The cover of the journal Theranostics recently featured research led by Nathan McDannold, PhD, in the Department of Radiology at Brigham and Women’s Hospital and Harvard Medical School in collaboration with several other departments.
In “Acoustic Feedback Enables Safe and Reliable Carboplatin Delivery Across the Blood-brain Barrier with a Clinical Focused Ultrasound System and Improves Survival in a Rat Glioma Model,” the team used the Exablate Neuro low-frequency clinical transcranial focused ultrasound system to safely, repeatedly, and reliably disrupt the blood-brain barrier (BBB) in a rat model of aggressive glioma. While the BBB was open, the team delivered a non-neurotoxic chemotherapy agent, carboplatin, to the brain in dosages that slowed tumor growth and significantly prolonged survival as compared to treatment with the drug alone.
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The 14th annual meeting of the European Association of Neuro-Oncology (EANO) was held in Lyon, France, September 19-22, 2019. More than 800 participants from over 50 countries convened with the goal to improve the treatment of patients with various neurological malignancies.