Non-Invasive Treatment of Pediatric Neurological Disorders using MR-guided Focused Ultrasound - Part 1 Pediatric Skull Characterization and Re-Focusing

Project Name: Non-Invasive Treatment of Pediatric Neurological Disorders using MR-guided Focused Ultrasound - Part 1 Pediatric Skull Characterization and Re-Focusing
Status: Complete
Primary Site: Hospital for Sick Children
Sponsor Organization: Focused Ultrasound Foundation
Funded Date: Jul 01, 2014
Funding Program: Research Award
Funding Period: Jul 01, 2014 - Jun 30, 2015
Amount Awarded: $100,000.00
Category: Brain, General

Abstract

The concept of brain lesioning is well established in adult tremor and early results from MRgFUS trials have shown great efficiacy. In addition, work has been done to show that is possible to target and ablate tumors with transcranial systems. However, there is little to no work performed on neonatal and pediatric patients. Based on clinical presentation of IVH and epilepsy, there is a clear clinical need for non-invasive treatments as current treatment techniques have complications (eg. secondary intracerebral hemorrhages from tPA). With our initial data, neonatal and pediatric patients possess unique skull and brain properties that facilitate and simplify the transmission of focused ultrasound. The open fontanelle and thinner skulls potentially reduce the need for lower frequencies which opens up the possibility of using existing MRgFUS transducers to perform the treatment and reduce the upfront investments. Our project will characterize the acoustic properties of pediatric skulls over 3 frequencies, develop a refocusing algorithm based on the acoustic data, simulate the acoustic transmission through the skull to study the effects on the target and surrounding areas and validate the algorithm on a porcine model.

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