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June 30, 2023
This issue features important news in the field of focused ultrasound neuromodulation, a mechanism in which ultrasound is used to stimulate or suppress nerve activity.
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- Researchers conducted a preclinical study to send rodents into a hibernation-like state called “torpor.”
- Mammals and some birds enter torpor to conserve energy in harsh environments.
- The effect was prolonged when controlled by an automated body temperature detector.
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- Applying focused ultrasound to the liver may improve diabetes symptoms.
- A recent Phase I clinical trial enrolled 16 participants with Type 2 diabetes.
- The treatment lowered fasting insulin levels and improved insulin resistance scores.
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- Sonic Concepts purchased an exclusive license for patents protecting ultrasound for neuromodulation.
- The portfolio includes low-intensity ultrasound neuromodulation techniques developed by Jamie Tyler, PhD.
- The company plans to commercialize the intellectual property for various indications.
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- Researchers conducted a preclinical study to determine the potential role of genetics in brain neuromodulation.
- They found that the mechanosensitive ion channel gene, Piezo1, mediated ultrasound neuromodulation.
- The protein encoded by Piezo1 is a mechanically activated ion channel that links mechanical forces to biological signals.
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- Sunnybrook’s Harquail Centre for Neuromodulation is the recipient of a new $12 million gift to advance neuromodulation therapies.
- The funds will be used to establish professorships, support learners, and advance vital research projects.
- The Harquail Centre has pioneered clinical research in focused ultrasound for Alzheimer's disease, ALS, Parkinson’s disease, depression, and OCD.
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“Focused ultrasound has the potential to address the long sought-after goal of achieving noninvasive and safe induction of the torpor-like state, which has been pursued by the scientific community at least since the 1960s.”
‒ Hong Chen, PhD |
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