- The 182nd meeting of ASA was held May 23–27, 2022, in Denver, Colorado.
- Sessions related to focused ultrasound included bacterial infections, brain, cardiovascular, drug delivery, cancer immunotherapy, musculoskeletal, oncology, optic, renal, and technical applications.
- Meaghan O’Reilly, PhD, received the R. Bruce Lindsay award for contributions to biomedical ultrasound applications in the central nervous system.
The 182nd Meeting of the Acoustical Society of America (ASA) was held May 23–27, 2022, in Denver, Colorado. ASA holds two large meetings each year, and each features presentations on a wide variety of the scientific, medical, and industrial aspects of sound. The sessions that may be of particular interest to the focused ultrasound community are listed below and include bacterial infections, brain, cardiovascular, drug delivery, cancer immunotherapy, musculoskeletal, oncology, optic, renal, and technical applications.
Meaghan O’Reilly, PhD, a Senior Scientist at Sunnybrook Research Institute and Associate Professor of Medical Biophysics at the University of Toronto, received the R. Bruce Lindsay award for contributions to biomedical ultrasound applications in the central nervous system. This award is presented to an ASA member who has been active in the affairs of the society and has contributed substantially, through published papers, to the advancement of theoretical or applied acoustics, or both. Eligible members must be no more than 10 years post terminal degree at the time of award acceptance.
“Attending the ASA Denver meeting was a great experience,” said Dr. O’Reilly. “The R. Bruce Lindsay award brought great recognition to our work and more broadly to the field of focused ultrasound. There were many excellent presentations from those working in the focused ultrasound field, all of which were well received by the ASA community.”
All abstracts are available on the ASA abstract site. The following 36 presentations addressed various applications of therapeutic ultrasound:
Bacterial Infection (2)
- 2pBAa4. Inactivation of Gram Positive or Gram Negative Microbes Using Different Histotripsy Regimes by Pratik Ambekar, Yak-Nam Wang, Tatiana Khokhlova, Daniel Leotta, Ekaterina Kuznetsova, Matthew Bruce, and Thomas Matula from the Applied Physics Laboratory and the Department of Medicine, University of Washington, Seattle, Washington, United States
- 3aBA8. Microbubble-Mediated Adjunct Treatment for Cardiovascular Bacterial Infections by Kirby Lattwein, Margot Starrenburg, Joop Kouijzer, Mariël Leon-Grooters, Moniek de Maat, Willem van Wamel, and Klazina Kooiman from the Biomedical Engineering, Hematology, and Medical Microbiology and Infectious Diseases Departments of Erasmus University Medical Center, Rotterdam, The Netherlands
- 2pBAa1. Ultrasound and Microbubble-mediated Blood-Brain Barrier Disruption: Pre-Clinical Best Practices by Nicholas Ellens from Acertara Acoustic Labs, Longmont, Colorado, United States
- 3aBA1. Bubble-Vessel Interactions: From Physics to Applications in Brain Disease Theranostics by Hong Chen from Washington University in St. Louis, St. Louis, Missouri, United States
- 3aBA3. Ultrasound-Targeted Microbubble Cavitation Increases Paracellular Gaps in an In Vitro Blood-Brain Barrier Model by Grace Conway, Anurag Paranjape, Xucai Chen, and Flordeliza Villanueva from the University of Pittsburgh, Pittsburgh, Pennsylvania, United States
- 3aBA4. Microbubble Dynamics in Brain Microvessels at 1 MHz and 330 kHz Driving Frequencies by James Bezer, Paul Prentice, William Lim Kee Chang, Zheng Jiang, Sophie Morse, Christopher Rowlands, Kirsten Christensen-Jeffries, Andrei Kozlov, and James Choi from Bioengineering, Imperial College London, Oxford, United Kingdom; University of Glasgow, Glasgow, United Kingdom; and Biomedical Engineering and Imaging Sciences and Bioengineering, King’s College London, London, United Kingdom
- 3aBA5. Focused Ultrasound Effects on the Glioblastoma Immune Microenvironment by Tao Sun and Nathan McDannold from Radiology, Brigham and Women’s Hospital, Harvard Medical School, and Tufts University, Boston, Massachusetts, United States
