September 15, 2022 - First Parkinson's Trial to Deliver Therapeutics – and more news…

The results of an early-stage clinical trial in Toronto...
September 15, 2022

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Focused Ultrasound for Parkinson’s Disease: Results of First Clinical Trial to Deliver Therapeutics
  • The results of an early-stage clinical trial investigating focused ultrasound to address a possible underlying cause of Parkinson’s disease were published in Movement Disorders.
  • Researchers in Toronto tested the safety and efficacy of focused ultrasound–induced blood-brain barrier opening to deliver enzyme replacement therapy.
  • The procedure was well-tolerated, and a larger study is being planned.
Foundation News
Register Now: Webinar on Focused Ultrasound and Alzheimer’s Disease
  • Join us September 20 at 10:00 am Eastern for “Focused Ultrasound and Alzheimer’s Disease: Using Sound to Deliver Drugs to the Brain.”
  • Sandra Black, MD, renowned neurologist and senior scientist at Sunnybrook Research Institute, will be the primary speaker.
  • The Foundation is partnering with USAgainstAlzheimer’s and the Global Alzheimer’s Platform Foundation.

Lorraine Spurge Joins Foundation’s Council
  • Lorraine Spurge has more than 40 years of business and financial experience.
  • She is the Senior Managing Partner of Hamilton Wealth Group, LLC, a multi-family office that invests in growth companies.
  • The Council is a dedicated group who provide advice and assist with raising funds and building awareness.

New Interactive Map Provides Global Perspective on Focused Ultrasound
  • A new tool has been developed to help patients, scientists, and other stakeholders locate focused ultrasound treatment and research sites around the world.
  • We thank musician and Council member Peter Gabriel for the idea!

Advocacy Partner Highlights Government Bioscience Funding Opportunities
  • The Foundation has partnered with G2G Consulting to provide monthly reports on government bioscience grants – the GBG Report.
  • This effort is part of an ongoing partnership to drive impact for the focused ultrasound community through advocacy.
  • Connect with G2G at the Symposium! Contact Katie Collins

Last Day to Apply: Andrew J. Lockhart Postdoctoral Fellowship in Focused Ultrasound and Immuno-Oncology
  • This one-year fellowship will pair an early-career scientist with leading laboratories to foster focused ultrasound and immuno-oncology research.
  • The award includes a $75,000 stipend.
  • The deadline to apply is tomorrow, September 16.
Symposium News
Register Now for In-Person or Virtual Attendance
  • Symposium 2022 will be a hybrid meeting with in-person and virtual attendance options.
  • Attendees can plan to join for the full meeting or participate on a day-by-day basis.
  • There are also discounted rates for students.

Hotel Rates Increase This Month
  • Meeting attendees can book a room at the Symposium hotel for a reduced rate of $259 per night.
  • The deadline to book at the lowest rate is September 26.
  • Join us at the Bethesda North Marriott Hotel and Conference Center in Bethesda, Maryland, USA.

Professor Zhibiao Wang to Receive Inaugural Clinical Adoption Award
  • Prof. Wang is founder and chairman of Chongqing Medical Focused Ultrasound Technology Development Co., Ltd.
  • During his 34-year career in therapeutic ultrasound, he has made pioneering contributions to the field.
  • The award recognizes an individual whose efforts have advanced the field and led to a significant number of patient treatments.

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Patient News
Glioblastoma Patient is Optimistic After Focused Ultrasound
  • Three years ago, Rick was diagnosed with a deadly brain tumor.
  • He participated in an early-stage focused ultrasound clinical trial at the University of Maryland and is currently cancer free.
  • Doctors are encouraged but cannot say that he is cured or that his cancer will not return.

More Patient News
Sunnybrook Leading Research in Focused Ultrasound | CTV News Toronto [video]
Explainer | Fibroid Surgery Alternative to Relieve Period Pain, HIFU Treatment – Also Used to Slow Skin Ageing – is Non-Invasive and Leaves No Scars | South China Morning Post
Research News
Liver Tumor FUS Histotripsy Trial Results: Treatment is Safe and Predictable
  • A new publication provides data to demonstrate that the first-in-human histotripsy treatment for liver tumors was safe and predictable in all eight patients.
  • The clinical trial was performed in Spain with HistoSonics’ prototype focused ultrasound system.
  • Larger clinical trials, called #HOPE4LIVER, are now underway in the US and Europe.

Improving Focused Ultrasound Brain Treatments with MRI Imaging
  • Researchers investigated whether MRI images could be used instead of CT images to calculate the skull corrections needed during focused ultrasound brain treatments.
  • The group determined that MRI could effectively be used to create MR-simulated CT images.
  • Making this change could ultimately help eliminate the cost and radiation exposure associated with CT scans.

