fibroids. Int J Hyperthermia. 2025 Dec;42(1):2572358. doi: 10.1080/02656736.2025.2572358. Epub 2025 Oct 21. PMID: 41117038 

Knorren ER, Schutte JM, Huirne JAF, Boomsma MF. Understanding clinical outcomes of MR-HIFU treatment of uterine fibroids by gaining insight in screening protocols. Acta Obstet Gynecol Scand. 2025 Oct 29. doi: 10.1111/aogs.70087. PMID: 41159554 

Damiani GR, Bardi M, Vitagliano A, Perrone AM, Panico G, Vimercati A, Loizzi V, Gennaro DD, Naro ED, Cicinelli E, Malvasi A, Tinelli A, Baldini GM, Pellegri AM. Myoma expulsion after minimally invasive therapeutic strategies: a systematic review. Eur J Obstet Gynecol Reprod Biol. 2025 Sep;313:114576. doi: 10.1016/j.ejogrb.2025.114576. Epub 2025 Jul 29. PMID: 40779820 

Wei L, Tao H, Zeng D, Zhong H, Wang L, Shi Q. The association between age and re-intervention rates in uterine fibroid patients after UsgHIFU therapy: A cohort study. J Obstet Gynaecol Res. 2025 Sep;51(9):e70045. doi: 10.1111/jog.70045. PMID: 40904017 

Wu M, Li J, Huang L, Wei J, Qin H, Qin W. Assessing the Efficacy of High-Intensity Focused Ultrasound for Uterine Fibroids Using Dynamic Contrast-Enhanced-Magnetic Resonance Imaging. J Coll Physicians Surg Pak. 2025 Sep;35(9):1096-1100. doi: 10.29271/jcpsp.2025.09.1096. PMID: 40948154 

Salimi M, Abdolizadeh A, Fayedeh F, Vadipour P. Predictive Value of MRI Radiomics for the Efficacy of High-Intensity Focused Ultrasound (HIFU) Ablation in Uterine Fibroids: A Systematic Review and Meta-Analysis. Ultrasound Med Biol. 2025 Sep 29:S0301-5629(25)00353-9. doi: 10.1016/j.ultrasmedbio.2025.09.002. PMID: 41027762 

Tao SQ, Shi LY, Chai XS, Yuan XR, Tang SX, Zhang J, Bian DJ, Fu C. Value of multi-modal MRI in predicting the effect of high-intensity focused ultrasound for uterine fibroids. Int J Hyperthermia. 2025 Dec;42(1):2495360. doi: 10.1080/02656736.2025.2495360. Epub 2025 Apr 23. PMID: 40269574 

Li H, Gao Y, Zhang X, Hou W, Ma Y, Shi R, Ren P. Establishment of a Predictive Model for the Efficacy of High-Intensity Focused Ultrasound in the Treatment of Uterine Fibroids. J Ultrasound Med. 2025 Sep;44(9):1645-1656. doi: 10.1002/jum.16718. Epub 2025 May 27. PMID: 40423241 

Yang L, Liu J, Wu S, Han Y, Bai J, Shi Q. Comparison of high-intensity focused ultrasound ablation for uterine fibroids with different blood flow grading based on Alder classification. Int J Hyperthermia. 2025 Dec;42(1):2519346. doi: 10.1080/02656736.2025.2519346. Epub 2025 Jun 22. PMID: 40545838 

Wu S, Liu J, Tang Y, Yang L, Han Y. Skin burns after high-intensity focused ultrasound ablation: a retrospective control study. Sci Rep. 2025 Aug 1;15(1):28127. doi: 10.1038/s41598-025-13436-y. PMID: 40750815 

Tan T, Li S, Yang Z, Lin J, Yang M, Hu L, Chen J. Comparison of Reintervention Rates for Type 1 and Type 2 Uterine Fibroids Treated With HIFU Ablation With Varying Non-Perfused Volume Ratios to That With TCRM. J Ultrasound Med. 2025 Aug 5. doi: 10.1002/jum.70011. PMID: 40762411 

Lewis JM, Algurjia E, Lumsden MA, Meinhold-Heerlein I, Wasson MN, Spiers A, Descamps P. Image-guided therapies for uterine fibroids. Int J Gynaecol Obstet. 2025 Sep 1. doi: 10.1002/ijgo.70493. PMID: 40888469 

Wen S, Zhang D, Lei Y, Yang Y. A superpixel based self-attention network for uterine fibroid segmentation in high intensity focused ultrasound guidance images. Sci Rep. 2025 Jul 1;15(1):21970. doi: 10.1038/s41598-025-08711-x. PMID: 40595279 

