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Fellowships and Research Funding Opportunities

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Many organizations and professional societies in healthcare offer fellowships and research funding in fields that overlap with current areas of interest within the focused ultrasound community. By sharing these opportunities, the Foundation aims to further focused ultrasound research in a wide array of specialties and for a variety of disorders. Hirshberg Foundation for Pancreatic Cancer Research Submission Deadline: August 15, 2023 Seed Grant Program ($75,000 for a single investigator award and $100,000 for a two-investigator collaborative award)The Foundation Seed Grant program has been extremely successful in providing research support to basic and clinical scientists and investigators in the United States and overseas. The Seed Grant program funds research in the following areas: treatment/therapy, patient care, early diagnosis, detection, cancer biology, basic science, prevention/metabolism and research core facilities. The goals of the program are: to provide start-up funding for basic scientists and clinicians who intent to test innovative ideas for improving diagnosis and to develop new treatment modalities for pancreatic cancer, to obtain preliminary data required for additional funding from other agencies for pancreatic cancer research, to impact on the understanding of pancreatic cancer cell biology, biochemistry, physiology, morphology, and response to therapy, to establish collaborations within the field for mutual projects that can be considered for further funding. Brain Tumour Foundation of Canada Submission Deadline: August 18, 2023 Research Grant ($25,000)Grants of up to $25,000 will be available for research taking place within Canada for any type of primary or metastatic brain tumour, adult or pediatric. Cancer Research Institute (CRI) Submission Deadline: September 1, 2023 Postdoctoral FellowshipThe CRI Irvington Postdoctoral Fellowship Program supports qualified young scientists at leading universities and research centers around the world who wish to receive training in fundamental immunology or cancer immunology. CRI seeks hypothesis-driven, mechanistic studies in both immunology and tumor immunology. The applicant and sponsor should make every effort to demonstrate the potential of the proposed studies to directly impact our understanding of the immune system’s role in cancer. Postdoctoral Fellowship to Promote Racial DiversityThe CRI Irvington Postdoctoral Fellowship to Promote Racial Diversity supports qualified young scientists from underrepresented minorities at leading universities and research centers around the world who wish to receive training in fundamental immunology and cancer immunology. Fellows train under the guidance of a world-renowned immunologist, who sponsors the fellow and prepares him or her for a productive and successful career in cancer immunology. The program will provide additional support for mentoring and career advancement to these individuals, as we work to build a more racially diverse and inclusive community of scientists working in immuno-oncology. American Academy of Neurology Submission Deadline: September 1, 2023 Practice Research Training Scholarship ($65,000 per year for two years )The American Academy of Neurology is pleased to offer a two-year award to support practice-based research, which is defined as “clinical research that evaluates translation of evidence into best clinical practice.” This may include evaluation of health services, quality of care, implementation of therapies, physician performance, or patient adherence. It is intended to create unique training opportunities previously difficult to access for neurologists. This award aims to recognize the importance of good practice-based research or comparative effectiveness research (CER) and encourage young investigators to use studies to improve health systems and services. The AAN Research Program demonstrates the AAN Board of Directors’ dedication to promoting neurology and neuroscience research and training. American Heart Association (AHA) Submission Deadline: September 7, 2023 AHA Postdoctoral FellowshipThe AHA Postdoctoral Fellowship is intended to enhance the training of postdoctoral applicants who are not yet independent. The applicant must be embedded in an appropriate investigative group with the mentorship, support, and relevant scientific guidance of a research mentor. Recognizing the unique challenges that clinicians, in particular, experience in balancing research and clinical activity, this award mechanism aims to be as flexible as possible to enable applicants to develop academic careers in research alongside fulfilling clinical service commitments. ChadTough Defeat DIPG Foundation Submission Deadline: September 15, 2023 Fellowship Grant ($300,000 over three years for post-doctoral fellows; $200,000 over 3 years for pre-doctoral fellows)The Fellowship Grant is awarded to outstanding pre-doctoral and post-doctoral fellows under the guidance of a mentor to help develop the next generation of leaders in DIPG research. Grant Opens: August 1, 2023Submission Deadline: February 8, 2024 New Investigator Grant ($400,000 over three years)The New Investigator Grant supports newly independent DIPG researchers working to establish DIPG research labs or established researchers (who have not previously conducted brain tumor research) to encourage them to start DIPG research. Game Changer Grant ($600,000 over three years)The Game Changer Grant funds hypothesis-driven research projects that represent an innovative approach to a major challenge in DIPG research, with a potential to lead to groundbreaking discoveries in the field. Share your funding opportunity! If you would like to include your organization’s funding opportunity on this list, please contact Emily Whipple, PhD, the Foundation’s Strategic Initiatives Director.
