Noninvasive targeted neuromodulation and functional imaging in behaving macaques

Project Name: Noninvasive targeted neuromodulation and functional imaging in behaving macaques
Status: Complete
Primary Site: Vanderbilt University
Sponsor Organization: Focused Ultrasound Foundation
Funded Date: Sep 23, 2015
Funding Program: Research Award
Funding Period: Sep 23, 2015 - Jun 30, 2018
Amount Awarded: $1,316,458.00
Category: Brain, General

Abstract

All presently available neural stimulation methods are either invasive or can only be moderately localized, and a neurostimulation method that could overcome these limitations would be invaluable for the mapping of brain circuits, disease diagnosis in the brain, neurosurgery and therapy. Neural stimulation with magnetic resonance guided focused ultrasound (MRgFUS) is a promising technology that can noninvasively excite or inhibit neural activity in well-defined discrete volumes of the brain, subsequently enabling investigation of brain circuits with magnetic resonance imaging (MRI). In this study, we seek to explore ultrasonic neuromodulation in the frontal eye field of a macaque monkey, while measuring the effects of neuromodulation via eventrelated potentials, behavioral responses, and blood oxygen level dependent functional MRI.

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