Research News

  • June 2015 Research Roundup

    Could a uterine fibroid numerical rating scale assist physicians with focused ultrasound patient selection? Is CT always needed when using focused ultrasound to treat the brain? Read these papers, along with two that review focused ultrasound treatment for glaucoma.

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  • Investigator Profile: Q&A with Elisa Konofagou, PhD

    Dr. Elisa Konofagou is Professor of Biomedical Engineering and Radiology at Columbia University and head of the Ultrasound Elasticity Imaging Laboratory (UEIL)there. Breaking through barriers, she is exploring alternative imaging techniques for focused ultrasound procedures, investigating neurological and cancer applications in preclinical studies, and working with her team to build medical devices in-house to meet their research needs.

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  • Foundation Scientists Build Collaboration in Korea

    Foundation scientists recently returned from a productive trip to Korea, where they made presentations and expanded our collaborative network. John Snell, PhD, Brain Program Technical Director and current and past Foundation fellows Dong-guk Paeng, PhD, and Jean-Francois Aubry, PhD spent a week speaking at two universities and two conferences. Dr. Paeng shared his country, national cuisine, and culture with the others.

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  • Investigator Profile: Q&A with Justin Hanes, PhD

    Justin Hanes, PhD, is the Lewis J. Ort Professor of Ophthalmology, with joint appointments in Biomedical Engineering, Chemical & Biomolecular Engineering, Environmental Health Sciences, Neurosurgery, Oncology, and Pharmacology & Molecular Sciences at Johns Hopkins University School of Medicine. He is also the Director of the Center for Nanomedicine, The Wilmer Eye Institute at JHU.

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  • Investigator Profile: Q&A with Rich Price, PhD

    Richard Price, PhD, is a Professor of Biomedical Engineering, Radiation & Radiation Oncology and Research Director of the UVA Focused Ultrasound Center. 

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  • UVA and Hopkins Collaborate to Use FUS to Deliver Nanoparticles into the Brain

    Biomedical engineers at the University of Virginia (UVA) and Johns Hopkins University (JHU) have developed a prolific collaboration that has generated several long-term, multi-million-dollar focused ultrasound research grants.

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  • Painful Bone Tumor Trial Begins at Children's National

    Children’s National Health System has become the first site in the US to use focused ultrasound to treat osteoid osteoma, a benign but painful bone tumor that commonly occurs in children and young adults.

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  • IGNITE Pursues Non-Invasive Pediatric Solutions

    On May 8th, the Image-Guided Non-Invasive Therapeutic Energy (IGNITE) Consortium met in Cincinnati to discuss using non-invasive therapies like focused ultrasound for treating pediatric diseases.

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  • Investigator Profile — Chandan Guha, MBBS, PhD

    At February’s Cancer Immunotherapy workshop, Chandan Guha, MBBS, PhD, presented his preclinical work using focused ultrasound (FUS) to create a “tumor vaccine.”

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  • Research Published on FUS Delivering Genes to the Spinal Cord

    Nature’s Gene Therapy journal has published pioneering work on the use of focused ultrasound to deliver genetic material across the blood-spinal cord barrier (BSCB).

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  • April 2015 Foundation Research Award Update

    The presence of imbedded gold nanoparticles (GNPs) can amplify tumor tissue’s sensitivity to radiation therapy and potentially alter the course of treatment for many different types of cancer. Can focused ultrasound induce hyperthermia to improve the imbedding process? In the final report from a 2013 High-Risk Track Foundation Research Award submitted by MD Anderson Cancer Center Principle Investigators Sunil Krishnan, MD, and Jason Stafford, PhD, the answer is “Yes.”

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  • Progress in Drug Delivery Models Presented at STM 2015

    The thermosensitive drug delivery session included four abstracts on the use of focused ultrasound to treat various forms of cancer and to study the potential applications in the pediatric population during the Society for Thermal Medicine’s (STM) 32nd Annual Meeting held April 14-17 in Orlando.

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  • ISTU 2015: Clinical Highlights, Aubry Named President

    Approximately 250 attendees gathered at the historic Dom church in Utrecht, The Netherlands for the International Society for Therapeutic Ultrasound's (ISTU) recent symposium. Presentations included updates from several ongoing clinical and technical studies. Jean-Francois Aubry, PhD, who spent more than a year as a Fellow at the Foundation, was chosen as the next President of ISTU.

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  • Letter to Editor on FUS for Alzheimer’s Published

    In response to last month’s groundbreaking preclinical research on focused ultrasound improving memory in Alzheimer’s published in Science Translational Medicine, Jessica Foley, PhD, the Foundation’s Chief Scientific Officer, and Steven T. DeKosky, MD, Chair of the Foundation’s Alzheimer’s Disease Steering Committee, co-published a Letter to the Editor.

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  • March 2015 Research Roundup

    Leading the list of exciting new publications, Scientific Reports published Drs. Yongan Chung and Seung-Schik Yoo’s successful use of focused ultrasound--induced neuromodulation in a human subject. Additional highlighted work includes a technical study on the development of a new approach to possibly treat pancreatic cancer, a collaborative and comprehensive review of histotripsy indications, and a review from China of 5,000 patients in eight different indications who were treated with ultrasound-guided focused ultrasound.

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  • Foundation Research Award Update: Chris Diederich

    “MR Directed Focal Hyperthermia for Pelvic Disease” by Chris J. Diederich, PhD, et al. from the University of California San Francisco.

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  • 1st Quarter 2015 Foundation Research Award

    One project was selected for a Foundation research award in the first quarter of 2015. Principal Investigator Cyril Lafon, PhD, Director of Research at the French Institute of Health and Medical Research (INSERM), and his team will study “Trans-Esophageal Cardiac Ablation Using High Intensity Focused Ultrasound: A New Minimally Invasive Therapy for Treating Arrhythmias.”

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  • Fibroid Treatment Presented at Interventional Radiology Meeting

    This year’s Society of Interventional Radiology’s (SIR) Annual Scientific Meeting in Atlanta included two focused ultrasound presentations from researchers at the University of California San Francisco on predicting treatment success and near field temperature monitoring when treating uterine fibroids.

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  • Sunnybrook Research Institute: Progress from Laboratory to Clinic

    In just a few years, the Sunnybrook Research Institute in Toronto has grown into a translational research powerhouse, helping to advance the field of focused ultrasound in both the laboratory and the clinic. The group is headed by pioneering physicist Kullervo Hynynen, PhD, who has been conducting research in the field for more than 30 years, has over 300 publications, and was instrumental in the development of the first clinical system for MR-guided focused ultrasound.