- 3aBA6. A 3-Dimensional Human Brain Spheroid Model for Studying Sonoporation-Induced Drug Penetration Beyond the Blood-Brain Barrier by Anurag Paranjape, Leonardo D’Aiuto, Wenxiao Zheng, Xucai Chen, and Flordeliza Villanueva from UPMC Heart and Vascular Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, United States and the Department of Psychiatry, University of Pittsburgh School of Medicine Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania, United States
- 3aBA7. Assessment of Clot Degradation Under the Action of Histotripsy and a Thrombolytic Drug by Samuel Hendley and Kenneth Bader, University of Chicago, Chicago, Illinois, United States
Drug Delivery and Cancer Immunotherapy (10)
- 1aBA5. Calibration of a Focused Passive Cavitation Detector using Bubble Shock Waves by Krit Sujarittam and James Choi from Imperial College London, London, United Kingdom
- 1aPAb4. Probing the Mechanisms of Sonodynamic Therapy by Eleanor Stride, University of Oxford, Oxford, United Kingdom
- 2aBAb4. Bubble-Based Propulsion of Engineered Particles for Drug Delivery and Immunotherapy by Wyatt Shields, Andrew Goodwin, Taylor Ausec, and Jin Lee from Chemical and Biological Engineering, University of Colorado Boulder, Boulder, Colorado, United States
- 3aBA2. Ultrasound-Enhanced Drug Delivery to Spinal Cord Tumors by Paige Smith, Min Choi, Danielle Charron, Ranjith Ramesh, and Meaghan O’Reilly from Sunnybrook Research Institute, Toronto, Ontario, Canada
- 3aBA11. Exploration of Ultrasound-Mediated Microbubble-Cell Membrane Interactions using Novel Protein-Loaded Microbubbles and Their Role in Immunomodulation by Veerle Brans, Michael Gray, Erdinc Sezgin, and Eleanor Stride from the Institute of Biomedical Engineering, University of Oxford, Oxford, United Kingdom, and SciLifeLab, Karolinska Institutet, Solna, Sweden
- 3pBAa1. Characterization of Microbubble-Enhanced Molecular Delivery to Cells in Acoustofluidic Channels by Jonathan Kopechek from Bioengineering, University of Louisville, Louisville, Kentucky, United States
- 3pBAa2. Use of Static Overpressure to Assess the Role of Acoustic Cavitation in Ultrasound-Mediated Gene Transfection by Chun Kiat Ng, Jason Raymond, Claudia Driscoll, Sophie Oldroyd, Wei Huang, Ian Thompson, and Ronald Roy from the Department of Engineering Science, University of Oxford, Oxford, United Kingdom
- 3pBAa3. Ultrasound-Assisted Membrane Permeabilization of Endothelial Cells Under Flow Conditions by Elahe Memari, Fiona Hui, Brandon Helfield from Physics and Biology, Concordia University, Montreal, Quebec, Canada
- 3pBAa4. Microbubble-Endothelial Cell Interactions in 3D: Internalization of Microbubbles and Pore or Tunnel Formation for Drug Delivery by Ines Beekers, Simone A.G. Langeveld, Bram Meijlink, Antonius van der Steen, Nico de Jong, Martin Verweij, and Klazina Kooiman from Biomedical Engineering, Erasmus MC, Rotterdam, The Netherlands and Imaging Physics, Delft University of Technology, Delft, The Netherlands
- 3pBAa5. The OrganoPlate® as Vessel-On-A-Chip Model to Investigate Increased Microbubble-Mediated Vascular Permeability by Bram Meijlink, Ines Beekers, Simone A.G. Langeveld, Kristina Bishard, Antonius van der Steen, Nico de Jong, Sebastiaan J. Trietsch, and Klazina Kooiman from Biomedical Engineering, Erasmus MC, Rotterdam, The Netherlands and Mimetas, Leiden, Zuid-Holland, The Netherlands
- 1aBA8. Histotripsy Bubble Dynamics in Tendon and Anisotropic Gel Phantoms by Jacob Elliott, Andrea Arguelles, and Julianna Simon from Engineering Science and Mechanics and Graduate Program in Acoustics, Pennsylvania State University, University Park, Pennsylvania, United States
- 4aBA9. Comparison Between Focused Ultrasound and Dry Needling Treatments in a Murine Achilles Tendinopathy Model by Molly Smallcomb, Sujata Khandare, Jacob Elliott, Meghan Vidt, and Julianna Simon from Pennsylvania State University, State College, Pennsylvania, United States
- 2aBAb2. Ultrasound-Stimulated, Drug-Loaded Bubbles for Cancer Therapy by Naomi Matsuura from Biomedical Engineering/Materials Science & Engineering, University of Toronto, Toronto, Ontario, Canada