Huang S, Ye M, Xi X, Li W, Zhu X, Sun X. High intensity focused ultrasound serves as a salvage treatment for uterine arteriovenous fistula when uterine artery embolization fails and pregnancy outcomes: a case report and literature review. Int J Hyperthermia. 2025 Dec;42(1):2519347. doi: 10.1080/02656736.2025.2519347. Epub 2025 Jul 14. PMID: 40654090 

Gemesi TS, Lum D, Atashroo D, Chao L. Minimally invasive and ablative therapies for symptomatic uterine fibroids: a narrative review. Curr Opin Obstet Gynecol. 2025 Jul 24. doi: 10.1097/GCO.0000000000001056. PMID: 40742981 

Hu L, Fang C, Tang N, Xu F. Comparison of the perioperative complications of high intensity focused ultrasound vs. laparoscopic surgery for uterine fibroids: a retrospective study. Front Surg. 2025 Jul 17;12:1568000. doi: 10.3389/fsurg.2025.1568000. eCollection 2025. PMID: 40746835 

Ganeau A, Charrel T, Pichot O, Lafon C. Preclinical Demonstration of In-Vivo Vein Occlusion by Mechanical HIFU Without Contrast Agent Injection: Paving the Way for the Non-Invasive Treatment of Varicose Veins. Ultrasound Med Biol. 2025 Aug;51(8):1210-1216. doi: 10.1016/j.ultrasmedbio.2025.04.004. Epub 2025 May 12. PMID: 40355312 

Su Z, Liu S, Wang J, Jin F, Peng Y, Wen J. Retrospective cohort study on the efficacy and safety of high-intensity focused ultrasound in non-invasive treatment of uterine leiomyomas and adenomyosis. Abdom Radiol (NY). 2025 Mar 27. doi: 10.1007/s00261-025-04908-w. PMID: 40146310 

Bian X, Gu X. Risk factors for recurrence in patients with uterine fibroids treated with high-intensity focused ultrasound. Technol Health Care. 2025 Mar;33(2):945-950. doi: 10.1177/09287329241291362. Epub 2024 Nov 25. PMID: 39973853 

Peregrino PFM, Messina ML, Júnior JMS, Baracat EC. Magnetic resonance-guided focused ultrasound for uterine fibroids. Clinics (Sao Paulo). 2025 Mar 4;80:100603. doi: 10.1016/j.clinsp.2025.100603. eCollection 2025. PMID: 40043426 

Tonguc T, Savchenko O, Ramig O, Stader JM, Kießling F, Küppers J, Egger EK, Thudium M, Martin P, Poll W, Schild HH, Conrad R, Essler M, Mustea A, Strunk HM, Marinova M. Ablation of symptomatic uterine fibroids with the Mirabilis system for rapid noninvasive ultrasound-guided high-intensity focused ultrasound (HIFU): a prospective observational clinical study. Radiol Med. 2025 Mar 10. doi: 10.1007/s11547-025-01972-6. PMID: 40063166 

Yang M, Chen Y, Zhou X, Yu R, Huang N, Chen J. Machine learning models for prediction of NPVR ≥80% with HIFU ablation for uterine fibroids. Int J Hyperthermia. 2025 Dec;42(1):2473754. doi: 10.1080/02656736.2025.2473754. Epub 2025 Mar 23. PMID: 40122145 

Inbar Y, Rabinovici J, Sverdlove R, Ziv-Baran T, Machtinger R. Long-term outcomes and re-intervention rates in women undergoing mri-guided focused ultrasound (mrgfus) for uterine fibroids: a 7-year follow-up study. J Assist Reprod Genet. 2025 Feb 3. doi: 10.1007/s10815-025-03405-9. PMID: 39899259 

Huang X, Shen L, Liu Y, Li Q, Bai S, Wang F, Yang Q. Value of a combined magnetic resonance-enhanced and diffusion-weighted imaging dual-sequence radiomics model in predicting the efficacy of high-intensity focused ultrasound ablation for uterine fibroids. BMC Med Imaging. 2025 Feb 17;25(1):53. doi: 10.1186/s12880-025-01593-5. PMID: 39962435 

Chen S, Zhang D, Ding G, Chen M, Wu S, Zou J. Nomogram for predicting the efficacy of high-intensity focused ultrasound ablation for uterine fibroids based on oxytocin experimentation and ultrasonographic features: a retrospective single-center study. Int J Hyperthermia. 2025 Dec;42(1):2436602. doi: 10.1080/02656736.2024.2436602. Epub 2025 Jan 5. PMID: 39757002 