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  • New Pre-Clinical Research Further Validates Potential for Focused Ultrasound in Alzheimer's

    A pre-clinical study published this week in Science Translational Medicine suggests that focused ultrasound may hold a key to providing a non-invasive, non-pharmaceutical approach to treating Alzheimer’s disease.

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  • Study Suggests Focused Ultrasound May Help Unlock Alzheimer's

    New results published this week in Science Translational Medicine suggest that focused ultrasound might hold a key to providing a non-invasive, non-pharmaceutical therapy to treat Alzheimer’s disease.

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  • Focused Ultrasound Used to Heat Brain Tumors

    After battling breast cancer for 12 years, Cynthia received devasting news; the cancer had spread to her brain. That's when Cynthia and her family turned to a clinical trial investigating the use of focused ultrasound.

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  • February 2015 Research Roundup

    • A history and review in World Neurosurgery states that “as the quest for minimally invasive and noninvasive therapeutics continues to define the new neurosurgery, the focused ultrasound evolves to join the neurosurgical armamentarium.” Read the article.
    • Researchers at Columbia University used focused ultrasound to introduce neuroprotective and regenerative molecules across the blood-brain barrier. Read the article.

    • The Journal of Evidence Based Medicine includes a review on focused ultrasound for pancreatic cancer. Read the article.

    Ultrasound Guidance
    • Leading physicists review focused ultrasound-guided therapy under ultrasound, rather than MRI, guidance. Read the article.

    • A German medical review on uterine fibroid treatment includes focused ultrasound. Read the article.
    • Focused ultrasound is being used for several gynecologic indications in China. Read the article.

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  • In Memoriam: Floyd Dunn

    On January 24, we lost one of the giants of therapeutic ultrasound when Professor Floyd Dunn passed away at age 90.

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  • Researchers Tackle Brain Technical Issues

    As more than 30 experts from around the world gathered at the Brain Simulation Workshop, we sat down with a group of young researchers to discuss the work needed to broaden the areas of the brain that can be treated with focused ultrasound.

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  • Groups Collaborate To Assess Potential of FUS-Immunotherapy Combination

    On February 11th in New York, the Foundation partnered with the Cancer Research Institute to convene a one-day meeting of scientists and clinicians to discuss the current status of and future directions for focused ultrasound (FUS) research as it relates to cancer immunotherapy. 

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  • Workshop Creates Roadmap for Brain Simulation

    Thirty leading engineers, physicists, and clinicians from 17 organizations convened at the Brain Workshop on Treatment Envelope & Simulation in Charlottesville February 2-3. They gathered to discuss ways to create accurate computer simulations to assess expanding the treatable area of the brain (treatment envelope), to facilitate patient selection, and to predict and prevent unwanted secondary effects like skull heating.

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  • Study Explores Focused Ultrasound for Alzheimer's Disease

    New research suggests that focused ultrasound may hold answers to one of today’s more devastating diseases - Alzheimer’s

    In a preclinical study, researchers at Sunnybrook Research Institute in Toronto were able to reverse some Alzheimer’s disease symptoms in mice. The study, funded by the National Institute of Health, used focused ultrasound to temporarily open the blood-brain barrier. Once open, microbubbles can more effectively pass through to the diseased tissue in the brain. The treatment led to improvements in cognition and spatial learning, and did not cause tissue damage or negative behavioral changes.

    Though early-stage, this research could open the doors to more studies and greater possibilities for this innovative technology.

    Read the NIBIB Press Release.

    Read media coverage from DOTmed and Gizmag.

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  • Important Meetings for Your 2015 Calendar

    As we begin the new year, we encourage you to mark your calendars for these important meetings.

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  • Nanodroplets Enhance Focused Ultrasound Ablation

    Last August, we profiled external award recipient Paul Dayton, PhD and the nanodroplet research being conducted by his team at the Joint Department of Biomedical Engineering at the University of North Carolina Chapel Hill and North Carolina State University, Raleigh.

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  • December 2014 Research Roundup

    Does focused ultrasound plus chemotherapy and radiation have a better survival rate, efficacy, and clinical outcome than other treatments for pancreatic cancer? Is focused ultrasound a safe and noninvasive treatment for local unresectable recurrence of osteosarcoma? What are the long-term results for uterine fibroid patients 5 years after focused ultrasound treatment? Can focused ultrasound be used for salvage therapy after brachytherapy in patients with prostate cancer? These questions were posed in recently published journal articles.

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  • 2014 4th Quarter Research Awards

    The Foundation has funded five new External Research Award projects for the 4th quarter of 2014. Three preclinical and two clinical studies will evaluate the use of focused ultrasound for:

    • Papillary thyroid cancer (University of Virginia)
    • Intranasal DNA nanoparticle delivery (Northeastern University in collaboration with Brigham and Women’s Hospital/Harvard University)
    • Osteoarthritis joint pain (Rizzoli Institute in Italy)
    • Neuromodulation and functional imaging (Vanderbilt University)
    • Multiple sclerosis (University of Washington)

    David Shonka, MD, University of Virginia clinical project: “A Pilot Study to Evaluate the Feasibility and Safety of High Intensity Focused Ultrasound for Treatment of Papillary Thyroid Cancer.”

    The incidence of differentiated thyroid cancers, comprised primarily of PTC, has more than doubled over the last twenty years, due in part to increased detection of small (≤2cm) tumors. Total thyroidectomy remains the recommended treatment for these malignancies, but poses significant risks and lifelong hormone replacement for patients. A non-surgical alternative is needed for this rapidly growing patient population. The purpose of this two-stage study is to evaluate the feasibility and safety of HIFU for treating PTC.

    Methodology: In Stage 1, HIFU ablation will be performed on biopsy-proven PTC thyroid nodules 9 weeks prior to thyroidectomy. Feasibility of HIFU is measured as completion of proposed therapy. Safety is evaluated by incidence of treatment-related adverse events. Efficacy is judged by serial diagnostic ultrasound (DUS) imaging performed every 3 weeks following HIFU and confirmed by histological exam of the target nodule following surgery. In Stage 2, subjects with small PTCs (≤2 cm) will be treated with HIFU ablation alone. Subjects will be followed for 12 months to assess residual disease and/or disease recurrence/progression. If a residual nodule of viable PTC persists after FUS treatment, or if patients exhibit evidence of progression, patients will have the option to undergo total thyroidectomy as a salvage procedure.

    Barbara Waszczak, PhD, Northeastern University in collaboration with Nathan McDannold at Brigham and Women’s Hospital, preclinical project: “Focused Ultrasound for Increased Delivery of Intranasal DNA Nanoparticles to Rat Brain.”

