The Journal of Gene Medicine has e-published ahead of print a preclinical study about a novel gene delivery method and a novel strategy for treating liver tumors. A team of Chinese researchers report succeeded in inhibiting liver tumor growth and improving survival time by combining high intensity focused ultrasound ablation with ultrasound-targeted microbubbles loaded with the herpes simplex virus thymidine kinase gene.

Entitled High-intensity focused ultrasound combined with herpes simplex virus thymidine kinase gene-loaded ultrasound-targeted microbubbles improved survival of rabbit with VX2 liver tumor, the study was conducted at the Second Affiliated Hospital of Chongqing Medical University in Chongqing, China.


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