Focused Ultrasound Therapy

Outside Approval Square

Focused ultrasound is an early-stage, noninvasive, therapeutic technology with the potential to improve the quality of life and decrease the cost of care for patients with bone tumors. This novel technology focuses beams of ultrasound energy precisely and accurately on targets deep in the body without damaging surrounding normal tissue. Where the beams converge, the ultrasound produces precise ablation (thermal destruction of tissue) enabling bone tumors to be treated without surgery. Note: there are some specific bone tumors that have their own entry into our website. For osteoid osteoma, multiple myeloma, sacral chordoma, and bone metastases, please see those separate listings.

The primary options for treatment of bone tumors include invasive surgery.

For certain patients, focused ultrasound could provide a noninvasive alternative to surgery with less risk of complications and lower cost.

Clinical Trials SquareAdvantages:

  • Focused ultrasound is noninvasive, so it does not carry added concerns like surgical wound healing or infection.
  • Focused ultrasound can reach the desired target without damaging surrounding tissue.
  • It can be repeated, if necessary.

Clinical Trials

There is a multi-site clinical trial comparing the treatment of osteoid osteoma with magnetic resonance guided focused ultrasound vs. radiofrequency ablation. 

There is a phase IV, post approval clinical trial at many centers in the US that is looking at the pain palliation when magnetic resonance guided focused ultrasound is used to treat bone metastasis. 

There is a pediatric and young adult study underway in Washington, DC that involves the use of FUS in combination with a thermally sensitive form of liposomal doxorubicin on a variety of solid tumors.

There is a multi-center pediatric and young adult trial using focused ultrasound to ablate tumors located near bone.

The clinical trial in Taipei, comparing magnetic resonance guided focused ultrasound and external beam radiation for the treatment for bone metastasis has been completed. 

There is a clinical trial in Surrey, United Kingdom assessing pain palliation when magnetic resonance guided focused ultrasound is used for treatment of bone metastasis. 

See a full list of bone tumor clinical trials > 

See a list of treatment sites >
See a list of clinical trials sites >
See a list of laboratory research sites >

Regulatory Approval and Reimbursement

Bone tumor treatment is approved in Europe, Russia, and China. It is not approved in the United States.

Notable Papers

Arrigoni F, Bruno F, Palumbo P, Zugaro L, Zoccali C, Barile A, Masciocchi C. Magnetic resonance-guided focused ultrasound surgery treatment of non-spinal intra-articular osteoblastoma: feasibility, safety, and outcomes in a single-center retrospective analysis. Int J Hyperthermia. 2019;36(1):768-775. doi: 10.1080/02656736.2019.1639833.

Bitton RR, Webb TD, Pauly KB, Ghanouni P. Prolonged Heating in Nontargeted Tissue During MR-guided Focused Ultrasound of Bone Tumors. J Magn Reson Imaging. 2019 Apr 5. doi: 10.1002/jmri.26726. 

Menikou G, Yiallouras C, Yiannakou M, Damianou C. MRI-guided focused ultrasound robotic system for the treatment of bone cancer. Int J Med Robot. 2016 Jul 15. doi: 10.1002/rcs.1753.

Chen W, Zhu H, Zhang L, Li K, Su H, Jin C, Zhou K, Bai J, Wu F, Wang Z. Primary bone malignancy: effective treatment with high-intensity focused ultrasound ablation. Radiology. 2010 Jun;255(3):967-78. doi: 10.1148/radiol.10090374.

Click here for additional references from PubMed.

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