Advances in cancer immunotherapy have improved our understanding of how to use the immune system against the disease. Pancreatic cancer presents unique challenges because of limited immune cell infiltration. HIFU can induce necrosis on target tissue by raising temperature to ablative levels. In addition HIFU may create cavitation which can result in mechanical disruption of stroma surrounding cancer cells. The aim of this study is to expose pancreatic cancers to HIFU in order to increase T cell infiltration in the tumour. Then treatment with anti-CTLA-4 and anti-PD-1 antibodies aims to activate the infiltrated T cells to exert their anti-tumour response.