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Novel Breast Cancer Treatment Approaches Using Therapeutic Ultrasound, Immunotherapy, and Chemotherapy

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Key Points A new article provides an overview of the global state of the field for using focused ultrasound to treat breast cancer. The authors outlined ongoing research using several mechanisms of action and five devices and highlighted the technology’s ability to engage the immune system. Focused ultrasound has the potential to become an alternative or complement to existing treatments in the management of breast cancer. Combination of Focused Ultrasound, Immunotherapy, and Chemotherapy: New Perspectives in Breast Cancer Therapy A recently published article provides an overview of the worldwide state of the field for using focused ultrasound to treat breast cancer and breast cancer metastases. Researchers from LabTAU (a Focused Ultrasound Center of Excellence) and the Focused Ultrasound Foundation outlined ongoing research using several different focused ultrasound mechanisms of action and five devices. Data from the review, as collected through July 2022, included the following findings: There are nine ongoing clinical trials using focused ultrasound to treat various types and stages of breast cancer. Seven preclinical and three clinical studies have investigated the use of focused ultrasound for immunomodulation of breast cancers.  The focused ultrasound devices that are currently being used to treat breast cancer are made by Chongqing HAIFU, Theraclion, Profound Medical, the University of Utah (MUSE), and Insightec. Chongqing HAIFU’s Model-JC breast cancer device is being used for thermal ablation. Theraclion’s Echopulse device is being used to ablate breast tumors before the delivery of a cancer immunotherapy and chemotherapy. Profound’s Sonalleve device is providing thermal ablation before breast cancer surgery in one study and combining focused ultrasound with chemotherapy in another. The University of Utah’s MUSE focused ultrasound ablation device is being tested for the treatment of breast tumors with thermal ablation. The Insightec focused ultrasound device uses focused ultrasound to activate microbubbles and open the blood-brain barrier to deliver chemotherapy to breast cancer brain metastases as well as activate microbubbles for radiation sensitization. Sonopermeation is another mode of action of therapeutic ultrasound. It relies on the ultrasound activation of microbubbles to enhance the delivery of chemotherapy, and it can be performed using a clinically approved ultrasound imaging device. Focused ultrasound has already been approved in some European and Asian countries for the treatment of breast cancer using thermal ablation. Another condition, benign breast tumors, has been approved to be treated with focused ultrasound in Taiwan, Korea, Singapore, Hong Kong, and Europe. Focused ultrasound has the potential to become an alternative or complement to existing treatments in the management of breast cancer, with ongoing research evaluating the potential to improve treatment outcomes and decrease side effects. The technology may help address the need to develop noninvasive, personalized, and effective breast cancer treatments that have fewer side effects. Although many advances have been made in its treatment, breast cancer is still the most prevalent cancer in the world according to the World Health Organization. See Journal of Ultrasound in Medicine
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Focused Ultrasound Improves Liquid Biopsy Results in an Alzheimer’s Disease Model

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Key Points Dr. Hong Chen’s research team has completed a preclinical study using sonobiopsy (liquid biopsy) to improve the quantity of biomarkers released in a model of Alzheimer’s disease. The method significantly increased two biomarker levels when compared with conventional methods. Sonobiopsy could help diagnose Alzheimer’s disease and other neurodegenerative disorders. Focused Ultrasound–Mediated Liquid Biopsy in a Tauopathy Mouse Model Hong Chen, PhD, her co-senior author Arash Nazeri, MD, an assistant professor of radiology at the School of Medicine’s Mallinckrodt Institute of Radiology, and their research team at Washington University in St. Louis (WUSTL), recently completed a preclinical study using focused ultrasound–mediated liquid biopsy (sonobiopsy) to improve the quantity of biomarkers released from specific regions of the brain into the blood in a model of Alzheimer’s disease. The blood-brain barrier (BBB) limits the flow of biomarkers from the brain into the blood. Using focused ultrasound to open the BBB may allow the biomarkers to enter the bloodstream to be detected and measured. If scientists can capture these biomarkers, they may be able to identify the molecular drivers and pathways of Alzheimer’s disease and other diseases caused by neurodegeneration. According to WUSTL’s press release, this research is, “the first to open the door for noninvasive and targeted diagnosis and monitoring of neurodegenerative disorders with focused ultrasound–mediated liquid biopsy.” In the