    We will investigate whether focused ultrasound (FUS) can increase delivery to the brain of a nonviral gene vector given by the intranasal route of administration. Aim 1 will examine different FUS treatment conditions to determine if FUS can increase total plasmid DNA nanoparticle (NP) delivery and transgene expression in the sonicated regions, the rat substantia nigra and striatum, two brain areas involved in Parkinson's Disease (PD). Aim 2 will test whether FUS improves tissue penetration and alters cellular transfection patterns in the sonicated regions following intranasal doses of DNA NPs. If successful, FUS may enable agents with poor capabilities of crossing the blood-brain barrier (BBB), e.g. neurotrophic factors, viral and non-viral vectors encoding them, to become disease-altering therapies by a non-invasive route of administration.

    Alberto Bazzocchi, MD, Rizzoli Institute (Italy), clinical project: “Magnetic Resonance guided Focused Ultrasound Surgery: a pilot study in the treatment of pain caused by osteoarthritis - hand and hip, challenging joints.”

    Pain caused by osteoarthritis is a matter of huge impact, in terms of quality of life, social, and economic burdens. The aging of the population is even going to augment the problem. The hand is the most affected site in the upper limb, and the trapeziometacarpal joint is crucial for the prevalence of the disease and for determining significant limitations of function when involved. In the lower limb, the hip and the knee share the leading position in the clinical scenario, with the former being historically the most frequently submitted to joint replacement. At any site, the vast majority of joint replacement surgery procedures are performed because of pain. Magnetic Resonance guided Focused Ultrasound Surgery (MRgFUS) has recently demonstrated a great potential in fighting pain caused by different medical conditions, including osteoarthritis. The aim of the work is to study the feasibility, the safety, and the potential efficacy of MRgFUS in treating pain from osteoarthritis in two "hot" spots: the hip and the trapeziometacarpal joint.

    Charles Caskey, PhD, Vanderbilt University, preclinical project: “Noninvasive targeted neuromodulation and functional imaging in behaving macaques.”

    All presently available neural stimulation methods are either invasive or can only be moderately localized, and a neurostimulation method that could overcome these limitations would be invaluable for the mapping of brain circuits, disease diagnosis in the brain, neurosurgery and therapy. Neural stimulation with magnetic resonance guided focused ultrasound (MRgFUS) is a promising technology that can noninvasively excite or inhibit neural activity in well-defined discrete volumes of the brain, subsequently enabling investigation of brain circuits with magnetic resonance imaging (MRI). In this study, we seek to explore ultrasonic neuromodulation in the frontal eye field of a macaque monkey, while measuring the effects of neuromodulation via event-related potentials, behavioral responses, and blood oxygen level dependent functional MRI.

    Pierre Mourad, PhD, University of Washington, preclinical project: “Modulated focused ultrasound for treatment of demyelinating axons in multiple sclerosis lesions - pilot animal studies.”

    Multiple sclerosis is a debilitating disease whose symptoms arise from demyelination of axons within brain tissue with an attendant loss of central and peripheral function. We, among others, have shown that transcranial delivery of pulsed focused ultrasound (pFU) can non-destructively activate central neural circuits. Others have shown enhanced myelin remodeling of axons activated by laser light in an optogenetic mouse model. We hypothesize that pFU activation of axons within MS lesions in a rodent model will decrease their demyelination and increase their re-myelination. If successful, this non-invasive therapy may lead to rapid advancements in the treatment of MS and other demyelinating neurological disorders.

    See the complete database of funded projects.

    Researchers who are interested in applying for an external research award should contact Matt Eames, PhD, Director of Extramural Research, (434) 326-9834 or

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  • Focused Ultrasound at RSNA 2014

    The Radiological Society of North America (RSNA) again featured significant focused ultrasound research at its 2014 annual meeting. A total of 18 abstracts covered a range of different diseases, including musculoskeletal tumors, neurological and oncological applications, bone metastases, pancreatic cancer, prostate cancer, and uterine fibroids. In addition to the papers and posters, one entire session was dedicated to focused ultrasound, and the technology was also included in the “Hot Topics” session.

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  • Investigator Profile: Jin-woo Chang, MD, PhD

    Neurosurgeon Jin-woo Chang, MD, PhD, is pioneering focused ultrasound research for neurological and psychiatric disorders. Currently directing the Korean site for the ExAblate Essential Tremor pivotal trial, he also performed the world’s first focused ultrasound pallidotomy in a patient with Parkinson’s disease as part of the global Parkinson’s Dyskinesia study. In addition to movement disorders, Dr. Chang is breaking new ground by conducting the world’s first clinical trials using focused ultrasound to treat psychiatric disorders like obsessive-compulsive disorder (OCD) and depression.

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  • Dr. Dong-guk Paeng Joins Foundation as Merkin Fellow

    The Richard Merkin Visiting Fellowship Program will begin on January 1, 2015 with the arrival of Dong-guk Paeng, PhD from Jeju National University in Korea.

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  • November 2014 - Research Roundup

    Three interesting papers have recently been published about the use of focused ultrasound (FUS) in the brain. Could 3D MR thermometry play a key role in understanding and expanding the FUS treatment envelope? Does skull thickness matter? What parameters are needed to begin using low-frequency FUS in the brain?

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  • Focused Ultrasound Research Broadly Recognized at the 10th Interventional MRI Symposium in Germany

    A research group based at Kobe University in Japan received the magna cum laude poster award at the 10th Interventional MRI Symposium held last month in Leipzig, Germany. Their winning project featured work in analyzing liver deformation to obtain MR images prior to focused ultrasound (FUS) treatment. Of the 63 posters accepted at this technically-oriented meeting, seven included FUS.

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  • FDA Panel Calls for More Data on Sonacare’s Prostate Treatment

    sonacareA US Food and Drug Administration advisory panel voted on October 1 not to recommend approval at this time for Sonacare Medical's Sonablate 450 focused ultrasound system for the treatment of recurrent prostate cancer.

    The panel felt the interim data of 100 patients in a 200-patient trial was insufficient to recommend approval, and they advised the company to continue their ongoing study. The experts voted that the risk of the treatment was too high for the limited efficacy demonstrated, that there is not reasonable assurance that the system is effective for this population, and that the benefits do not outweigh the risks based on the evidence presented. Sonablate did receive some positive votes for safety and efficacy, but not enough to meet the level of evidence needed to recommend approval in the United States.