Wang J, Xie Y, Zeng C, Nie L, Yang Y. Predictive value of abnormal expression of MPHOSPH9 in reintervention after high intensity focused ultrasound treatment of uterine fibroids. J Obstet Gynaecol Res. 2025 Jan;51(1):e16205. doi: 10.1111/jog.16205. PMID: 39780408 

Hao Q, Liu J, Hou R, Huang W, Liao J, Lin Z, Zhang T. Conventional magnetic resonance imaging combined with three-dimensional ultrasound for preoperative prediction of immediate ablation rate in high-intensity focused ultrasound treatment of uterine fibroids. Int J Hyperthermia. 2025 Dec;42(1):2448545. doi: 10.1080/02656736.2024.2448545. Epub 2025 Jan 22. PMID: 39842805 

Shen L, Huang X, Liu Y, Bai S, Wang F, Yang Q. Multi-sequence magnetic resonance imaging radiomics combined with imaging features predicts the difficulty of HIFU treatment of uterine fibroids. Sci Rep. 2025 Jan 25;15(1):3259. doi: 10.1038/s41598-025-86958-0. PMID: 39863675 

Chen Y, Yi J, Lin S, Xie X, Liu X, Guo SW. Reproductive outcomes of high-intensity focused ultrasound ablation and myomectomy for uterine fibroids: a systematic review and meta-analysis. Reprod Biomed Online. 2025 Jan;50(1):104436. doi: 10.1016/j.rbmo.2024.104436. Epub 2024 Sep 3. PMID: 39616958 

Goudarzi S, Jones RM, Lee YHW, Hynynen K. Transducer module apodization to reduce bone heating during focused ultrasound uterine fibroid ablation with phased arrays: A numerical study. Med Phys. 2024 Dec;51(12):8670-8687. doi: 10.1002/mp.17427. Epub 2024 Sep 28. PMID: 39341358 

Wang L, Liu Y, Lin J, Deng J, Yang M, Lv F. Effect of “T2-rim sign” related parameters on high-intensity focused ultrasound ablation of uterine fibroids. Eur J Radiol. 2024 Dec;181:111767. doi: 10.1016/j.ejrad.2024.111767. Epub 2024 Sep 27. PMID: 39357287 

Hazimeh D, Coco A, Casubhoy I, Segars J, Singh B. The Annual Economic Burden of Uterine Fibroids in the United States (2010 Versus 2022): A Comparative Cost-Analysis. Reprod Sci. 2024 Dec;31(12):3743-3756. doi: 10.1007/s43032-024-01727-0. Epub 2024 Oct 25. PMID: 39455488 

Zhao M, Wang D, Zhang Y, Wang L. Evaluating pregnancy outcomes in women with uterine fibroids treated with high-intensity focused ultrasound: insights from a single-institution study. Reprod Health. 2024 Dec 18;21(1):184. doi: 10.1186/s12978-024-01930-x. PMID: 39696568 

Dominoni M, Gardella B, Gritti A, Pasquali MF, Spinillo A. Conservative Treatment Of Uterine Myomas: A Network Meta-analysis Of Randomized Controlled Studies.: NMA For Uterine Myomas Conservative Treatment. J Minim Invasive Gynecol. 2024 Dec 27:S1553-4650(24)01560-7. doi: 10.1016/j.jmig.2024.12.012. PMID: 39733851 

Liu Y, Jin W, Wang K, Chang Z, Zhang L. Traditional Chinese Medicine Nursing for Gastrointestinal Function Recovery in Patients with Uterine Fibroids After High-Intensity Focused Ultrasound Treatment. J Multidiscip Healthc. 2024 Dec 23;17:6099-6108. doi: 10.2147/JMDH.S496714. eCollection 2024. PMID: 39734795 

Bao YM, Ma WW, Li S, Jiang L, Yang MJ, Chen JY. The safety and efficacy of myomectomy in the treatment of recurrent uterine fibroids after HIFU. Int J Gynaecol Obstet. 2024 Dec;167(3):997-1003. doi: 10.1002/ijgo.15757. Epub 2024 Jun 27. PMID: 38935313 

Liu H, Zeng J, Jinyun C, Liu X, Deng Y, Li C, Li F. Robust Radiomics Models for Predicting HIFU Prognosis in Uterine Fibroids Using SHAP Explanations: A Multicenter Cohort Study. J Imaging Inform Med. 2024 Nov 11. doi: 10.1007/s10278-024-01318-0. PMID: 39528886 

