Sonic Concepts Helps Lead the Development of FUS Technology
George Keilman reviews work performed by process lab technician Vatsana Chansamphou
George Keilman is arguably one of the most successful entrepreneurs in focused ultrasound. With a lifelong passion for acoustics that led him to buy his first book on ultrasound when he was 15, we should not be surprised.
His company, Sonic Concepts, has been a world leader in developing, testing, and manufacturing focused ultrasound devices for more than 25 years. At any given time, they are overseeing 20 to 30 development projects for academic research laboratories, start-ups, and established commercial companies from around the globe.
Mr. Keilman recently visited the Foundation to talk about the latest developments in the technology, the state of the field, and the future of the industry. Our interview with him begins here and continues with a company profile in the Industry News section.
Q. How did you get started in focused ultrasound? A. I studied ultrasound while in graduate school for electrical engineering at the University of Washington. Early in my career I worked in diagnostic ultrasound, which evolved over time into therapeutic ultrasound, and eventually focused ultrasound. Sonic Concepts was born in 1989 as a consulting business doing transducer development, and we quickly evolved into prototyping, and eventually manufacturing of devices. Virtually everything we do has an ultrasound component to it – from small ultrasound catheters to large focused ultrasound devices.
Q. Where do you think the industry is heading? A. The potential for focused ultrasound is great...
Give to help catalyze additional investment from industry, government, and other philanthropies to carry the technology forward.
Donations Needed to Fulfill $1 Million Matching Gift from Leading Educational Trust
The Focused Ultrasound Foundation is grateful to start 2015 with a generous donation from the William R. Kenan, Jr. Charitable Trust. The Trust has pledged a 3:1 unrestricted matching gift in the amount of $250,000.The Foundation is now seeking $750,000 in unrestricted donations to complete this gift.
The Trust was founded by William R. Kenan, Jr., a leading industrialist and champion of innovation, for the principle purpose of supporting education.“The Focused Ultrasound Foundation is a pioneering philanthropy with the potential to revolutionize the medical landscape,” said the Kenan Charitable Trust’s Executive Director. “We hope that this matching gift will inspire additional donations, and that it will help to accelerate access to new treatment options for patients around the world.”
By giving today, you can multiply your impact. Your donation will help ensure that the Kenan Charitable Trust’s grant is matched. GIVE NOW >
“I am pleased to join the Focused Ultrasound Foundation’s circle of advocates and donors. It is rewarding to know that my contributions will advance the Foundation’s revolutionary work, fostering collaboration between stakeholders in the medical community, creating knowledge through cutting-edge research, and cultivating the next generation of clinicians and scientists.” – David L. Bernd, CEO of Sentara Healthcare
On the heels of a fantastic meeting last October, we are excited to announce the 5th International Symposium on Focused Ultrasound will take place August 28-September 1, 2016 at the North Bethesda Marriott Hotel and Conference Center in Bethesda, Maryland. Mark your calendar now, and join us to hear the latest in focused ultrasound preclinical, translational, and clinical research from leading experts in the field.
Focused Ultrasound: The Clinical Possibilities Beyond Ablation
Council Member Meredith Woo to Lead Higher Education Program at the Open Society Foundations
The Focused Ultrasound Foundation will have a new global ambassador as Council member Meredith Jung-En Woo, PhD joins the Open Society Foundations (OSF) as Director of the grant-making network’s International Higher Education Support Program. She will be based in London overseeing the program’s efforts to support higher education and promote open society in countries transitioning to democracy, particularly in Asia, Latin America, and the Middle East.
OSF works within local communities in more than 100 countries to build vibrant and tolerant democracies whose governments are accountable to their citizens. It was founded by George Soros, who remains deeply engaged.
Earlier this month, we announced the sudden and unexpected passing of focused ultrasound pioneer Ferenc A. Jolesz, MD, Professor of Radiology at Harvard Medical School and the Vice Chair of Radiology Research and Director of the Image Guided Therapy Program at Brigham and Women's Hospital. Dr. Jolesz was a mentor, friend, and world class visionary whose passion for pushing surgery into the 21st century led him from developing image-guided minimally invasive therapy to engineering focused ultrasound as a completely non-invasive approach.
