Key Points
- The 2024 Histotripsy Symposium was held June 17–19 in Minneapolis, MN.
- A comprehensive lineup of presentations and posters showcased the ongoing preclinical and clinical development of the technology.
The 2024 Histotripsy Symposium took place from June 17–19 in Minneapolis, MN. It was hosted by the University of Wisconsin. Clinicians, engineers, researchers, and industry representatives met to discuss and advance the emerging field of histotripsy—a noninvasive focused ultrasound technique.
Timothy Hall, PhD, one of the original developers of histotripsy at the University of Michigan, delivered the Charles Cain Keynote Lecture. In “The Year in Review with a Look to the Future,” Dr. Hall shared future directions for histotripsy, including how instrumentation and applications are evolving and how histotripsy is evolving in cancer treatment and immuno-oncology.
The symposium’s themed sessions featured additional prominent speakers, including Andrew von Eschenbach, MD, president of Samaritan Health Initiatives. See the full program.
Beyond listening to the invited speakers, attendees engaged in hardware and software demonstrations, poster presentations, and a tour of HistoSonics.
Histotripsy is being developed in both clinical and preclinical settings. The 11 oral abstracts and 27 posters presented at the symposium illustrated the expanding applications of histotripsy, from targeted cancer therapies and osteosarcoma ablation to novel applications in biofilm disruption and bone tissue research. Each abstract is listed below by topic.
Immune Oncology Abstracts (2)
- The impact of histotripsy dosages on tumor control and immune response in a murine melanoma model by Reliza McGinnis, student, University of Michigan
- The Effect of Transcranial Histotripsy Dosage on Immune Cell Infiltration in Murine Glioblastomas by Sarah Duclos, BME PhD Student, University of Michigan
Technology Abstracts (5)
- A Pre-Clinical MR-Guided All-in-One Focused Ultrasound System for Murine Brain Studies by Tarana Parvez Kaovasia, University of Michigan
- Advancing CBCT-Guided Histotripsy with Injectable X-Ray Visible Pseudotumor Targets for Preclinical Research by Katrina Falk, University of Wisconsin
- Evaluation of Histotripsy in the Ureter and Renal Pelvis in a Porcine Survival Model by Adrienne Kisting, MS, University of Wisconsin
- Bandwidth Limited, Large Aperture, Active Acoustic, Spatio-Temporal Mapping (BLAST) of Multi-Bubble Cavitation Events by Mahmoud Komaiha, University of Michigan
- Tissue Selective Liver Ablation – Towards Decellularization: An Ex Vivo Parameter Study by Sara Elnahhas, Virginia Tech
Developing Indication Abstracts (4)
- Histotripsy for the Treatment of Oral Tumors: A Canine Ex Vivo Feasibility Study by Victor Lopez, Virginia Tech
- Histotripsy of the Stomach Wall and Liver in an Acute Swine Model by Meridith Kisting, MA, University of Wisconsin
- A Custom Image-Guided Histotripsy Endoscope for the Treatment of Obstructive Sleep Apnea by Alyssa Forbes, Dalhousie University
- Development of Histotripsy for the Treatment of Osteosarcoma: Findings from Canine Clinical Trials at the Virginia Tech Animal Cancer Care and Research Center by Elliana Vickers, Virginia Tech
Posters (27)
- Decalcification of Thinned Rodent Skull for Transcranial Ultrasound Imaging and Histotripsy by Thomas Landry, PhD, Dalhousie University
- Applying a Bubble-Removal Pulse to Improve Histotripsy Treatment of Biofilms by Timothy Bigelow, PhD, Iowa State University
- Applications of Histotripsy Towards Neuroblastoma by Kenneth Bader, PhD, University of Chicago
- Investigating Histotripsy Treatment Damage Monitoring using Ultrasound Shear Wave Elastography in the In-vivo Murine Colorectal Tumors by Hanna Kim, University of Michigan
- Histotripsy Dose Monitoring via Acoustic Cavitation Emissions (ACE) by Scott Haskell, University of Michigan
- Histotripsy Under the Microscope by Christina Hendren, University of Michigan
- Ultrasound-Guided Histotripsy for Feasibility of Non-Invasive Treatment of Soft Tissue Sarcoma by James Messina, University of Michigan
- Soft Tissue Aberration by Ellen Yeats, PhD, University of Michigan
- MR-guided Orthotopic Murine Histotripsy System by Ryan Hubbard, University of Michigan
- Histotripsy of Gas-Filled Ex Vivo Swine Bowel by Meridith Kisting, MA, University of Wisconsin
- Renal Bleeding Events with Histotripsy vs. Cryoablation in a Porcine Survival Model by Allison Couillard, MD, University of Wisconsin
- Liver Histotripsy: Jet Ventilation Decreases the Effect of Respiratory Motion in a Porcine Liver Model by John Winterholler MD, University of Wisconsin
- Cone-Beam Computed Tomography (CBCT)–Guided Histotripsy by Katrina Falk, University of Wisconsin
- Towards Advanced Treatment Planning for CBCT-Guided Histotripsy: FEM Deformable Liver Registration by Grace Minesinger, University of Wisconsin
- Investigation of the Immunomodulatory Outcomes associated with Histotripsy Ablation of Osteosarcoma by Alayna Hay, PhD, Virginia Tech
- Design and Development of Single Element Histotripsy Transducers using Rapid Prototyping Methods by Neffisah D’odoo, MS, Virginia Tech
- Exploring High PRF Histotripsy Pulsing Methods for the Ablation of Uterine Fibroids by Juliet Suen, Virginia Tech
- Comparative Study of Fluid-Filled and Solid Histotripsy Cavitation Agents by Isabel Quintana, Virginia Tech
- Histotripsy Ablation of Pancreatic Tumors in an In-Vivo Murine Model Affects the Tumor Microenvironment and Associated Immunological Pathways by Tamalika Paul, Virginia Tech
- Histotripsy Treatment of Biofilms on Cobalt-Chrome and Titanium Surgical Implants by Justin Howe, Virginia Tech
- Developing Robotically-Guided Histotripsy Systems for the Precise, Complete, and Non-invasive Ablation of Osteosarcoma Tumors by Thomas Lu, Virginia Tech
- Nanoparticle-Mediated Histotripsy for the Targeted Ablation of Breast Cancer by Sarah Hall, Virginia Tech
- Investigating Histotripsy as a Therapeutic and Immunomodulatory Strategy for Breast Cancer by Ruth Mtuwa, Virginia Tech
- Acoustic Properties of an Iron-Based Coupling Medium for MRI-Guided Transcranial Focused Ultrasound Procedures by Nathan Sambo, Virginia Tech
- Development of High-Rate, Single-Cycle Histotripsy Methods for Soft Tissue Ablation by Alexander Simon, Virginia Tech
- Focused Ultrasound Extraction (FUSE) for Rapid DNA Release from Complex Tissue Matrices by Alexia Stettinius, Virginia Tech
- Histotripsy for the Treatment of Oral Tumors: A Canine Ex Vivo Feasibility Study by Dana Wang, Virginia Tech
The next Histotripsy Symposium will be held in 2026.