Blog

Jill O'Donnell-Tormey: The Promise of Cancer Immunotherapy and Focused Ultrasound

Jill O'Donnell-Tormey, PhD, is chief executive officer and director of scientific affairs at the Cancer Research Institute. In 2017, CRI and the Focused Ultrasound Foundation partnered with the goal of advancing the development of new focused ultrasound and cancer immunotherapy treatments. A major part of the partnership is a joint fund that supports research to move toward new combination therapies. That fund awarded its first research grant in June of 2018. Dr. O’Donnell-Tormey appeared at the 6th International Symposium on Focused Ultrasound in October to discuss the partnership. Below is an edited transcript of our interview with her.

Why did you partner with Focused Ultrasound Foundation?
As immunotherapy was starting to gather momentum and there were more FDA approvals of immunotherapy, the Focused Ultrasound Foundation thought there might be a place to combine immunotherapy and focused ultrasound. So that was the impetus.

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Pancreatic Cancer: Tumor Ablation Using Focused Ultrasound and the Challenges of Immunotherapy

Joo Ha Hwang, MD, PhD, is Professor of Medicine, Gastroenterology and Hepatology at Stanford University. He is also president of the International Society for Therapeutic Ultrasound, a partner organization of the Focused Ultrasound Foundation. Dr. Hwang became interested in focused ultrasound through his work with pancreatic cancer patients: He wanted to find a therapy that would prolong their lives or even cure them. Today he is more optimistic than ever about the possibility of using focused ultrasound to treat pancreatic cancer. Below is an edited transcript of our conversation with him.

Why are you so enthusiastic about this technology?
I've been in this field since 2000, so I've been actively doing focused ultrasound research for 18 years. Much of that research has been looking at enhancing drug delivery for pancreatic cancer using focused ultrasound. We have achieved great results, but the problem has been that there are no real effective chemotherapeutic agents. Even our best agents have very modest efficacy.

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Collaboration: Commercialization in the Evolving Focused Ultrasound Landscape

Across the medical device industry there is a very strong startup scene, and the field of focused ultrasound is no exception. According to our 2018 State of the Field Report, there are 70+ companies in the field globally; 42 of those companies are actively developing a device (or devices), with the remainder supporting other aspects of the field (OEM suppliers, distributers, etc.). The field comprises a vibrant community of innovators who are developing novel ways to solve important health problems using ultrasound technology as a therapeutic alternative to the standard of care.

Startup companies in the medical device space historically have excelled at the innovation and engineering portion of the product development process. However, they have not often been expected to go through the entire product development process. That paradigm is changing now, and again, this is true for the focused ultrasound startup community. The intricacies of getting a device through regulatory approvals and determining how to successfully commercialize it can be difficult. The challenges can be particularly difficult for novel products like focused ultrasound devices, where there is no established path for the regulatory authorities, let alone marketers.

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Scott Whitaker: Transforming Healthcare and Medical Technology in the Digital Age

Scott Whitaker is President and CEO of AdvaMed, the world’s largest medical technology association. AdvaMed members make the medical devices, diagnostic products, and health information systems that are transforming healthcare through earlier disease detection, less invasive procedures, and more effective treatments. Whitaker will deliver a keynote address on Oct. 24 at the Focused Ultrasound Foundation’s 6th International Symposium. The following is a conversation we had with him in advance of the Symposium.

What excites you about focused ultrasound?
There are so many new and emerging medical technologies, and focused ultrasound is one of them. The noninvasive therapeutic technologies and the benefits that come with them will transform patient care in tremendous ways.

Prostate disease, pain associated with cancer metastases to bones, essential tremor – focused ultrasound hits on so many different diseases. To be able to avoid the need for drugs in dealing with some of these conditions through use of noninvasive therapies … I think we’ve only touched the surface of what’s to come.

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Gary Shapiro: The Importance of Innovation at the Intersection of Technology, Business, and Healthcare

Gary Shapiro is president and CEO of the Consumer Technology Association (CTA), which owns and produces CES, the global stage for innovation. In January 2018, Shapiro interviewed Dr. Kassell and John Grisham from the CES stage about focused ultrasound.

On Oct. 23, Shapiro will deliver a keynote speech on the importance of innovation at the intersection of technology, business, and healthcare at the 6th International Symposium on Focused Ultrasound. The following is a conversation we had with Shapiro about what excites him about focused ultrasound, how it fits into the landscape of technology disruption, and what he sees ahead in medical and healthcare innovation.

What excites you most about focused ultrasound technology?
Focused ultrasound is as significant as anything I have ever seen in my lifetime in terms of changing human pain and suffering and healing people. This is technology for good. This is an innovation solving major problems in the world.

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