Focused Ultrasound Therapy
Focused ultrasound is an early-stage, noninvasive, therapeutic technology with the potential to improve the quality of life and decrease the cost of care for patients with dystonia. This novel technology focuses beams of ultrasound energy precisely and accurately on targets deep in the brain without damaging surrounding normal tissue.
How it Works
Where the beams converge, focused ultrasound produces precise ablation (thermal destruction of tissue) enabling dystonia to be treated without surgery. While there are several potential treatment targets, the ventrooralis (Vo nucleus of the thalamus) has been the target of initial studies treating musician’s or writer’s dystonia.
The primary options for treatment of dystonia include medications and invasive surgery. However, medications work temporarily, whereas focused ultrasound will offer a more durable treatment that may be permanent.
For certain patients, focused ultrasound could provide a noninvasive alternative to surgery with less risk of complications – such as surgical wound healing or infection – at a lower cost. If needed, focused ultrasound can also be repeated.
A clinical trial in Japan has begun treating patients with cervical dystonia, which has a disease of the muscles of the neck resulting in torticollis (twisting of the neck). For more information on being a part of this study, the principal investigator has shared his email address: Shiro Horisawa, MD 堀澤士朗 ..
Another clinical trial at Toronto Western Hospital is based on a variety of causes of movement disorders and includes dystonia in the spectrum of diseases for treatment. The purpose is to examine the safety and initial effectiveness of focused ultrasound for treatment of movement disorders. This study is ONLY open to citizens of Canada.
Regulatory Approval and Reimbursement
Focused ultrasound treatment for dystonia is not yet approved by regulatory bodies or covered by medical insurance companies.
Horisawa S, Yamaguchi T, Abe K, Hori H, Fukui A, Iijima M, Sumi M, Hodotsuka K, Konishi Y, Kawamata T, Taira T. Magnetic Resonance-Guided Focused Ultrasound Thalamotomy for Focal Hand Dystonia: A Pilot Study. Mov Disord. 2021 May 29. doi: 10.1002/mds.28613.
Gallay MN, Moser D, Magara AE, Haufler F, Jeanmonod D. Bilateral MR-Guided Focused Ultrasound Pallidothalamic Tractotomy for Parkinson's Disease With 1-Year Follow-Up. Front Neurol. 2021 Feb 9;12:601153. doi: 10.3389/fneur.2021.601153. eCollection 2021.
Martino D, Rockel CP, Bruno V, Mazerolle EL, Jetha S, Pichardo S, Pike GB, Kiss ZHT. Dystonia following thalamic neurosurgery: A single centre experience with MR-guided focused ultrasound thalamotomy. Parkinsonism Relat Disord. 2020 Feb;71:1-3. doi: 10.1016/j.parkreldis.2019.11.019. Epub 2019 Nov 26.
Horisawa S, Fukui A, Tanaka Y, Wendong L, Yamahata H, Kawamata T, Taira T. Pallidothalamic Tractotomy (Forel’s Field H1-tomy) for Dystonia: preliminary Results. World Neurosurg. 2019 Sep;129:e851-e856. doi:10.1016/j.wneu.2019.06.055. Epub 2019 Jun 14.
Horisawa S, Oka M, Kohara K. Kawamata T, Taira T. Staged bilateral pallidotomy for dystonic camptocormia: case report. J Neurosurg. 2018 Oct 19;131(3):839-842. doi: 10.3171/2018.5.JNS1840.
Horisawa S, Yamaguchi T, Abe K, Hori H, Sumi M, Konishi Y, Taira T. A single case of MRI-guided focused ultrasound ventro-oral thalamotomy for musician's dystonia. J Neurosurg. 2018 Sep 21:1-3. doi: 10.3171/2018.5.JNS173125.
Krishna V, Sammartino F, Rezai A. A Review of the Current Therapies, Challenges, and Future Directions of Transcranial Focused Ultrasound Technology: Advances in Diagnosis and Treatment. JAMA Neurol. 2018 Feb 1;75(2):246-254. doi: 10.1001/jamaneurol.2017.3129.
Krack P, Martinez-Fernandez R, Del Alamo M, Obeso JA. Current applications and limitations of surgical treatments for movement disorders. Mov Disord. 2017 Jan;32(1):36-52. doi: 10.1002/mds.26890. Review.
Horisawa S, Taira T, Goto S, Ochiai T, Nakajima T. Long-term improvement of musician’s dystonia after stereotactic ventro-oral thalamotomy. Ann Neurol 2013;74:648-654.
Taira T, Hori T. Stereotactic ventrooralis thalamotomy for task-specific focal hand dystonia (writer’s cramp). Stereotact Funct Neurosurg 2003;80:88–91.
Taira T, Harashima S, Hori T. Neurosurgical treatment for writer’s cramp. Acta Neurochir 2003;[Suppl]87:129-131.
Goto S, Tsuiki H, Soyama N, et al. Stereotactic selective Vo-complex thalamotomy in a patient with dystonic writer’s cramp. Neurology 1997;49:1173–1174.
Click here for additional references on PubMed.