Key Points

  • Up to 80% of Parkinson’s disease patients experience problems with attention span and executive and decision-making tasks.
  • Scientists in Madrid tested the safety of using focused ultrasound plus microbubbles to open the blood-brain barrier (BBB) in these patients.
  • This early evidence suggests that BBB opening could be used to deliver neuroprotective therapeutics to prevent or reduce the cognitive symptoms.

Key Points

  • Researchers sought to determine whether low-intensity focused ultrasound (LIFU) could reach and alter the deepest structures of the brain.
  • These brain circuits are responsible for important cognitive, sensory, and motor functions, but other noninvasive neuromodulation techniques have failed to reach them.
  • When the researchers applied LIFU to healthy volunteers, they observed bold signal and perfusion changes in the targeted regions.
  • The team has published their results in Scientific Reports.

The Andrew J. Lockhart Postdoctoral Fellowship in Ultrasound and Immuno-Oncology was established in January 2021 through the generosity of the Lockhart family, who are longtime supporters of the Focused Ultrasound Foundation. This one-year fellowship will pair early-career focused ultrasound investigators with immunology laboratories and/or immuno-oncology investigators with focused ultrasound laboratories. The award will provide a one-year stipend of $75,000.

Key Points

  • The field of focused ultrasound for pediatrics celebrated two milestones in the past year: the Foundation designated its first pediatric Center of Excellence, and the FDA approved focused ultrasound therapy for the first pediatric condition.
  • Learn about the current clinical trials available for these young patients.
  • The Foundation hosted a Pediatric Benign Brain Tumor Workshop to discuss using focused ultrasound to treat these difficult tumors.
  • We established a Scientific Advisory Board of experts to create a roadmap forward for all pediatric applications.

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