- 2aBAb3. Acoustic Droplet Vaporization and Gas Embolotherapy by Joseph Bull from Biomedical Engineering, Tulane University, New Orleans, Louisiana, United States
- 2aBAb8. Optimization of Cavitation-Mediated mRNA Delivery to Cancer and Non-Cancer Cells in Vitro and in Vivo by Alexander Martin, Cameron Smith, Robert Carlisle, Robin Cleveland, and Constantin Coussios from the Institute of Biomedical Engineering, University of Oxford, Oxford, United Kingdom
- 2aBAb6. Effectiveness of 3 MHz Ultrasound in Ex-vivo Scleral Delivery of Macromolecules of Different Sizes by Hanaa Almogbil, Fadi P. Nasrallah, Vesna Zderic from the School of Engineering and Applied Science, George Washington University and Retina Consultants, Washington, District of Columbia, United States
- 2aBAb7. Feasibility of Cavitation Nucleation in the Crystalline Lens by Alice Ganeau, Maxime Lafond, Olfa Ben Moussa, Charles Mion, Sylvain Poinard, Frédéric Mascarelli, Stefan Catheline, Gilles Thuret, Philippe Gain, Cyril Lafon from LabTAU – INSERM U1032, Lyon, France, and Laboratoire de Biologie, Ingénierie et Imagerie de la Greffe de Cornée (BiiGC), Université Jean Monnet, Saint-Etienne, France
- 2aPAb1. Designing an Array for Acoustic Manipulation of Kidney Stones by Mohamed Ghanem, Adam Maxwell, Oleg Sapozhnikov, and Michael Bailey from the Center for Industrial and Medical Ultrasound, Applied Physics Lab and Department of Urology, University of Washington, Seattle, Washington, United States
- 1aBA3. Predicting Acoustic Emissions of Ultrasound-Driven Lipid-Coated Microbubbles by Sören Schenke, Rishav Saha, and Fabian Denner from Otto-von-Guericke-University Magdeburg, Magdeburg, Germany
- 1aBA7. The Effect of Stiffness and Impurities on Bubble Nucleation in Polyacrylamide Hydrogels by Ferdousi Sabera Rawnaque and Julianna Simon from the Graduate Program in Acoustics, Pennsylvania State University, University Park, Pennsylvania, United States
- 1aBA11. Passive Cavitation Detection with a Needle Hydrophone Array by Zheng Jiang, Krit Sujarittam, Betul Ilbilgi Yildiz, Robert Dickinson, and James Choi from the Department of Bioengineering, Imperial College London, London, United Kingdom
- 1aBA12. The Use of Real-time Passive Cavitation Imaging for Monitoring Boiling Histotripsy Treatments by Gilles Thomas, Alex Peek, Tatiana Khokhlova, and Vera Khokhlova from the Applied Physics Laboratory and the Department of Medicine, University of Washington, Seattle, Washington, United States and the University of Washington/Moscow State University, Moscow, Russian Federation
- 1aSA4. Nonlinear Elastic Metamaterials as Pulse Shaping Devices for Shock Test Applications by Samuel Wallen, Michael Haberman, and Washington DeLima from Applied Research Laboratories and the Walker Department of Mechanical Engineering, University of Texas at Austin, Austin, Texas, United States, and Honeywell‚ Federal Systems, Kansas City, Missouri, United States
- 3aBA9. The Spatial Distribution of the Ligand on Targeted Microbubbles Influences the Binding Efficacy by Simone A.G. Langeveld, Bram Meijlink, Ines Beekers, Mark Olthof, Antonius van der Steen, Nico de Jong, and Klazina Kooiman from Biomedical Engineering, Erasmus MC, Rotterdam, The Netherlands
- 3aBA10. Ultra-High Speed Quantification of Cell Strain During Cell-Microbubble Interactions by Oliver Pattinson, Dario Carugo, Fabrice Pierron, and Nicholas Evans from the Faculty of Engineering and Physical Sciences, University of Southampton, Southampton, Hampshire, United Kingdom, and the Department of Pharmaceutics, School of Pharmacy, University College London, London, United Kingdom
- 3aBA12. Quantifying the Role of Microstreaming in Sonoporation by Miles Aron and Eleanor Stride from the University of Oxford, Oxford, United Kingdom
- 3pBAa6. Correlating High-Speed Optical Imaging and Passive Acoustic Mapping of Cavitation Dynamics by Qiang Wu, Michael Gray, Cameron Smith, Luca Bau, Constantin Coussios, and Eleanor Stride from the Institute of Biomedical Engineering, University of Oxford, United Kingdom
The Foundation thanks Dr. O’Reilly for her assistance in writing this meeting report.