Clinical Trial Results Published on Opening Blood-Brain Barrier

French device manufacturer CarThera published the results from its Phase I/IIa clinical trial using the SonoCloud-1 ultrasound implant to open the blood-brain barrier (BBB) prior to carboplatin chemotherapy in patients with recurrent glioblastoma (GBM).

Nature Communications published the findings of a clinical trial at Sunnybrook Health Sciences Centre in Toronto to assess the feasibility and safety of using focused ultrasound in patients with amyotrophic lateral sclerosis (ALS). The results showed it is possible to safely use MR-guided focused ultrasound to temporarily and reversibly open the blood-brain barrier (BBB) in patients with ALS.