Key Points
- The 184th Meeting of the Acoustical Society of America (ASA) took place in Chicago from May 8–12.
- The program included five sessions centered on focused ultrasound–related topics, and a record number of 61 abstracts pertained to the field.
- The Foundation thanks Frank Wolfram, PhD, for assistance with writing this meeting report.
The 184th Meeting of the Acoustical Society of America (ASA) took place in Chicago from May 8–12, 2023. ASA hold meetings twice a year: One in Chicago in the spring and the other interleaved in North America. There were more than 120 specialized sessions organized during the five days of the Chicago meeting. The content covered almost 50 different fields of acoustics, ranging from music and architectural sound to battlefield acoustics. However, dominantly and with increasing number, sessions were related to acoustic signal processing and biomedical ultrasound. Global experts share their research and have the chance to network through the meeting. ASA meetings are held in person, but individual remote presenting is also feasible.
Focused Ultrasound Sessions
The program included five sessions centered on focused ultrasound–related topics. Of particular interest were two sessions about therapeutic ultrasound technology development and applications (See 2aBAb: New Technology Developments for use in Focused Ultrasound Therapy I and II, chaired by Lawrence A. Crum, PhD, from the University of Washington) as well as a session about ultrasound for ocular therapy.
Prizes
Vera A. Khokhlova, PhD, received the Helmholtz-Rayleigh Interdisciplinary Silver Medal in Biomedical Acoustics and Physical Acoustics for contributions to the application of nonlinear acoustics to medical ultrasound.
Abstracts
To access the text for each of the 61 abstracts listed below, go to the web planner for the meeting and search by the abstract number below or by your own key words. Results are returned for each day of the conference, so click across the days to reveal results. The abstracts below are listed by indication or biomechanism.
Brain Overview
2aBAa7. Focused ultrasound in the human brain: Current and emerging applications by Nir Lipsman from the University of Toronto
Brain Blood-Brain Barrier (BBB) Opening
1aBAb9. Ultrasounds trigger reversible permeability of the cerebrovascular endothelium in a novel 3D-bioprinted model of the human blood-brain barrier by Mona Mirheydari from the University of Cincinnati
1aBAb12. Mechanistic study of blood-brain barrier opening by microbubbles and focused ultrasound by LuNa Hu from the University of Oxford
2aBAa1. Neuronavigated focused ultrasound for clinical BBB opening in Alzheimer’s and brain cancer patients by Elisa Konofagou from Columbia University
2aBAa3. Understanding the mechanisms of ultrasound-targeted, microbubble cavitation-mediated blood brain barrier opening by Grace Conway from the University of Pittsburgh
2pBAb11. Shaveless focused-ultrasound-induced blood-brain barrier opening in mice by Lu Xu from Washington University in St. Louis
4pBAb2. Real-time transcranial mapping in non-human primates and human subjects during opening of the blood-brain barrier by Elisa Konofagou from Columbia University
4pBAb3. Transcranial cavitation mapping of blood–brain barrier opening regions in Alzheimer’s disease patients using a neuronavigation-guided focused ultrasound system by Sua Bae from Columbia University
Brain Liquid Biopsy
2pBAb3. Sonobiopsy for expanding the application of therapeutic ultrasound in the diagnosis of brain diseases by Hong Chen from Washington University in St. Louis
Brain Technical
2aBAb10. Heterogenous angular spectrum approach-based holograms for trans-skull focused ultrasound therapy by Pradosh Pritam Dash from the Georgia Institute of Technology
2pBAb8. Dynamics of focused ultrasound-enhanced glymphatic transportation in the mouse brain by Yan Gong from Washington University in St. Louis