Focused Ultrasound—Enhanced Drug Delivery Using the Glymphatic System
  • Researchers recently published the results from a preclinical study on focused ultrasound–enhanced intrathecal drug delivery to the brain.
  • Intrathecal transfer uses the glymphatic system – which is responsible for clearing waste using perivascular channels.
  • The focused ultrasound protocol was successful, safe, and significantly effective for increasing the uptake of small molecules in the brain.

Register Now: Webinar on How to Access US Department of Defense Grants
  • Join us September 22 at 1:00 pm Eastern for a webinar on the Department of Defense’s Congressionally Directed Medical Research Program (CDMRP).
  • Participants will learn how to apply for funding for focused ultrasound research projects.
  • The event is hosted by the Foundation and G2G Consulting.

US Policy Changes Encourage Access to Federally Funded Research
  • The White House Office of Science and Technology Policy (OSTP) recently updated US policy to make the results from federally funded research publicly available at no cost.
  • This ruling ends the current 12-month embargo period.
  • All agencies will fully implement the updated policy by 2026.

More Research News
SonALAsense Forges Ahead with First Patient Dosing for Devastating Childhood Brain Cancer | SonALAsense | Read the Trial Announcement >
Best Life: A New Procedure Called ‘PING’ Can Non-Invasively Remove Faulty Brain Cells | Action 5 News (Memphis)
West Virginia University Rockefeller Neuroscience Institute Expands Groundbreaking Alzheimer’s Research in Latest Trial | West Virginia University
Focused Ultrasound Summer Program Provides High School Students with Unique Hospital-Based Research Experience | Sunnybrook Research Institute
Industry News
Company Profile: Arrayus Technologies Inc.
  • Arrayus Technologies Inc., is a Canadian company developing a noninvasive focused ultrasound therapy platform to revolutionize cancer care.
  • We spoke with Arrayus’ President and CEO, James O’Reilly, about the company’s current trials and next steps.
  • The company was formerly known as Harmonic Medical.

Patent Strategy for Business Advantage: Insights for Focused Ultrasound Manufacturers
  • In this blog post, the Foundation’s Chief Technology Officer, Rick Hamilton, discusses patent strategies applicable to the focused ultrasound industry.
  • He addresses which companies should apply for patents and the various protections they afford.

More Industry News
Profound Medical Provides TULSA-PRO® Reimbursement Update | Globe Newswire
Insightec Announces Financing up to US$200 Million to Support Continued Growth | NeuroNews International
Focused Ultrasound and Alzheimer’s Disease: Using Sound to Deliver Drugs to the Brain
  • Tuesday, September 20 at 10:00 am Eastern
  • Featuring Sandra Black, MD, Nir Lipsman, MD, PhD, and Arjun (JJ) Desai, MD
  • Hosted by the Focused Ultrasound Foundation, UsAgainstAlzheimer’s, and the Global Alzheimer’s Platform Foundation

Webinar on How to Access US Department of Defense Grants
  • Thursday, September 22 at 1:00 pm Eastern
  • Learn about the Department of Defense’s Congressionally Directed Medical Research Program (CDMRP) and tips for securing research funding
  • Hosted by the Focused Ultrasound Foundation and G2G Consulting

Recent Webinars & Podcasts
Making Gas to Remove Gas: Acoustic Droplet Vaporization for Reperfusion Injury | Kevin J. Haworth, PhD, FAIUM, from the University of Cincinnati | Hosted by the International Society for Therapeutic Ultrasound

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Upcoming Events
September 26-28, 2022 Society for Pediatric Interventional Radiology, Galway City, Ireland

September 26-28, 2022 iTRUSST - 3rd Focused Ultrasound Neuromodulation Symposium (FUN) 2022, Mainz, Germany and VIRTUAL

October 10-13, 2022 IEEE International Ultrasonics Symposium, Venice, Italy and VIRTUAL

October 13-15, 2022 Veterinary Cancer Society Annual Conference 2022, Norfolk, VA

October 23-27, 2022 8th International Symposium on Focused Ultrasound, Bethesda, MD and VIRTUAL | Important Date Change

November 16-20, 2022 Society for Neuro-Oncology (SNO) Annual Meeting, Tampa Bay, FL

December 5-9, 2022 Acoustical Society of America (ASA) Annual Meeting, Nashville, TN 

December 8-11, 2022 International Symposium on Biomolecular Ultrasound and Sonogenetics (ISBUS), Pasadena, CA 

January 19-23, 2023 Society of Interventional Oncology (SIO) Annual Scientific Meeting, Washington, DC

March 4-9, 2023 Society of Interventional Radiology (SIR) Annual Meeting, Phoenix, AZ | Abstracts are due October 13.