This multicenter clinical trial is evaluating the safety of using focused ultrasound to temporarily and reversibly open the blood-brain barrier (BBB) in glioblastoma patients undergoing standard chemotherapy treatment.
Researchers hope that disrupting the BBB will enhance the delivery of chemotherapy to the tumor site.
The study at the University of Virginia is being led by Jason Sheehan, MD, PhD, Professor of Neurological Surgery and Neuroscience and the Foundation’s Senior Advisor for Brain Tumor Research.
The Foundation is contributing to this clinical trial through an ongoing partnership with the UVA Focused Ultrasound Center of Excellence.
Dr. Chong Kian Tai addressed focal therapy and focused ultrasound treatment of prostate cancer with the Singapore Cancer Society's prostate cancer support group.
Dr. Chong is a urologist at Mount Elizabeth Novena Hospital and Farrer Park Hospital.
Farrer Park Hospital is the only site in Singapore to offer the procedure as a standard-of-care treatment.
Professor Jürgen Götz’s group has published two preclinical studies using focused ultrasound to treat Alzheimer’s disease and the advanced effects of aging.
The Alzheimer's research included aducanumab, the first drug approved for the disease in the US in 20 years.
The aging study found low-intensity ultrasound could restore memory and cognition.
Researchers at Washington University in St. Louis sought to selectively and noninvasively target specific neurons to better understand brain function and treat brain disorders.
Applying focused ultrasound to engineered sonothermogenetic cells induced a safe thermal effect that produced expected behavioral responses.
Save the Date: Cavitation Monitoring and Dosimetry for Therapeutic Ultrasound Workshop
The Foundation and the American Institute for Ultrasound in Medicine are hosting a workshop on Cavitation Monitoring and Dosimetry for Therapeutic Ultrasound. The series of six virtual events will be held September 24 and October 1, 8, 15, 22, and 29 from 10:00 am – 1:00 pm Eastern. Topics include detection equipment, localization and mapping, thresholds and dosing, cavitation agents, and clinical and regulatory experiences.