As part of our mission to serve as a hub within the focused ultrasound community, we have now expanded the Job Opportunities section of our website to include position announcements and job seekers from around the world.
Job Seekers: Check this page for new postings--or post your resume if you are actively seeking employment.
Companies/Universities/Clinicians: To post a listing, email c.
Focus on Your Social Life in 2015
Did you know that we’ve had more than 300 views in the past month on the Foundation’s YouTube Channel? That we are nearing our 1,000th tweet on Twitter? And that we have more than 1,000 followers on Facebook? Join the focused ultrasound conversation!
"There is great potential to treat advanced cancer more precisely and with limited systemic toxicity." – Jessica Foley, PhD, FUSF’s Scientific Director
Celsion Focused Ultrasound Symposium Highlights Cancer Studies
On Friday, January 16th, Celsion Corporation hosted a symposium in New York to highlight cutting edge translational research involving ThermoDox (a thermally sensitive liposomal chemotherapeutic product) in combination with high intensity focused ultrasound (HIFU). The meeting brought together 20 international scientists and clinicians who are leading the development of this combination approach (HIFU + ThermoDox) toward clinical application for treatment of a variety of cancers. Current preclinical studies are ongoing for tumors of the breast, pancreas, liver, brain, and soft tissues. Phase 1 clinical trials have been initiated for HIFU-ThermoDox treatment of liver (Oxford) tumors. A phase 1 clinical trial in breast tumors (Utrecht) is also planned.
ThermoDox is a liposomal product that encapsulates doxorubicin as it circulates throughout the body. The liposome is thermally sensitive and will release its encapsulated doxorubicin payload when heated to temperatures above 40 degrees. Therefore, focal heating at the tumor site with HIFU will enable targeted, local release of high concentrations of doxorubicin within the tumor.
Paul Dayton, PhD
External Research Award Update
Nanodroplets Enhance Focused Ultrasound Ablation
Last August, we profiled external award recipient Paul Dayton, PhD and the nanodroplet research being conducted by his team at the Joint Department of Biomedical Engineering at the University of North Carolina Chapel Hill and North Carolina State University, Raleigh. The project is now complete, and several scientific publications document this important work. The group found that the use of nanodroplets could potentially reduce focused ultrasound procedure times as much as five-fold by more safely and quickly ablating a larger region of tissue.
"This work is an example of how basic research can demonstrate a clear clinical benefit. Shortening focused ultrasound treatment times is important to patients, physicians, and treatment facilities." – Matt Eames, PhD, FUSF's Director of Extramural Research
As we begin the new year, we encourage you to mark your calendars for these important meetings. You’ll have the opportunity to share the latest focused ultrasound research, collaborate with leaders in the field, and brainstorm new ideas.
Winter School on Therapeutic Ultrasound: March 8-13, 2015
15th International Symposium on Therapeutic Ultrasound (ISTU): April 15-18, 2015
3rd European Symposium on Focused Ultrasound Therapy: October 15-16, 2015
During the recent visit from Sonic Concepts’ Founder and President, George Keilman, we asked about the creation, technological advancements, and new applications of the company. Founded in 1989 and based in Bothell, Washington, Sonic Concepts designs and manufactures ultrasonic transducers and systems. They currently employ 14 people, and their intellectual property portfolio is approaching 30 US patents. Besides the single element and array transducers used for focused ultrasound, their products include imaging probes, hydrophones, software, and focused ultrasound system accessories like water degassing systems, radiation force balance equipment, watt meters, coupling cones, and more.
We congratulate EDAP-TMS on their Focal One device being approved by Health Canada, enabling the company to market the device for the treatment of prostate cancer. European approval was granted in 2013. EDAP's Chief Executive Officer, Marc Oczachowski, commented that this important milestone "is the first regulatory approval for Focal One in the Americas and a key step forward in our overall regulatory strategy as we work to expand Focal One's global footprint and bring our innovative cancer therapies to a growing number of patients worldwide."