Focused Ultrasound Therapy
Focused ultrasound is an early-stage, non-invasive, therapeutic technology with the potential to improve the quality of life and decrease the cost of care for patients with multiple sclerosis (MS). This novel technology focuses beams of ultrasound energy precisely and accurately on targets deep in the brain without damaging surrounding normal tissue.
How it Works
Where the beams converge, focused ultrasound produces several therapeutic effects that are being evaluated. One is precise ablation (thermal destruction of tissue), which enables treatment without surgery. This treatment is only focused on the movement disorder, and is not intended to treat the underlying cause of MS.
The second mechanism utilizing focused ultrasound is to possibly treat the actual underlying cause of multiple sclerosis and preserve the myelin sheath (insulation around nerves) which allows nerves to transmit signals quickly and efficiently. Preclinical work has shown that focused ultrasound accelerates remyelinization of nerves.
The third area of research takes advantage of the ability of focused ultrasound to open the blood-brain barrier (BBB). Focused ultrasound can reversibly and safely allow the blood vessels in the brain to partially “open” the otherwise tight junctions, allowing certain therapies (genes, stem cells, neuroprotective and/or neurorestorative drugs, and medications) to enter the brain in specific areas. Current avenues of research involve delivering these therapies directly from the bloodstream itself or even within or attached to microbubbles.
For certain patients, focused ultrasound could provide a noninvasive alternative to surgery with less risk of complications – such as surgical wound healing or infection – at a lower cost. It also offer precision targeting to minimize damage to healthy tissue and opens BBB safely to enhance drug delivery and immune effects. Focused ultrasound can also be repeated, if necessary.
A clinical trial has begun in Canada treating patients with multiple sclerosis induced hand tremor with focused ultrasound. This trial is only open to citizens of Canada.
Regulatory Approval and Reimbursement
Focused ultrasound treatment for multiple sclerosis is not yet approved by regulatory bodies or covered by medical insurance companies.
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