Liu Y, Xiao Z, Luo Y, Qiu X, Wang L, Deng J, Yang M, Lv F. Predictive value of contrast-enhanced MRI for the regrowth of residual uterine fibroids after high-intensity focused ultrasound treatment. Insights Imaging. 2024 Nov 15;15(1):274. doi: 10.1186/s13244-024-01839-w. PMID: 39546185 

Dohmen S, Recker F, Ivanova Y, Strunk HM, Tonguc T, Ramig O, Thudium M, Stader JM, Conrad R, Essler M, Egger EK, Mustea A, Gortchev GA, Dimitrov D, Marinova M. Ultrasound-guided high-intensity focused ultrasound for symptomatic uterine fibroids: clinical outcome of two European centers. Eur Radiol. 2024 Nov 29. doi: 10.1007/s00330-024-11230-4. PMID: 39613955 

Knorren ER, Nijholt IM, Schutte JM, Boomsma MF. Magnetic Resonance-Guided Focused Ultrasound Surgery for Gynecologic Indications. Magn Reson Imaging Clin N Am. 2024 Nov;32(4):615-628. doi: 10.1016/j.mric.2024.02.005. Epub 2024 Mar 27. PMID: 39322351 

Zhang G, Li L, Sun M, Yu X. Progress in High Intensity Focused Ultrasound Ablation for Fertility Preservation Therapy of Uterine Fibroids and Adenomyosis. Reprod Sci. 2024 Nov 12. doi: 10.1007/s43032-024-01745-y. PMID: 39532767 

Fan C, Qian Y, Li Z, Li B. Ultrasound-guided microwave, radiofrequency, and high intensity focused ultrasound (HIFU) ablation in treating uterine leiomyoma: A systemic review and meta-analysis of retrospective studies. Biotechnol Genet Eng Rev. 2024 Nov;40(3):2429-2443. doi: 10.1080/02648725.2023.2199560. Epub 2023 Apr 10. PMID: 37036037 

Bitton RR, Ghanouni P. Reply to Letter to the Editor: “What predicts durable symptom relief of uterine fibroids treated with MRI-guided focused ultrasound? A multi-center trial in 8 academic centers”. Eur Radiol. 2024 Oct 18. doi: 10.1007/s00330-024-11104-9. PMID: 39422722 

Zhou Y, Huang Q, Chen P, Bai J, Ji X. Letter to the Editor: “What predicts durable symptom relief of uterine fibroids treated with MRI-guided focused ultrasound? A multicenter trial in 8 academic centers”. Eur Radiol. 2024 Oct 18. doi: 10.1007/s00330-024-11103-w. PMID: 39422724 

Hazimeh D, Coco A, Casubhoy I, Segars J, Singh B. The Annual Economic Burden of Uterine Fibroids in the United States (2010 Versus 2022): A Comparative Cost-Analysis. Reprod Sci. 2024 Oct 25. doi: 10.1007/s43032-024-01727-0. PMID: 39455488 

Chen Y, Liu M, Huang D, Liu Z, Yang A, Qin N, Shu J. Predicting Short-term and Long-term Efficacy of HIFU Treatment for Uterine Fibroids Based on Clinical Information and MRI: A Retrospective Study. Acad Radiol. 2024 Oct 30:S1076-6332(24)00683-4. doi: 10.1016/j.acra.2024.09.040. PMID: 39482211 

Knorren ER, Nijholt IM, Schutte JM, Boomsma MF. Magnetic Resonance-Guided Focused Ultrasound Surgery for Gynecologic Indications. Magn Reson Imaging Clin N Am. 2024 Nov;32(4):615-628. doi: 10.1016/j.mric.2024.02.005. Epub 2024 Mar 27. PMID: 39322351 

Wang T, Wen Y, Wang Z. nnU-Net based segmentation and 3D reconstruction of uterine fibroids with MRI images for HIFU surgery planning. BMC Med Imaging. 2024 Sep 6;24(1):233. doi: 10.1186/s12880-024-01385-3. PMID: 39243001 

Goudarzi S, Jones RM, Lee YHW, Hynynen K. Transducer module apodization to reduce bone heating during focused ultrasound uterine fibroid ablation with phased arrays: A numerical study. Med Phys. 2024 Sep 28. doi: 10.1002/mp.17427. PMID: 39341358 