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  • September 2014 Research Roundup

    Could focused ultrasound be a safer and more effective treatment for hypersplenism (a common disease where the spleen is overactive and removes blood cells too early and too quickly) than current conventional treatments? When it comes to biomedical engineering, focused ultrasound transducers can have complicated geometric patterns – is 3D printing the answer to their fabrication?

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  • Brigham Researchers Demonstrate Real-time Microbubble Monitoring for Transcranial Focused Ultrasound

    Potential Boon to Future Regulatory Approval of Non-thermal Brain Applications Also Wins Prestigious Research Prize

    The Roberts Prize for the best article published in Physics in Medicine and Biology was recently awarded to Costas Arvanitis, Margaret Livingstone, and Nathan McDannold from Brigham and Women's Hospital and Harvard Medical School in Boston for their article “Combined Ultrasound and MR Imaging to Guide Focused Ultrasound Therapies in the Brain.”More than a way to monitor focused ultrasound (FUS), such as FUS-induced blood-brain barrier disruption, their work could likely be a key to demonstrating the level of safety required by regulatory agencies who will review focused ultrasound treatment of brain conditions.

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  • University of Maryland to Become Major Focused Ultrasound Neuroscience Research Center

    Patients from Across the Country Participating in Essential Tremor Trial

    The University of Maryland’s pioneering Neuroscience Center in Baltimore is poised to become a leading hub for focused ultrasound research. They recently began treating patients in the pivotal trial to treat essential tremor using InSightec’s Exablate Neuro system.

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  • Swedish's Focused Ultrasound Brain Program Excels

    Institute now studying Essential Tremor, Parkinson's, and Tumors

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  • 2014 Summer Interns Contribute to Foundation Research

    In its third year, the Foundation’s summer internship program welcomed a record 12 students to collaborate with the Foundation staff. With so many hands on deck, many teamed up to tackle more complicated projects.

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  • August 2014 Research Roundup

    Recent focused ultrasound research covers a variety of applications. In oncology, two interesting studies looked at pancreatic cancer (safety and a comprehensive case review), and one discovered improved outcomes for localized prostate cancer. Cavitation-induced thrombolysis work is gaining ground, and another group provides cost-effectiveness data for uterine fibroid ablation.

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  • Nanodroplets May Significantly Reduce Focused Ultrasound Procedure Times

    North Carolina scientist Paul Dayton, PhD is in the final stages of a Foundation-funded study on the use of nanodroplets to improve the efficiency of focused ultrasound ablation.

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  • North American first in children: SickKids doctors destroy bone tumour using incisionless surgery

    The following release was issued by The Hospital for Sick Children (SickKids) on August 6, 2014. View the release in their press room. 

    TORONTO – A patient at The Hospital for Sick Children (SickKids) is the first child in North America to have undergone a specialized procedure that uses ultrasound and magnetic resonance imaging (MRI) to destroy a tumour in his leg without piercing the skin. Doctors used an MRI to guide high-intensity ultrasound waves to destroy a benign bone tumour called osteoid osteoma. The lesion had caused 16-year-old Jack Campanile excruciating pain for a year prior to the July 17 procedure. By the time he went to bed that night, the athletic teen experienced complete pain relief.

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  • Richard Merkin Visiting Fellowship in Focused Ultrasound

    The receipt of a significant gift from Dr. Richard Merkin has allowed the Foundation to create a unique fellowship opportunity for international researchers. Applications are now being accepted. For information on the application process, contact Matt Eames, PhD, Director of Extramural Research, .

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  • Preclinical Research Demonstrates Potential for Treating Epilepsy

    Results of preclinical studies conducted by the Foundation in collaboration with researchers at the University of Virginia and the Swedish Neuroscience Institute demonstrate that it may be feasible to treat certain types of epilepsy noninvasively with focused ultrasound (FUS). Investigators assessed the ability of FUS to reach and ablate the targets for mesial temporal lobe epilepsy and hypothalamic hamartoma utilizing cadavers and skulls filled with gel to mimic the brain. Further technical development is needed to reduce treatment time and the potential for skull heating.

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  • Research Roundup

    Important advances in the field of FUS have been plentiful this month—so much so that we could not pick one or two to feature. Instead, we include a roundup of recently published research on these topics:

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  • 2nd Quarter Research Awards: Four New Studies Funded

    The Foundation’s External Awards Program is pleased to announce that it has funded four new projects for the 2nd quarter of 2014. The topics are varied across several indications and include:

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  • Workshop Participants Create Neuromodulation Roadmap, Set Sights on Clinical Use

    A group of 24 researchers from 14 organizations met March 3-4 in Charlottesville to inventory the current state of the field, identify important applications, and chart a course for the first clinical use of FUS–induced neuromodulation. Participants represented academia, industry, government, and the Foundation.

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  • UCLA Researchers Investigate the Use of Neuromodulation to Treat Epilepsy

    Can neuromodulation reduce the excitability of neurons and therefore reduce seizures in epilepsy patients? That is the question that scientists at the University of California Los Angeles (UCLA) Semel Institute are asking.

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  • Worldwide Neuromodulation Research

    While UCLA is starting a clinical trial with FUS-induced neuromodulation, the field is growing, with at least 16 centers around the world active in laboratory research. These investigators are advancing the field on several fronts -- from clinical targeting to neurodiagnostics to treating pain and psychiatric disorders.

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  • Clinical Research Prize Encourages Progress

    The Focused Ultrasound Foundation will award a clinical neuromodulation research prize to the first investigator or team of investigators to elicit transient sensory symptoms or tremor suppression using non-thermal FUS neuromodulation during a patient treatment.

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  • New Scientist Highlights Blood Brain Barrier Research

    New Scientist, an international science magazine based in London, has featured a groundbreaking new study that could treat brain tumors using a combination of focused ultrasound and drug therapy. This story builds on the publication's previous coverage of focused ultrasound technology. 

    Kullervo Hynynen, a medical physicist at Sunnybrook Research Institute in Toronto, Canada, will begin a study to investigate the use of focused ultrasound to reversibily open the blood brain barrier, – the protective layer around blood vessels that shields our brain against outside threats. The study hopes that once the barrier is open, microbubbles filled with chemotherapy agents will be able to enter and treat brain tumors. 

    If successful, the team thinks that this procedure might also one day be used to treat Alzheimer's disease. 

    Read the full story. 

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  • UVA and Johns Hopkins Partner to Improve Brain Cancer Treatment

    Richard Price, University of Virginia biomedical engineering professor, and his colleagues at Johns Hopkins University are working together to open the blood-brain barrier and allow drug-bearing nanoparticles into the brain tissue. Their goal is to provide a new treatment for gliobastomas, the most common form of brain cancer.

