Ultrasound-mediated delivery of siRNA for enhancing temozolomide efficacy against glioblastoma

Project Name: Ultrasound-mediated delivery of siRNA for enhancing temozolomide efficacy against glioblastoma
Status: Complete
Primary Site: Boston University
Sponsor Organization: Focused Ultrasound Foundation
Funded Date: Jun 01, 2016
Funding Period: Jun 01, 2016 - Dec 15, 2017
Funding Program: Research Award
Category: Pre-Clinical
Amount Awarded: $100,000.00

Abstract

An appealing strategy for treating primary brain tumors is to block the synthesis of proteins actively involved in the growth and chemoresistance of the disease with small interfering RNA (siRNA). However, the blood-tumor barrier (BTB) impedes the delivery of siRNA to target cancer cells. When combined with ultrasound contrast agents, focused ultrasound can reversibly open the BTB, thus providing a pathway for circulating siRNA delivery vehicles to reach brain cancer cells. The goals of this project are to investigate the proposed siRNA delivery strategy and to examine the impact of siRNA-induced oncogene silencing on primary brain cancer growth and chemoresistance.

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