2pBAb9. Binary acoustic metasurfaces for transcranial focused ultrasound by Zhongtao Hu from Washington University in St. Louis
Breast
2aBAb3. Treatment of breast cancer with focused ultrasound: Opportunities and challenges by Allison Payne from the University of Utah
Cancer Immunotherapy
2aBAa6. Promoting immunotherapy of cancer with focused ultrasound by Richard J. Price from the University of Virginia
Cavitation
4aBAb. Making and Using Cavitation Images for Therapeutic Ultrasound I: Lecture session moderated by Meaghan O’Reilly (Sunnybrook Research Institute), Michael Gray (the University of Oxford), and Kevin Haworth (the University of Cincinnati)
4aBAb1. Desperate times call for disparate measures: Towards harmonization of cavitation data across environments and systems by Michael Gray from the University of Oxford
4aBAb2. Time-resolved passive cavitation mapping using the transient angular spectrum approach by Yun Jing from Pennsylvania State University
4aBAb3. Investigating the change in point spread function and resolution of random apodization passive cavitation images by Weston Gaskins from the University of Cincinnati
4aBAb5. PAM, not spam: Towards quantitative, reproducible, and energy-preserving cavitation imaging by Cameron Smith from the University of Oxford
4aBAb6. Experimental demonstration of 3D Passive Cavitation Imaging using adaptive beamforming by Barbara Nicolas from the University of Lyon
4aBAb7. Comparison of passive beamformers for isolating cavitation activity originating in the spinal canal by Andrew P. Frizado from the University of Toronto
4pBAb: Making and Using Cavitation Images for Therapeutic Ultrasound II: Lecture session moderated by Meaghan O’Reilly (Sunnybrook Research Institute), Michael Gray (the University of Oxford), and Kevin Haworth (the University of Cincinnati)
4pBAb1. Passive acoustic mapping within the cranial vault during microbubble-mediated ultrasound brain therapy by Ryan Jones from Sunnybrook Research Institute
4pBAb5. Real-time passive cavitation mapping with high spatial-temporal resolution by Junjie Yao from Duke University
4pBAb8. Monitoring cavitation dynamics evolution in tissue mimicking hydrogels for repeated exposures via acoustic cavitation emissions by Scott Haskell from the University of Michigan
Cellular Control
1aBAb1. Ultrasound modulation of neurons by sonogenetics by Hong Chen from Washington University in St. Louis
1aBAb2. Ultrasound-mediated control of neurons and immune cells by Costas Arvanitis from Georgia Institute of Technology
Central Nervous System
2pBAb2. Technological considerations for delivering focused ultrasound exposures to the spinal cord by Meaghan O’Reilly from Sunnybrook Research Institute
Eye
1pBAb1. Ultrasound-enhanced ocular drug delivery by Vesna Zderic from George Washington University
1pBAb2. Therapeutic ultrasound for enhanced transcorneal macromolecule delivery by Claire M. Allison from George Washington University
1pBAb3. Preliminary investigations on cavitation effects in the crystalline lens by Maxime Lafond from LabTAU
1pBAb6. Modulation of the blood-retina-barrier permeability by focused ultrasound: Computational and experimental approaches by Sam Bleker from the University of Applied Sciences and Arts in Gottingen
1pBAb7. Ultrasound cycloplasty for refractory glaucoma treatment: The EyeTechCare Experience by Dietrich Wolf from EyeTechCare
Gene or Drug Delivery
1aBAb10. Investigation of the ultrasound-mediated toxicity mechanisms of various sonosensitive drugs by Kritika Singh from the University of Oxford
2aBAa2. Gene and drug delivery using ultrasound-targeted microbubble cavitation by Flordeliza S. Villanueva from the University of Pittsburgh
2aBAa5. Combining stimuli-responsive colloids and focused ultrasound for drug delivery by Tyrone M. Porter from the University of Texas
2aBAb7. The efficiency of ultrasonic glymphatic manipulation–based intrathecal drug delivery depends on the physiological states by Muna Aryal from Loyola University Chicago