    Price has developed a technique to breach the blood-brain barrier using microbubbles. By applying low-frequency ultrasound, one can cause the bubbles to oscillate, disrupting the blood-brain barrier. However, this is only the first challenge in treating gliobastomas.

    Brain cells are tightly packed, hindering therapeutic agents from diffusing through the brain. Here, researchers at Johns Hopkins stepped in, developing a nanoparticle coated in polyethylene glycol, enabling it to disperse freely.

    “We joined forces with John Hopkins because we each had a technology that addresses one of the two big physical barriers to drug delivery in the brain,” Price said. “We decided to put the two technologies together and see if that combination can actually produce efficacy.”

    Learn more about what these breakthroughs might mean for brain cancer treatment. 
    Read the full story as it appeared in UVAToday and InTheCapital.

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  • Vanderbilt’s Grissom Receives External Research Award To Improve Brain Temperature Imaging

    Will Grissom, PhD, from the Vanderbilt University School of Engineering has been awarded the first External Research Award of 2014 for his project titled “MR Temperature Imaging Toolbox for Focused Ultrasound Neurosurgery.” This project aims to develop brain temperature imaging sequences and processing algorithms that directly address the current shortcomings of MR thermometry at each stage of therapy.

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  • Program to Enable Focused Ultrasound to Treat a Moving Internal Organ Begins in Europe

    A European collaborative group has begun a translational research project to develop a clinical focused ultrasound system that would enable the treatment of a moving internal organ, such as the liver. The TRANS-FUSIMO (Clinical Translation of the Focused Ultrasound in Moving Objects) projectbuilds on an earlier collaboration (FUSIMO) between 11 European countries that created simulation software.

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  • Washington-Russian Collaboration Sends Shock Waves Through Focused Ultrasound

    An alternative method of tissue fractionation--boiling histotripsy--has been developed in a unique collaboration between and the University of Washington (UW) in Seattle and Moscow State University (MSU) in Russia. Drs. Vera A. Khokhlova, Lawrence A. Crum, and the growing UW/MSU teams have developed the method that uses longer (millisecond instead of microsecond) duration focused ultrasound pulses to generate a millimeter-sized boiling bubble (instead of a cavitation cloud) through tissue heating by shocks. Two papers that detailed their groundbreaking work were published in Ultrasound in Medicine and Biology and the Journal of the Acoustical Society of America.

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  • Focused Ultrasound Featured at European Congress of Radiology

    Radiologists from around the world gathered in Vienna this month for the 2014 European Congress of Radiology. Dr. Wadyslaw Gedroyc chaired a special focus session called “Treatment with MR-Guided Focused Ultrasound.” The session included a technology overview, a description of the technique, an update on treatment for uterine fibroids and adenomyosis, and an introduction to applications for transcranial ultrasound. A panel discussion entitled, “How can this technology be spread more widely?” rounded out the 90-minute program.

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  • Workshop Identifies Multiple Opportunities for Neuromodulation

    The Focused Ultrasound Foundation organized and hosted a workshop on March 3-4 in Charlottesville, Virginia, to discuss the state of the art, current challenges, and future research directions for using focused ultrasound to induce neuromodulation – the stimulation or blocking of neuronal activity in targeted areas of the brain.

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  • Meeting Highlights FUS as Potential Key Treatment of 21st Century

    Speakers at the European Congress of Radiology (ECR) Annual Meeting in Vienna, Austria, lauded the potential for Focused Ultrasound to be one of the most important treatment options on the horizon. reported on the conference, speaking with leaders in the focused ultrasound field about the key applications discussed.

    Uterine fibroids remains the most widely approved application of focused ultrasound, with the potential to help countless women. Discussion centered on ideas to overcome the slow adoption rates to date.

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  • Foundation-authored JTU Article Highlighted

    7th Space, an online portal covering news and headlines, has featured an article published in the Journal of Therapeutic Ultrasound (JTU). The JTU is the official publication of the International Society for Therapeutic Ultrasound and the Focused Ultrasound Foundation, which was recently chosed to be indexed on PubMed

    The article, authored largely by scientists and researchers at the Foundation, offers a snapshot of the field of focused ultrasound and its progress in the past decade.

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  • Foundation Publishes Global Report on Focused Ultrasound – A Resource for all Stakeholders

    The Focused Ultrasound Foundation has published its January 2014 Focused Ultrasound Global Perspective report, a comprehensive overview of the state of the technology, including facts and figures on approved indications, manufacturers, research centers, and treatment sites. This report will serve as a trusted resource for academia, government, industry, and investors, enabling them to monitor progress in the field and guide decision making.

    The report is now available on our website. An update will be produced every six months, identifying significant research and commercialization trends for the technology.

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  • Parkinson's Dyskinesia Study Begins

    A major milestone in the evolution of the field of focused ultrasound has been achieved. The first treatment in a 20-patient pilot study assessing the feasibility, safety, and preliminary efficacy of MR-guided focused ultrasound for dyskinesia in Parkinson's disease was successfully performed in Korea. This groundbreaking study is being funded in partnership with the Michael J. Fox Foundation.

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  • Gail ter Haar Draws a Crowd at FDA to Discuss FUS Quality Assurance and Standardization

    Focused ultrasound physics pioneer Professor Gail ter Haar, head of the Foundation’s Center of Excellence at the Institute of Cancer Research (ICR) in London, traveled with Foundation staff to Washington to deliver a presentation to the U.S. Food and Drug Administration (FDA) on her team’s work in quality assurance and standardization of high intensity focused ultrasound.

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  • Nature Neuroscience: Focused Ultrasound Enhances the Brain’s Sensory Perception

    As reported in the current issue of Nature Neuroscience, scientists on Dr. William J. Tyler’s research team at Virginia Tech were interested in using focused ultrasound to noninvasively modify human brain function. They targeted sensory areas of the brain and were surprised by their findings: low-intensity focused ultrasound significantly improved function by decreasing impulses to the median nerve in the arm thereby enhancing the patients’ ability to discriminate between different kinds of stimulation. Secondly, they were impressed that the focused ultrasound could target smaller, more specific areas in the brain as compared to other neuromodulation technologies.

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  • Wladyslaw Gedroyc Named Editor of the Journal of Therapeutic Ultrasound, Which Is Now Indexed on PubMed

    Focused ultrasound pioneer Dr. Wladyslaw Gedroyc has been named Clinical Editor-in-Chief of the Journal of Therapeutic Ultrasound(JTU), replacing start-up editor Dr. Arik Hananel.