Zhang Q, Liang X, Chen Z. An Updated Review of Thermal Ablation Technology for Uterine Fibroids and Adenomyosis: Focusing on Protecting Fertility. Int J Womens Health. 2024 Sep 23;16:1551-1563. doi: 10.2147/IJWH.S473005. eCollection 2024. PMID: 39346931 

Zhang P, Xie L, Chen J, Zhan P, Xing HR, Yuan Y. The Impact of HIFU Ablation on the Histopathological Features of Locally Recurrent Fibroids Tissue Post-HIFU Treatment. Ultrasound Med Biol. 2024 Sep;50(9):1381-1386. doi: 10.1016/j.ultrasmedbio.2024.05.014. Epub 2024 Jun 18. PMID: 38897842 

Gu W, Yuan J, Zhou Y, Li Y, Wang Y. Impact of ultrasound-guided high-intensity focused ultrasound for the treatment of uterine fibroids on ovarian reserve and quality of life: a single-center prospective cohort study. BMC Womens Health. 2024 Aug 24;24(1):470. doi: 10.1186/s12905-024-03315-5. PMID: 39182055 

Xue H, Wu S, Xiao K, Ding G, Chen S. Sonographic features of uterine fibroids that predict the ablation rate and efficacy of high-intensity focused ultrasound. Front Oncol. 2024 Aug 16;14:1451626. doi: 10.3389/fonc.2024.1451626. eCollection 2024. PMID: 39220651 

Ng VW, Cheung VY. Ultrasound-Guided High-Intensity Focused Ultrasound of Uterine Fibroids and Adenomyosis: An 11-Year Experience from a Single Center in Hong Kong. J Clin Med. 2024 Aug 14;13(16):4788. doi: 10.3390/jcm13164788. PMID: 39200930 

Wang L, Liu Y, Lin J, Pan Y, Liu Y, Lv F. The Predictive Effect of Quantitative Analysis of Signal Intensity Heterogeneity on T2-Weighted MR Images for High-intensity Focused Ultrasound Treatment of Uterine Fibroids. Acad Radiol. 2024 Jul;31(7):2848-2858. doi: 10.1016/j.acra.2024.04.023. Epub 2024 May 3. PMID: 38704283 

Tang NH, Fang CL, Hu WH, Tian L, Lin C, Hu HQ, Shi QL, Xu F. Response: Age-stratified risk factors of re-intervention for uterine fibroids treated with high-intensity focused ultrasound. Int J Gynaecol Obstet. 2024 Jul;166(1):462-463. doi: 10.1002/ijgo.15584. Epub 2024 May 9. PMID: 38721712 

Vannuccini S, Petraglia F, Carmona F, Calaf J, Chapron C. The modern management of uterine fibroids-related abnormal uterine bleeding. Fertil Steril. 2024 Jul;122(1):20-30. doi: 10.1016/j.fertnstert.2024.04.041. Epub 2024 May 8. PMID: 38723935 

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Chen Y, Zhao F, Feng L, Zhou F, Zhou X. Evaluating the Effects of Water Balloons on High-Intensity Focused Ultrasound for Treating Uterine Fibroids. Ultrasound Med Biol. 2024 Feb 14:S0301-5629(24)00027-9. doi: 10.1016/j.ultrasmedbio.2024.01.013. PMID: 38360493  

Cheng Y, Yang L, Wang Y, Kuang L, Pan X, Chen L, Cao X, Xu Y. Development and validation of a radiomics model based on T2-weighted imaging for predicting the efficacy of high intensity focused ultrasound ablation in uterine fibroids. Quant Imaging Med Surg. 2024 Feb 1;14(2):1803-1819. doi: 10.21037/qims-23-916. Epub 2024 Jan 22. PMID: 38415139  

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Park SA, Lee J, Kim HY. Virtual reality education program for women with uterine tumors treated by high-intensity focused ultrasound. Heliyon. 2023 Dec 16;10(1):e23759. doi: 10.1016/j.heliyon.2023.e23759. eCollection 2024 Jan 15. PMID: 38226233  

Liu Y, Lv F, Liu Y, Zhong Y, Qin Y, Lv F, Xiao Z. Factors influencing magnetic resonance imaging changes associated with pelvic bone injury after high-intensity focused ultrasound ablation of uterine fibroids: a retrospective case-control study. Quant Imaging Med Surg. 2024 Jan 3;14(1):179-193. doi: 10.21037/qims-23-323. Epub 2024 Jan 2. PMID: 38223045  

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