University of Virginia Health System

337 Crispell Dr.

Charlottesville, VA 22908

United States

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Primary Contact: Richard J Price

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Research Areas

Pre-Clinical	Clinical	Technical	Bioeffect
None	Breast Tumors, Benign Melanoma Epilepsy Essential Tremor Breast Tumors, Malignant Cervical Tumors Lung Tumors Ovarian Tumors Glioblastoma Cancer Pain Multiple Tumors Gastric Tumors Esophageal Tumors	Drug Delivery Technology FUS Image Guidance, MR FUS Treatment Monitoring FUS Image Guidance, Ultrasound	Nonthermal - Clot Lysis Nonthermal - Sonodynamic Therapy Nonthermal - BBB Opening Drug Delivery Nonthermal - BBB Opening Nonthermal - Drug Delivery Vehicle Hyperthermia - Drug Delivery Nonthermal - Immune Cell Trafficking Nonthermal - Tissue Destruction Nonthermal - Sonoporation Nonthermal - Stem Cell Trafficking Nonthermal - Immunomodulation Nonthermal - Stem Cell Delivery Nonthermal - Neuromodulation Nonthermal - Vascular Occlusion Histotripsy - Tissue Destruction Thermal Ablation - Tissue Destruction Nonthermal - Drug Delivery Nonthermal - Angiogenesis Nonthermal - Drug Delivery Immunotherapeutic

Researchers

Research Projects Funded by the Focused Ultrasound Foundation

Category	Title	Indication	Status
Clinical Research	Focused Ultrasound Therapy to Augment Antigen Presentation and...	Breast Tumors, Malignant	Active
Technical	Targeted Delivery of Controlled Release Nanoparticles to Brain Tumors Using...	Brain Tumors, General	Complete
Pre-Clinical	A Radiographic and Histologic Comparison Between Radiofrequency, Gamma Knife...	Essential Tremor	Complete
Pre-Clinical	A safety and feasibility study of MR-guided focused ultrasound lesioning in the...	Essential Tremor	Complete
Pre-Clinical	Delivery of Brain Tumor-Penetrating Nanoparticles Across the Blood Brain...	Brain Tumors, General	Complete
Technical	Real-time 3D MR Thermometry for Focused Ultrasound Surgery		Complete
Pre-Clinical	Use of low-intensity focused ultrasound for the non-invasive, focal...	Epilepsy	Active
Technical	Development of Novel Acoustic Coupling Media to Improve Image Guidance and...		Complete
Pre-Clinical	Enhancing Neurogenesis by Focused Ultrasound-mediated Plasmid Delivery	Alzheimer's Disease	Active
Clinical Research	A Feasibility Study to Evaluate Safety and Initial Effectiveness of ExAblate...	Essential Tremor	Complete
Pre-Clinical	Sonodynamic therapy for treatment of C6 glioma in a rat model proof-of-concept...	Glioblastoma	Complete
Pre-Clinical	Focused ultrasound radiosensitization of brain tumors	Brain Tumors, General	Active
Pre-Clinical	Non-Invasive Surgical Treatment of Lung Cancer	Lung Tumors	Active
Pre-Clinical	Transcranial MRI Guided Focused Ultrasound Surgery for Intracerebral Hemorrhage	Stroke, Intracerebral Hemorrhage	Complete
MOA	In vivo transcranial cavitation study of low-frequency focused ultrasound in...		Complete
Pre-Clinical	Sonodynamic therapy for treatment of C6 glioma in a rat model – Step 1: F...	Glioblastoma	Complete
Pre-Clinical	Sonodynamic therapy for treatment of C6 glioma in a rat model – Step 2: P...	Glioblastoma	Complete
Technical	Thermal Dose Experiment in a Pig Model		Complete
Pre-Clinical	A Chronic Pig Study of Transcranial Histotripsy for Treatment of Brain Tumors	Brain Tumors, General	Complete
Pre-Clinical	Microvascular Ablation of Intracranial Gliomas with Focused Ultrasound (F98...	Brain Tumors, General	Active
Pre-Clinical	Safety study: sonodynamic therapy with 5-ALA in a porcine model	Glioblastoma	Complete
Pre-Clinical	Focused Ultrasound Treatment of Cerebral Cavernous Malformations	Cerebral Cavernous Malformations	Active
Technical	MR Visualization of Arterial Thrombus	Stroke, Intracerebral Hemorrhage	Complete
Technical	Target-Specific FUS Treatment Envelope Survey in Cadaveric and Ex-Vivo...	Epilepsy	Complete
Technical	Development and Calibration of MR Techniques for In-Vivo Bone Thermometry		Complete
Technical	Real-time Treatment Monitoring by Diffusion MRI		Complete
Technical	MRI Guidance of Focused Ultrasound Neurosurgery		Active
Technical	MRI of Skull Heating During Focused Ultrasound Neurosurgery		Active
Technical	MR Bone Imaging		Complete
Technical	Imaging Atlas of Clot	Stroke, Intracerebral Hemorrhage	Complete
Pre-Clinical	Enhancing immune therapy for brain metastases with focused ultrasound	Melanoma	Complete
Pre-Clinical	Ultrasound-induced immune response on breast cancer	Breast Tumors, Malignant	Complete
Pre-Clinical	Focused ultrasound immunomodulation for pancreatic cancer	Pancreatic Tumors, Malignant	Active
Pre-Clinical	Ultrasound-guided gene delivery to brain tumors	Brain Tumors, General	Active
Pre-Clinical	Focused Ultrasound Immunomodulation in a Mouse GL261 Intracranial Glioma	Glioblastoma	Complete
Clinical Research	A feasibility Study to Evaluate Safety and Initial Effectiveness of ExAblate...	Parkinson's Disease, Dyskinesia	Complete
Clinical Research	A Feasibility Study to Evaluate Safety and Initial Effectiveness of ExAblate...	Parkinson's Disease, Tremor	Complete

Alan H Matsumoto	Alexander L Klibanov	Amber L Shada	Andrew Y Wang
Benjamin Messinger	Brian H Annex	Brian Wispelwey	Bruce G Bateman
Bryan G Sauer	Carrie Rochman	Christopher Kramer	Craig Meyer
Dana Redick	Daniel E Kleiner	David J Schlesinger	David R Brenin
David Shonka	Diane Huss	George S Bloom	Jaime F Mata
James M Larner	James R Stone	Jason P Sheehan	JoAnn V Pinkerton
Jody Reyes	John A Hossack	John Gaughen	Kelli Reardon
Leigh B Grossman	Lynn R Kohan	Mary E Jensen	Michael Keng
Michelle Barr	Mohamad A Khaled	Nicholas J Tustison	Nina Solenski
Noah S Schenkman	Paul W Read	Pearl L Yu	Peyton T Taylor Jr.
Raymond F Morgan	Reid B Adams	Richard J Price	Robert C Frysinger
Roger Abounader	Sharon L Hostler	Shiv R Khandelwal	Steven Wasserman
Vanessa M Shami	William Jeff Elias	Zhiyuan Xu