    A consultant radiologist, Dr. Gedroyc is recognized worldwide as a pioneer in the development of noninvasive patient treatments using MR-guided focused ultrasound. Much of Dr. Gedroyc's ground-breaking work involved the treatment of uterine fibroids, pancreatic tumors, and liver tumors. He is currently investigating a focused ultrasound application to alleviate the severe back pain associated with facet joint disease.

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  • Focused Ultrasound for Parkinson's Disease Featured in Practical Neurology

    Focused ultrasound treatment for Parkinson's disease was featured as the cover story in the December issue of Practical Neurology.

    The article consisted of a Q&A with Dr. Binit B. Shah, MD, Assistant Professor, Neurology, Parkinson's Disease and Movement Disorders Division at University of Virginia.

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  • Focused Ultrasound Breast Research - December 2013 Update

    Additional research is being conducted around the world on breast cancer and breast fibroadenoma. For example, collaboration between Philips and Utrecht University Medical Center in the Netherlands is using an innovative system that has been designed specifically to treat breast tissue.

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  • Focused Ultrasound Featured at RSNA 2013

    Focused ultrasound research presentations made an impressive showing at this year’s RSNA annual meeting. A remarkable 27 sessions featured research on focused ultrasound ablation and/or drug delivery to treat many different diseases, including breast cancer, bone metastases, pancreatic cancer, prostate cancer, melanoma, uterine fibroids, and osteoid osteoma.

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  • Fourth Quarter Research Awards

    The Foundation’s External Research Awards Program has approved two new proposals for funding. One project is from the high-risk track, and the other is from the clinical indication track.

    The high-risk project is led by Zhen Xu, Ph.D., from the University of Michigan and will study the use of the mechanical effects of focused ultrasound to break up the blood clots that cause deep vein thrombosis. The clinical indication project is a pilot study in pediatric osteoid osteoma led by Michael Temple, M.D., at SickKids Hospital in Toronto.

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  • Promising Results in FUS Breast Cancer Study

    Results of a study presented today at the annual meeting of the Radiological Society of North America (RSNA) suggest MR-guided focused ultrasound (MRgFUS) may offer a safe, noninvasive treatment option for breast cancer.

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  • FUSF Brain Workshop: White Paper Available Online

    Experts who gathered at the June Brain Workshop were successful in identifying major opportunities and challenges for expanding the area in the brain that can be treated with focused ultrasound. Event details, including issues discussed and long-term projects, were reported in ourJuly newsletter.

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  • American Society For Radiation Oncology: 2013 Annual Meeting Highlights

    The Annual Meeting of the American Society for Radiation Oncology (ASTRO) was held in Atlanta on September 22-25, 2013. This meeting is the largest assembly of radiation oncology physicians and researchers in the world. Focused ultrasound has a growing and important role in clinical research in radiation oncology, and highlights included:

    1. J. E. Meyer from the Fox Chase Cancer Center presented their work on the pain palliation of bone metastases using focused ultrasound. Their retrospective analysis showed breast cancer metastases as having the best response rate (87%), which may impact future patient selection and treatment decisions.

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  • Experts Share Latest Advances at Rome Symposium

    More than 200 clinicians and scientists from Europe and across the globe gathered in Rome this month for the Focused Ultrasound Therapy - 2nd European Symposium, which was supported by the Foundation.

    “The symposium more than met our goals of sharing knowledge and stimulating new ideas,” said symposium co-chair Alessandro Napoli, MD, PhD, of Sapienza University of Rome. “The meeting helped to establish and consolidate relations, foster discussion of research approaches, and fuel advances in the field.”

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  • University of Utah Awarded $2.5M from NCI to Develop Treatment for Breast Cancer

    The National Cancer Institute has awarded Dennis Parker, PhD, and his team of researchers at theUtah Center for Advanced Imaging Research (part of the University of Utah School of Medicine) funding to further their work using focused ultrasound to treat breast cancer. After completing successful initial studies funded by the Focused Ultrasound Foundation, the Utah group was able to secure this prestigious R01 award to continue this promising work.

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  • First Patient Treated in Essential Tremor Pivotal Trial

    The first essential tremor patient in the pivotal trial for the ExAblate Neuro Focused Ultrasound System has been treated at Stanford, and the study is starting at the University of Virginia, Swedish Neuroscience Institute in Seattle, and Yonsei University Medical Center in Seoul, Korea.

    The trial is a multicenter, double-blinded, randomized study to evaluate the efficacy and safety of treatment using the ExAblate Neuro in medication-refractory essential tremor patients. The study builds upon promising pilot studies funded by the Focused Ultrasound Foundation that demonstrated the preliminary safety and effectiveness of FUS in treating target areas deep inside the brain. These studies were published in the New England Journal of Medicineand The Lancet Neurology.

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  • UVA Symposium Spurs Collaboration

    On September 4, more than 100 researchers, clinicians, and students from 14 departments attended the UVA Focused Ultrasound Center Evening Symposium.

    Presentations from experts covered a wide range of topics, including developments in MRI technology for focused ultrasound (FUS) applications, FUS-mediated drug delivery, and clinical and pre-clinical brain studies. The symposium also highlighted novel applications, such as exploring the use of FUS to aid traditional immunotherapy and treat osteoarthritic pain (see related story in our September 2013 Newsletter). This work showcases not only the versatility of the technology, but the breadth of indications on the horizon in FUS research.

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  • Merkin Fellowship Position Open

    The Foundation is now seeking applicants for the Richard Merkin Visiting Fellowship in Focused Ultrasound, created by Richard Merkin, MD, to foster collaboration between the Foundation and other institutions .

    The Fellowship in Focused Ultrasound is open to any mid-career or senior scientist or clinician from industry or academia around the world to work with the technical and scientific team at the Focused Ultrasound Foundation in Charlottesville, Virginia for about 12 months. The position will foster collaboration between the Foundation, the Fellow's home institution, and other institutions and will be paid through an annualized stipend of $150,000.

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  • Experts Discuss Research Direction at Blood-Brain Barrier Workshop

    The Focused Ultrasound Foundation and the Kinetics Foundation organized a workshop in September to discuss the state of the technology, current challenges, and future research directions for using focused ultrasound to reversibly open the blood-brain barrier to allow the delivery of drugs directly to the brain for treatment of cancer, Parkinson’s disease, Alzheimer’s disease, and other central nervous system disorders.

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  • Pioneer in Focused Ultrasound Cancer Treatment Named Honorary President for 2014 Symposium

    Feng Wu, MD, PhD, has been selected as Honorary President of the 4th International Symposium on Current and Future Applications of Focused Ultrasound to be held October 12-16, 2014 in Bethesda, Maryland.