2pBAb6. Feasibility of MRI-guided focused ultrasound–mediated intranasal delivery in a large animal model by Siaka Fadera from Washington University in St. Louis
2pBAb7. MRI-guided focused ultrasound drug delivery to DMG tumors in a mouse model by Payton Martinez from the University of Colorado
Histotripsy
1aBAb8. An in-silico model of clot degradation under the action of histotripsy and thrombolytic drugs by Kenneth B. Bader from the University of Chicago
2aBAb8. In vivo soft tissue aberration correction for histotripsy using acoustic cavitation emissions by Ellen Yeats from the University of Michigan
2pBAb1. Instrumentation for histotripsy ultrasound therapy: Evolution toward the clinic by Timothy Hall from the University of Michigan
4aBAb4. Contrast-specific imaging of histotripsy: Chirp-coded subharmonic imaging combined with Volterra Filtering by Vishwas Trivedi from the Indian Institute of Technology
4pBAb6. Acoustic cavitation localization during histotripsy using transmit-receive capable arrays by Jonathan Sukovich from the University of Michigan
4pBAb7. Histotripsy of healthy and tendinopathic ex vivo bovine tendons by Julianna Simon from Pennsylvania State University
4pBAb9. Contribution of bubble activity to the efficacy of histotripsy and catheter-directed recombinant tissue plasminogen activator for treatment of porcine thrombi in vitro by Shumeng Yang from the University of Cincinnati
5aBAb8. A method to determine the bandwidth of imaging pulses for chirp-coded excitation imaging of histotripsy bubble clouds by Katia Flores Basterrechea from the University of Chicago
5aBAb9. Development of an optically transparent, tendon-mimicking hydrogel for histotripsy by Jacob Elliott from Pennsylvania State University
Kidney
2aBAb2. Office-based kidney stone management with new ultrasound technologies by Adam D. Maxwell from the University of Washington
2aBAb11. Design and fabrication of an acoustic tweezer system for kidney stone manipulation by Mohamed A. Ghanem from the University of Washington
Lung
3aBAa10. The vulnerable air-tissue interface: Summary of ultrasound-related bioeffects on lung and their implications for the use of different imaging modes and applications beyond by Frank Wolfram from the SRH Lung Cancer Center Gera, Germany
Peripheral Neuromodulation
5aBAb14. Effect of focused ultrasound peripheral nerve stimulation on muscle mechanical properties: An in vivo murine model by Jacob C. Elliott from Pennsylvania State University
Technology in General
2aBAb1. The Verasonics platform for ultrasound-guided focused ultrasound preclinical studies by Peter Kaczkowski and Juvenal Ormachea from Verasonics
2aBAb4. Fully electronically steerable high power ultrasound phased arrays for therapy—A review of progress by Kullervo Hynynen from the University of Toronto and Sunnybrook Research Institute
2aBAb5. Sound advice—Sound design by Mark E. Schafer from Drexel University
2pBAb4. Therapeutic ultrasound to market by Kyle P. Morrison and Francisco Chavez from Sonic Concepts
4aCA4. Large-scale simulation of high-intensity focused ultrasound with Sierra/SD by Benjamin Treweek from Sandia National Laboratories
5aBAa2. A preliminary numerical investigation of convolutional neural Network (CNN) techniques for filtering high-intensity focused ultrasound (HIFU) noise in images by Grace Farbin from the University of Toronto
Vascular
1pBAa1. Vortex ultrasound catheter for cerebral intravenous sonothrombolysis by Xiaoning Jiang from North Carolina State University
2pBAb5. Technology development for acoustic hemostasis by Lawrence A. Crum from Ultrasound Technologies
2pBAb12. Sonoreperfusion with fibrin-targeted phase shift microbubbles for the treatment of microvascular obstruction by Soheb Anwar Mohammed from the University of Pittsburgh
All abstracts and additional meeting information can be found in PDF format here.
The Foundation thanks Frank Wolfram, PhD, for researching and writing this meeting report.