- Last Updated: June 26, 2018
Focused Ultrasound Therapy
Focused ultrasound is an early-stage, noninvasive, therapeutic technology with the potential to improve the quality of life and decrease the cost of care for patients with osteoid osteoma. This novel technology focuses beams of ultrasound energy precisely and accurately on targets deep in the body without damaging surrounding normal tissue. Where the beams converge, the ultrasound produces precise ablation (thermal destruction of tissue) enabling osteoid osteoma to be treated without surgery.
The primary options for treatment of osteoid osteoma include pain medications, but some cases require invasive surgery.
For certain patients, focused ultrasound could provide a noninvasive alternative to surgery with less risk of complications and lower cost.
- Focused ultrasound is noninvasive, so it does not carry added concerns like surgical wound healing or infection.
- Focused ultrasound can reach the desired target without damaging surrounding tissue.
- It can be repeated, if necessary.
A study has opened at the University of California in San Francisco (UCSF) and Stanford University, which is comparing MR-guided focused ultrasound treatment for osteoid osteoma to radiofrequency ablation.
For more information or to enroll at UCSF, please contact Kenneth Gao at
To enroll at Stanford, contact Mariam Stephen at or 650-497-9749.
A recent study assessed MR-guided focused ultrasound to treat osteoid osteoma at The Hospital for Sick Children (SickKids) in Toronto, Canada. The first patient was treated in July and experienced a significant reduction in his pain, according to a press release from SickKids. Publication of the results is expected soon. A registry, funded in part by the Foundation, has begun and will enroll more patients at additional sites worldwide. For more information, contact Maria Lamberti-Pasculli, RN, at 416-813-6456 or .
A clinical trial for patients with clinical and imaging diagnosis of non-spinal osteoid osteoma is currently being conducted at the Sapienza University of Rome. For further information, contact: Alessandro Napoli, MD, PhD at or +390649974540
There is a trial ongoing at Children's National Medical Center in Washington, DC. For more information, contact Amanda Mahoney, MA at 202-476-2263 or .
For a full list of osteoid osteoma clinical trials, please see here.
Regulatory Approval and Reimbursement
The ExAblate focused ultrasound system manufactured by Insightec is approved in Europe for the treatment of osteoid osteoma.
To date, focused ultrasound is not universally reimbursed by medical insurers for treatment of osteoid osteoma.
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Masciocchi C, Zugaro L, Arrigoni F, Gravina GL, Mariani S, La Marra A, Zoccali C, Flamini S, Barile A. Radiofrequency ablation versus magnetic resonance guided focused ultrasound surgery for minimally invasive treatment of osteoid osteoma: a propensity score matching study. Eur Radiol. 2015 Nov 26.
Click here for additional references from PubMed.