The recent success of immunotherapies in cancers such as melanoma has spurred interest in the application of these therapies for other cancers. Glioblastoma (GBM) affects an estimated 18,500 patients annually, and there are approximately 15,000 deaths per year from GBM in the US. GBM is a highly invasive and diffuse tumor, commonly occurring in white matter. There are no clear margins between tumor and brain tissue, which makes full surgical resection impossible. 90% of patients develop tumor recurrence at or near the surgical site. Recent work has demonstrated that immunotherapies can have a beneficial effect in mouse models of GBM and metastatic brain cancer. This effect could be augmented by using focused ultrasound to increase the immunogenicity or accessibility of the tumors, thereby increasing the infiltration and/or activity of anti-tumor immune cells. In this study we want to investigate the effects of different focused ultrasound modalities on the immune system. Each of these modalities will be investigated by a site with expertise in the field
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