Sonodynamic therapy for treatment of C6 glioma in a rat model – Step 1: Feasibility of tumor model

Project Name: Sonodynamic therapy for treatment of C6 glioma in a rat model – Step 1: Feasibility of tumor model
Status: Complete
Primary Site: University of Virginia Health System
Sponsor Organization: Focused Ultrasound Foundation
Funded Date: Jun 03, 2014
Funding Period: Jun 03, 2014 - Sep 03, 2014
Funding Program: Brain Program
Category: Pre-Clinical
Amount Awarded: $13,538.38

Abstract

For many patients with intracranial tumors, there is a need for a safer and more effective treatment modality that is non-invasive, deep-penetrating, and less prone to infection and damage to surrounding tissues. Sonodynamic therapy (SDT) has been shown to induce apoptosis of tumor cells when used in conjunction with various sonosensitizers. The aim of this initial study is to determine whether the sonosensitizers 5-ALA and IcG can be effectively delivered to the subcutaneous C6 glioma rat model (a readily available model). If this initial study is successful, a proof-of-concept study of ultrasound-induced hyperthermia (low-level heating) as a means to activate 5-ALA and IcG to cause cell death will be completed. Finally, a larger study will be completed to compare the effectiveness of these sonosensitizers, identify a “best” sonosensitizer, and further optimize ultrasound parameters including frequency, which could ultimately help move this work towards a clinical trial

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