    Wu has been a steadfast champion of focused ultrasound for more than 25 years. To date, his teams in China have treated more than 50,000 tumor patients, the largest population of focused ultrasound-treated patients in the world. Now living in England, Wu is a Focused Ultrasound Consultant and Senior Clinical Scientist at Oxford University. He is a leading researcher in the field, having published more than 200 papers. In 2013, he was awarded the International Society for Therapeutic Ultrasound’s William and Francis Fry Award for his outstanding contributions to the field.

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  • FUSF Establishes Center of Excellence in London

    Focused Ultrasound Foundation, Royal Philips, The Institute of Cancer Research, and The Royal Marsden collaborate in centre to accelerate progress and establish global standards for focused ultrasound treatment  ̶  enhancing patient care around the world

    LONDON – September 5, 2013 – The Focused Ultrasound Foundation and Philips have entered into an innovative public-private collaboration with The Institute of Cancer Research, London, and The Royal Marsden NHS Foundation Trust. The partnership will create a focal point for ultrasound therapy research at The Institute of Cancer Research (ICR) and The Royal Marsden in London under the international Focused Ultrasound Foundation Centers of Excellence Program.

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  • TED Talks - Focused Ultrasound for Brain Lesions




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  • ISTU Meeting Gave Added Emphasis to Clinical Studies

    Held in Shanghai, China from May 12-15, the 2013 meeting of the International Society of Therapeutic Ultrasound (ISTU) drew about 200 attendees and devoted an entire day to clinical presentations, indicating the society’s increasing emphasis on patient applications of therapeutic ultrasound.

    Feng Wu, MD, PhD received the 2013 Fry Award, which is given annually to an individual who has made outstanding contributions to therapeutic ultrasound. Wu is a HIFU Consultant and Senior Clinical Scientist at Oxford University in the United Kingdom.

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  • Announcing Our 2013 Research Award Recipient – Craig Meyer, PhD

    Craig H. Meyer, PhD has received a $100,000 Research Award from the Focused Ultrasound Foundation to develop a new real-time method for performing three-dimensional MR temperature mapping, a technique that could have a major impact on the safety, efficacy and procedural efficiency of focused ultrasound treatments.

    “MR temperature mapping is an integral element of MR-guided focused ultrasound surgery. However, acquisition of the MR images required for calculating a temperature map is time consuming. At present, it is not possible using conventional non-accelerated MR techniques to acquire and reconstruct 3D temperature maps in real time,” explains Meyer, an associate professor of Biomedical Engineering and Radiology at the University of Virginia.

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  • Michael J Fox Foundation Awards Grant for Parkinson’s Study

    The Focused Ultrasound Foundation was recently awarded a $600,000 grant by The Michael J Fox Foundation for Parkinson’s Research to help fund a pilot study of focused ultrasound for the treatment of dyskinesia in Parkinson’s disease.  The study will investigate the feasibility, safety and preliminary effectiveness of focused ultrasound as a non-invasive method to destroy a small volume of targeted tissue in the brain to improve motor symptoms and reduce the involuntary movements (dyskinesia) faced by Parkinson’s patients.

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  • Study Reports Significant Bone Mets Pain Relief Using Focused Ultrasound

    A high-dose of ultrasound targeted to painful bone metastases appears to quickly bring patients relief, and with largely tolerable side effects, according to new research presented by Fox Chase Cancer Center scientists at the 49th Annual Meeting of the American Society of Clinical Oncology on Monday, June 3.

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  • Researchers File Patent for FUS Method That Reduces Cardiac Impairment After Heart Attack

    Researchers from the Bonn University Hospital in Germany have filed a patent application for a focused ultrasound method that reduces impairment of cardiac function after an acute heart attack. In the method, microbubbles are injected into the bloodstream following a heart attack. When the bubbles reach the heart, stimulation with focused ultrasound causes them to oscillate and ameliorate the muscle damage that normally occurs after cardiac arrest.

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  • Canadian Study Assessing Thermal Ultrasound Treatment for Prostate Cancer

    Patients with localized prostate cancer are receiving treatment in a new clinical study assessing the safety of a transurethral ultrasound ablation system developed by Toronto-based Profound Medical Inc. The system, which uses a specially designed wand to deliver thermal ablative therapy, operates under MR guidance. It works on a variety of MRI platforms, can be moved from scanner to scanner and treats the whole prostate gland in one session.

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  • Seattle Center To Be a Major Force in Focused Ultrasound Brain Studies

    First patient trial at Swedish Medical Center will be for essential tremor

    One of the most prestigious neuroscience centers in the world is gearing up to become a major clinical force in MR-guided focused ultrasound brain research. Swedish Neuroscience Institute (SNI) at the Cherry Hill campus of Swedish Medical Center in Seattle, Washington, USA will soon treat patients with essential tremor as part of  an upcoming Phase III multicenter randomized trial and is considering studies for epilepsy, Parkinsonian tremor, metastatic tumors and intracerebral hemorrhage.

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  • Multi-center Pivotal Trial Will Be the Next Step in Evaluating Focused Ultrasound as Essential Tremor Treatment

    The encouraging results of the Focused Ultrasound Foundation-funded essential tremor Phase I pilot clinical trial at the University of Virginia have led to planning for the next data-gathering step required for regulatory approval: a global, multi-site pivotal Phase III study to evaluate the safety and efficacy of transcranial MR-guided focused ultrasound in treating essential tremor. Device maker InSightec, Ltd., which is sponsoring the study, has obtained U.S. Food and Drug Administration approval for a double-arm protocol and expects as many as eight sites and 72 patients to participate.

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  • New Data Shows Focused Ultrasound Has Positive Effect in Treating Essential Tremor

    April 29, 2013 - University of Virginia neurosurgeon W. Jeffrey Elias reported today that one-year clinical data indicates that essential tremor patients treated with noninvasive transcranial focused ultrasound experienced significant disability reduction and improved quality of life. The research, which was funded by the Focused Ultrasound Foundation and presented at the annual meeting of the American Association of Neurological Surgeons, showed that patients experienced a 67 percent reduction in their dominant hand tremor scores and an 83 percent improvement in their disability scores.

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  • Pioneering Patients Tell the World About Their Focused Ultrasound Treatment

    Many of the 15 patients who participated in the Focused Ultrasound Foundation-funded pilot essential tremor study at the University of Virginia have stepped forward to share their story with the news media. By doing so, they have added a new dimension to the role patient participants play in advancing a promising new medical technology. Their courage and their stories have touched people around the world and spurred interest in using noninvasive sound waves instead of scalpels to treat movement disorders.

