FUS-mediated Neuromodulation from Unanesthetized Freely-moving Animals

Project Name: FUS-mediated Neuromodulation from Unanesthetized Freely-moving Animals
Status: Complete
Primary Site: Brigham and Women's Hospital
Sponsor Organization: Focused Ultrasound Foundation
Funded Date: Sep 01, 2016
Funding Period: Sep 01, 2016 - Aug 31, 2020
Funding Program: Research Award
Category: MOA
Amount Awarded: $700,000.00


The goal of the proposed research is to implement and apply non-thermal transcranial focused ultrasound (FUS) to the somatomotor area (SM1) of unanesthetized, freely- moving, awake small animals (rats). We will examine the neuromodulatory outcome based on electrophysiological signals and motor behavioral responses to the sonication. The safety profile of the sonication will also be evaluated through immunohistological analysis and behavioral monitoring. The investigation of FUS neuromodulatory effects in awake animals will be essential for assessing the success rate and reproducibility of stimulation, without the confounding effects of anesthesia.

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