March 25, 2021 - FUS-Enhanced Blood Test for Brain Tumors – and more news



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March 25, 2021

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Focused Ultrasound–Enhanced Blood Test for Brain Tumors: World-First Results Published
  • Liquid biopsy is a blood test used to diagnose and monitor treatment of brain tumors.
  • Nine patients with glioblastoma (GBM) underwent liquid biopsy before and after focused ultrasound treatment that disrupted the blood-brain barrier to enhance chemotherapy delivery.
  • This first-in-human study – recently published in Neuro-Oncology – found focused ultrasound enriched the amount of circulating brain tumor biomarkers in the peripheral blood.
  • The results suggest that focused ultrasound could reduce the need for invasive brain tumor biopsies and allow better monitoring of GBM treatment responses. 
Foundation News
Leading Authority on Brain Tumors Joins Foundation
  • Jason Sheehan, MD, PhD, Professor of Neurosurgery at the University of Virginia, has joined the Foundation as the Senior Advisor for Brain Tumor Research.
  • He will help define the Foundation’s strategy for brain tumor research, engage in Foundation-initiated research, and interface with medical societies.

Register Now for Two Webinars Featuring Foundation's Chief Scientific Officer REGISTER: CELEBRATING WOMEN IN BIO > 

Apply Now: Andrew J. Lockhart Postdoctoral Fellowship in Focused Ultrasound and Immuno-Oncology  
  • The Fellowship fosters early-stage investigators in the field of focused ultrasound in immuno-oncology.
  • The award will provide a one-year stipend of $75,000.
  • Interested parties have until May 31 to apply.
Research News
Focused Ultrasound for Opioid Use Disorder: First Patient Treated in New Trial
  • Researchers at West Virginia University have begun a first-in-the-world clinical trial investigating focused ultrasound to address opioid use disorder.
  • The trial aims to reduce patients’ substance cravings and addictive behaviors. 
  • COVID-19 has intensified the addiction crisis, and researchers hope to be able to offer patients a new treatment option.

Focused Ultrasound for Blood-Brain Barrier Opening in Patients with Parkinson’s Dementia
  • Up to 80% of Parkinson’s disease patients experience problems with attention span and decision-making tasks.
  • Scientists in Madrid tested the safety of using focused ultrasound plus microbubbles to open the blood-brain barrier in these patients.
  • Early evidence suggests this method could deliver therapeutics to prevent or reduce cognitive symptoms.

Focused Ultrasound Neuromodulation Reaches Deep Brain Structures
  • Researchers investigated whether low-intensity focused ultrasound (LIFU) could reach and alter deep brain structures.
  • These brain circuits are responsible for important cognitive, sensory, and motor functions.
  • Bold signal and perfusion changes were observed in the targeted regions, and the results were published in Scientific Reports.

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More Research News
New Radiology Research Shows Promise for Focused Ultrasound Treatment of Alzheimer’s | Huntington Herald-Dispatch
MRI-Guided Focused Ultrasound Ablation Shows Promising Early Outcomes in the Treatment of Prostate Cancer | Cancer Network
Reprogramming the Brain to Enable Regeneration | University of Toronto
TGH Begins Trial of New Device Created to Destroy Tumors without Surgery | 83 Degrees Media
SickKids-Led Research Receives $23.3 Million from the Canada Foundation for Innovation | SickKids
Leslie Dan Faculty of Pharmacy Develops Radiopharmaceutical to Support Innovative Clinical Trial | University of Toronto
Ultrasound Pulses Focused at Liver Help Treat Obesity in Mouse Models | New Atlas
Feinstein Institutes and GE Research Demonstrate Ultrasound Stimulation Reduces Obesity | Business Wire
Industry News
Two Upcoming Webinars will Focus on Impact of Profound Medical's Devices 
  • On April 1, Profound Medical will share how the TULSA-PRO system changed prostate care for one German clinic. 
  • The company also will host three physicians to highlight the flexibility of the Sonalleve system for pediatric benign and malignant tumors on May 12.

More Industry News
Management of Recurrent Prostate Cancer after Focal Therapy | Urology Times
Histosonics Tests Sonic Beam Therapy for Liver Tumors | BioWorld
Profound Medical Announces the Appointment of Cynthia Lavoie to its Board of Directors | Globe Newswire
Profound Medical Announces Fourth Quarter and Full Year 2020 Financial Results | Globe Newswire
Celebrating Women in Bio
  • Tuesday, March 30, 2021, at 12:00 pm Eastern
  • The Foundation's Chief Scientific Officer, Jessica Foley, PhD, joins others to discuss opportunities and challenges for women scientists and business leaders.
  • Hosted by CvilleBioHub

The Evolution of Prostate Care and Men's Health at the ALTA Klinik
  • Thursday, April 1, 2021, at 12:00 pm and 9:00 pm Eastern
  • Dr. Agron Lumiani will share how the TULSA-PRO system changed prostate care in his ALTA Klinik in Germany.
  • Hosted by Profound Medical

Pediatric Neurology Applications of High and Low-Intensity Frequency Ultrasound
  • Friday, April 2, 2021, at 12:00 pm Eastern
  • The presentation is the last of four virtual sessions in the 31st Annual Pediatric Neurology Update hosted by Children's National Hospital.
  • There is a $25 registration fee.

Focused Ultrasound at the Tipping Point
  • Thursday, April 8, 2021, at 12:00 pm Eastern
  • The Foundation’s Chief Scientific Officer, Jessica Foley, PhD, will discuss the state of focused ultrasound research and future applications.
  • Hosted by Virginia Bio

Recent Webinar Recordings
CNS Hot Topics & Expert Perspectives: Treatment of Refractory Obsessive-Compulsive Disorder | Hosted by the International Stereotactic Radiosurgery Society (ISRS) | The recording is available until June 2021. (2 hours 48 minutes)

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Upcoming Events
March 20-26, 2021 Society of Interventional Radiology (SIR) Annual Meeting | VIRTUAL MEETING

March 30, 2021 Celebrating Women in Bio | WEBINAR

April 1, 2021 The Evolution of Prostate Care and Men's Health at the ALTA Klinik  | WEBINAR

April 2, 2021 31st Annual Pediatric Neurology Update: Applications of High and Low-Intensity Frequency Ultrasound (HIFU/LIFU)  | WEBINAR

April 8, 2021 Focused Ultrasound at the Tipping Point: State of the Field and Future Applications  | WEBINAR

April 10-13, 2021 European Conference on Interventional Oncology (ECIO) 2021 | VIRTUAL MEETING

April 11-14, 2021 American Institute for Ultrasound in Medicine Annual Integrative Ultrasound Meeting 2021 | VIRTUAL MEETING

May 12, 2021 A Flexible MRgHITU Platform for Precise and Incision-free Ablative Therapies | WEBINAR

June 6-9, 2021 International Society for Therapeutic Ultrasound (ISTU) 2021Gyeongju, Korea 

June 8-10, 2021 180th Meeting of the Acoustical Society of America (ASA) | VIRTUAL MEETING 

June 10-12, 2021 Society for Neuro-Oncology (SNO) Pediatric Conference, Washington, DC

June 17-18, 2021 1st HIFUture Symposium, Lyon, France

September 25-29, 2021 Cardiovascular and Interventional Radiological Society of Europe (CIRSE) 2021, Lisbon, Portugal