Many publications on the use of FUS to open the BBB are now available, and new findings are continually being published. This brief, alphabetical bibliography includes some of the more recent review papers and those that provide a broader overview of this exciting field.

Science Mag graphicAlonso A. Ultrasound-induced blood-brain barrier opening for drug delivery. Front Neurol Neurosci 2015;36:106–15.

Aryal M, Arvanitis CD, Alexander PM, McDannold N. Ultrasound-mediated blood-brain barrier disruption for targeted drug delivery in the central nervous system. Adv Drug Deliv Rev 2014 Jun;72:94-109.

Burgess A, Shah K, Hough O, Hynynen K. Focused ultrasound-mediated drug delivery through the blood-brain barrier. Expert Rev Neurother 2015 May;15(5):477-91.

Burgess A, Hynynen K. Microbubble-Assisted Ultrasound for Drug Delivery in the Brain and Central Nervous System. Adv Exp Med Biol 2016;880:293-308.

Burgess A, Hynynen K. Drug Delivery Across the Blood-brain Barrier Using Focused Ultrasound. Expert Opin Drug Deliv 2014 May; 11(5):711–721.

Deng CX. Targeted drug delivery across the blood-brain barrier using ultrasound technique. Ther Deliv 2010;1(6):819–848.

Downs ME, Buch A, Sierra C, Karakatsani ME, Teichert T, Chen S, et al. Long-Term Safety of Repeated Blood-Brain Barrier Opening via Focused Ultrasound with Microbubbles in Non-Human Primates Performing a Cognitive Task. PLoS ONE 2015;10(5):e0125911.

Fan C-H, Ting C-Y, Chang Y-C, Wei K-C, Liu H-L, Yeh C-K. Drug-loaded bubbles with matched focused ultrasound excitation for concurrent blood-brain barrier opening and brain-tumor drug delivery. Acta Biomater 2015;15:89–101.

Meairs, S. Facilitation of Drug Transport across the Blood-Brain Barrier with Ultrasound and Microbubbles. Pharmaceutics 2015, 7, 275-293.

Park J, Zhang Y, Vykhodtseva N, Jolesz FA, McDannold NJ. The kinetics of blood-brain barrier permeability and targeted doxorubicin delivery into brain induced by focused ultrasound. J Control Release: Off J Control Release Soc. 2012;162(1):134–142.

Samiotaki G, Acosta C, Wang S, Konofagou EE. Enhanced delivery and bioactivity of the neurturin neurotrophic factor through focused ultrasound—mediated blood-brain barrier opening in vivo. J Cereb Blood Flow Metab 2015;35:611–22.

Tung Y-S, Vlachos F, Feshitan JA, Borden MA, Konofagou EE. The mechanism of interaction between focused ultrasound and microbubbles in blood-brain barrier opening in mice. J Acoust Soc Am 2011;130(5):3059–3067.



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