study, Dr. Chen’s group first sonicated the cerebral hemisphere to collect general data and compare it with standard blood-based liquid biopsy levels. This method significantly increased two different biomarker levels when compared with conventional methods (p-tau-181–to–mouse tau [m-tau] ratio: 1.7-fold increase, P = .006; p-tau-231–to–m-tau ratio: 1.4-fold increase, P = .048). The team then specifically sonicated the cerebral cortex and hippocampus to collect targeted sonobiopsy data. These spatially targeted applications further increased the biomarker levels by 2.3-fold (P < .001). The application also appeared to be safe, because after the researchers optimized the sonobiopsy parameters, they found no cellular differences in the effect of the ultrasound on the brain when compared with the other side. “We use the term ‘sonobiopsy’ as a shorthand for focused ultrasound–enhanced blood-based liquid biopsy,” explains Dr. Chen. “Our work has shown that sonobiopsy is a feasible method for releasing Alzheimer’s biomarkers into circulation. If it is translatable to humans, it could help diagnose Alzheimer’s disease and other tau-based neurodegenerative disorders.” Future questions to answer include learning the qualitative effects of sonobiopsy on plasma biomarker levels, characterizing the effects of each focused ultrasound parameter, determining the optimal blood collection time, and studying whether sonobiopsy can be used to release larger brain-derived protein biomarkers. “Focused ultrasound provides a unique opportunity to create a window into the brain to study various diseases noninvasively,” said the Foundation’s Director of Clinical Relationships, Suzanne LeBlang, MD. “The ability to increase the quantity and perhaps also the quality of analytes in the peripheral blood may make it possible to detect neurodegenerative disorders such as Alzheimer’s disease earlier, or even differentiate diseases such as a large multiple sclerosis plaque from a brain tumor. The hope is that not only can focused ultrasound–enhanced liquid biopsy aide in the diagnosis of diseases, but, based on the detailed analyses of samples, allow for more precision-based medicine and give each patient the medicine specific for their individual type and stage of disease – almost like antibiotic sensitivity testing.” See Radiology See the WUSTL Press Release See Sonobiopsy for Neurodegenerative Diseases: At the Intersection of Diagnostic and Therapeutic US, an associated editorial from J. Brian Fowlkes, PhD, at the University of Michigan. Media coverage of this study has been shared by Medgadget, Science Daily, News-Medical.net, and India Education Diary.
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HistoSonics to Begin Clinical Trial for Kidney Tumors

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Key Points HistoSonics has received FDA approval to begin a #HOPE4KIDNEY clinical trial in the US to treat primary renal tumors. The company’s Edison platform uses histotripsy to noninvasively and mechanically destroy tissue. This new trial comes on the heels of the #HOPE4LIVER studies, which have completed enrollment. The US Food and Drug Administration (FDA) has approved HistoSonics to begin a kidney tumor clinical trial in the US. The study will be called #HOPE4KIDNEY. The clinical trial will evaluate the safety and efficacy of HistoSonics’ Edison platform – a sonic beam therapy platform using histotripsy – to target and destroy primary renal tumors. Participant enrollment for the clinical trial is expected to begin in the second half of 2023 at up to 15 sites in the US. This trial comes after the company submitted results of their #HOPE4LIVER trials, which were conducted in the US and Europe. The initial analyses indicate the studies met both primary endpoints of safety and efficacy in destroying targeted liver tumors using histotripsy. “We are excited to expand on our experiences in successfully targeting and treating in the liver using our enhanced Edison platform that combines advanced imaging and targeting capabilities with real-time treatment monitoring,” said Mike Blue, president and CEO of HistoSonics, in a press release. “The kidney is a logical next application, as treating in the kidney has very similar procedural and anatomical considerations as the liver, and Edison was specifically designed to treat anywhere in the abdomen, as a starting point.” The Edison platform was granted Breakthrough Device Designation by the FDA in October 2021. The Breakthrough Devices Program was established to allow fast-tracking of novel devices that provide for more effective treatment or diagnosis of life-threatening or irreversibly debilitating diseases or conditions. Read HistoSonics’ Press Release >
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Neuroimaging and Fluid Biomarker Data from Sunnybrook’s Ongoing Alzheimer’s Study Published Focused Ultrasound for Motor Neuron Modulation of the Spinal Cord Blog: Gene Therapy and Rare Disease Focused Ultrasound Foundation and The Michael J. Fox Foundation for Parkinson’s Research Partner on Liquid Biopsy Clinical Trial Focused Ultrasound Treatment Comparable to Radiation Therapy for Patients with Painful Bone Metastases