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  • Journal of Therapeutic Ultrasound Launched

    The growing field of therapeutic ultrasound welcomes its first open access journal


    Open access publisher BioMed Central is proud to announce the launch of Journal of Therapeutic Ultrasound in partnership with the Focused Ultrasound Foundation and the International Society for Therapeutic Ultrasound.

    Therapeutic ultrasound is a fast growing field and all parties involved believe that having a dedicated open access journal in this area can only speed up the development and eventual adoption of this important clinical tool by the wider medical community.

    Focused ultrasound has the potential to be an alternative or complement for radiation therapy, the means to dissolve blood clots, and a way to deliver drugs in extremely high concentrations to a precise point in the body. It has the potential to treat a variety of serious medical disorders, including cancer, uterine fibroids, essential tremor, Parkinson’s disease, epilepsy, and neuropathic pain.  

    “Focused ultrasound technology has enormous potential to improve the quality of lives for millions around the world,” noted Neal F. Kassell, M.D., Chairman and Founder of the Focused Ultrasound Foundation. “The research reported in the Journal of Therapeutic Ultrasound will be central to advancing the field and will help accelerate the progress of focused ultrasound towards clinical adoption.” 

    Journal of Therapeutic Ultrasound encompasses all aspects of therapeutic ultrasound, namely, the stimulus, inhibition, or modification of tissue function or structure via insonification. Led by Editors-in-Chief Arik Hananel, Focused Ultrasound  Foundation, USA and Robert Muratore, Quantum Now LLC, USA, with an international editorial board consisting of the best in the field of focused ultrasound, this open access, peer-reviewed, online journal focuses mainly on translational and clinical research.

    Deborah Kahn, BioMed Central’s Publishing Director said, "We’re very pleased to welcome the Focused Ultrasound Foundation and the International Society for Therapeutic Ultrasound as new publishing partners to BioMed Central, and we share their excitement in launching the Journal of Therapeutic Ultrasound within our growing list of society journals."

    The launch edition includes two research articles. One looks at the impact of vaporized nanoemulsions on ultrasound-mediated ablation. If these results can be replicated in the clinic, microbubbles could improve the efficiency of high intensity ultrasound treatment of solid tumors. An editorial on ‘The Journal of Therapeutic Ultrasound - broadening knowledge in a rapidly growing field’ by Editors-in-Chief Arik Hananel and Robert Muratore, is also featured. 

    All Article-Processing Charges (APC) for the journal are currently covered by the Focused Ultrasound Foundation.

    Media Contact
    Rebecca Fairbairn
    Public Relations Manager, BioMed Central
    Tel:  +44 (0) 20 3192 2433
    Mob: +44 (0) 7825 257423


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  • Profound Medical Announces Initiation of TULSA Clinical Trial for Treatment of Localized Prostate Cancer

    PMI initiates Transurethral Ultrasound Ablation (TULSA) clinical trial for novel, minimally invasive device for localized prostate cancer treatment 

    TORONTO, April 25, 2013 /CNW/ - Profound Medical Inc. today announced the commencement of its Health Canada approved, multi-center TULSA (Transurethral Ultrasound Ablation) clinical trial for its minimally invasive, novel ablation device used to facilitate prostate cancer treatment. In the world's first procedure of its kind, a patient was treated in a collaborative effort with London Health Sciences Center, Ontario, Western University, and the Lawson's Health Research Institute. The Canadian trial will include the treatment and one-year monitoring of 30 patients with localized prostate cancer. The device presents the potential for significantly improved clinical outcomes and a marked departure from current methods by virtue of its ability to treat the whole gland in one session with unprecedented accuracy and minimal side effects.

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  • Ground-breaking Study Treats Locally Advanced Pancreatic Cancer

    Alessandro Napoli, MD and his colleagues at the University of Roma La Sapienza in Italy are establishing a solid reputation as clinical trail-blazers for focused ultrasound. Their latest clinical study is the first to use MR-guided focused ultrasound to treat patients with unresectable, locally advanced pancreatic cancer. The study, which is expected to enroll 15-20 patients, is exploring the feasibility and clinical performance of MR-guided focused ultrasound ablation in palliating pain and controlling tumors. Four patients have received treatment to date and will be followed for up to 12 months.

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  • Focal Hyperthermia May Improve Treatments of Prostate and Pelvic Diseases

    In contrast to high-intensity focused ultrasound (HIFU), which implies high-power and high-temperatures for short durations, focal HT relies on feedback control to maintain a much lower temperature rise (39-45° C) in larger contiguous regions over timeframes that can range from 15 to 60 minutes.  Chris Diederich, PhD and his colleagues at the University of California San Francisco have a new use in mind for their site’s focused ultrasound device (InSightec’s ExAblate 2100 Prostate System). With a $100,000 research award from the Focused Ultrasound Foundation, they plan to modify the MR-guided ablation system so it can be used to deliver focal hyperthermia (HT) – a therapy that heats up tissue and is known to enhance clinical response to radiation therapy and chemotherapy.

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  • Lancet Neurology Publishes Results of Foundation-funded Essential Tremor Study at Sunnybrook Health Sciences Centre

    The Lancet Neurology has published the early findings of the Focused Ultrasound Foundation-funded essential tremor clinical trial at Sunnybrook Health Sciences Centre in Toronto. The study, which was published online ahead of print, covered four patients treated between May 2012 and January 2013. The MR-guided focused ultrasound treatments, which were designed to impact tremor in one hand, resulted in immediate and sustained tremor improvements. Mean tremor scores decreased by 89.4% at one month and by 81.3% at three months, when the follow-up period concluded. Reported side-effects included post-operative paraesthesias (tingling) in one patient and deep vein thrombosis in another.

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    Due to numerous requests, the abstract deadline has been extended one last time. The deadline for submission will be March 21 at 11:59 PM Pacific Daylight Time US. The abstract review process will be conducted during this time to process abstracts already received so we ask that you please not try to revise these abstracts.  This will provide responses to those authors that submitted previously.  Authors submitting abstracts during this extension period are encourage to submit as soon as possible to obtain a timely review, particularly those requiring travel documentation. Thank you to all those who have submitted their abstracts already and we look forward to a great meeting in Shanghai. 

    Guofeng Shen, Program Committee Chair

    Brian Fowlkes, ISTU Secretary





    13th International Symposium on Therapeutic Ultrasound scheduled for May 12-15 in Shanghai, China.

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