Focused Ultrasound Therapy

Outside Approval Square

Focused ultrasound is an early-stage, noninvasive, therapeutic technology with the potential to improve the quality of life and decrease the cost of care for patients with glaucoma. This novel technology focuses beams of ultrasound energy precisely and accurately on targets in the eye without damaging surrounding normal tissue. Where the beams converge, the ultrasound produces precise ablation (thermal destruction of tissue) that re-opens the mesh-like supporting channel of the eye were the fluid would normally drain. This enables glaucoma to be treated without surgery.

The primary options for treatment of glaucoma includes medication or surgery.

For certain patients, focused ultrasound could provide a more permanent solution to medications or a noninvasive alternative to surgery with less risk of complications and lower cost.

Clinical Trials Square


  • Focused ultrasound is noninvasive, so it does not carry added concerns like surgical wound healing or infection.
  • Focused ultrasound can reach the desired target without damaging surrounding tissue.
  • It can be repeated, if necessary.

Clinical Trials

There are currently no focused ultrasound clinical trials recruiting patients with glaucoma. 

See a list of treatment sites >
See a list of clinical trials sites >
See a list of laboratory research sites >

Regulatory Approval and Reimbursement 

The EyeTechCare device has CE approval in Europe and CFDA approval in China.

Notable Papers

Hugo J, Matonti F, Beylerian M, Zanin E, Aptel F, Denis D. Safety and efficacy of high-intensity focused ultrasound in severe or refractory glaucoma. Eur J Ophthalmol. 2019 Sep 25:1120672119874594. doi: 10.1177/1120672119874594.

Rivero-Santana A, Pérez-Silguero D, Pérez-Silguero MA, Encinas-Pisa P. Pupil Ovalization and Accommodation Loss after High-intensity Focused Ultrasound Treatment for Glaucoma: A Case Report. J Curr Glaucoma Pract. 2019 May-Aug;13(2):77-78. doi: 10.5005/jp-journals-10078-1256.

Sousa DC, Ferreira NP, Marques-Neves C, Somers A, Vandewalle E, Stalmans I, Pinto LA. High-intensity Focused Ultrasound Cycloplasty: Analysis of Pupil Dynamics. J Curr Glaucoma Pract. 2018 Sep-Dec;12(3):102-106. doi: 10.5005/jp-journals-10028-1253.

Graber M, Rothschild PR, Khoueir Z, Bluwol E, Benhatchi N, Lachkar Y. High intensity focused ultrasound cyclodestruction versus cyclodiode treatment of refractory glaucoma: A retrospective comparative study. J Fr Ophtalmol. 2018 Sep;41(7):611-618. doi: 10.1016/j.jfo.2018.02.005. Epub 2018 Aug 20.

Giannaccare G, Vagge A, Sebastiani S, Urbini LE, Corazza P, Pellegrini M, Carmassi L, Bergamini F, Traverso CE, Campos EC. Ultrasound Cyclo-Plasty in Patients with Glaucoma: 1-Year Results from a Multicentre Prospective Study. Ophthalmic Res. 2018 May 16:1-6. doi: 10.1159/000487953.

Deb-Joardar N, Reddy KP. Application of high intensity focused ultrasound for treatment of open-angle glaucoma in Indian patients. Indian J Ophthalmol. 2018 Apr;66(4):517-523. doi: 10.4103/ijo.IJO_1024_17.

De Gregorio A, Pedrotti E, Stevan G, Montali M, Morselli S. Safety and efficacy of multiple cyclocoagulation of ciliary bodies by high-intensity focused ultrasound in patients with glaucoma. Graefes Arch Clin Exp Ophthalmol. 2017 Oct 17. doi: 10.1007/s00417-017-3817-4.

Graber M, Khoueir Z, Beauchet A, Benhatchi N, Hammoud S, Lachkar Y. High intensity focused ultrasound as first line treatment in patients with chronic angle closure glaucoma at risk for malignant glaucoma. J Fr Ophtalmol. 2017 Apr;40(4):264-269. doi: 10.1016/j.jfo.2016.10.013.

Mastropasqua R, Fasanella V, Mastropasqua A, Ciancaglini M, Agnifili L. High-Intensity Focused Ultrasound Circular Cyclocoagulation in Glaucoma: A Step Forward for Cyclodestruction? J Ophthalmol. 2017;2017:7136275. doi: 10.1155/2017/7136275. Epub 2017 Apr 22.

Graber M, Khoueir Z, Beauchet A, Benhatchi N, Hammoud S, Lachkar Y. High intensity focused ultrasound as first line treatment in patients with chronic angle closure glaucoma at risk for malignant glaucoma. J Fr Ophtalmol. 2017 Mar 22. pii: S0181-5512(17)30073-6. doi: 10.1016/j.jfo.2016.10.013.

Click here for additional references from PubMed.

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