FUS-mediated Functional Neuromodulation for Neurophysiologic Assessment in a Large Animal Model

Project Name: FUS-mediated Functional Neuromodulation for Neurophysiologic Assessment in a Large Animal Model
Status: Complete
Primary Site: Brigham and Women's Hospital
Sponsor Organization: FUSF Research Awards Committee
Funded Date: Jun 01, 2013
Funding Period: Jun 01, 2013 - May 31, 2014
Funding Program: Research Award
Category: MOA
Amount Awarded: $100,000.00

Abstract

The goal of the proposed research is to investigate the method of using MR imageguided transcranial focused ultrasound (FUS) to reversibly modulate (i.e. elicit and suppress) the activity of a region-specific brain area in large animals (sheep). Electrophysiological representations resulting from the modulation will be assessed in terms of visual, somatosensory, and motor function. After the sonication, the safety profiles of the sonication will be examined through anatomical MRIs and histological analysis. The non-invasive neuromodulation of deep brain function and concurrent neurophysiologic assessment will be essential for mapping and confirmation of the treatment areas prior to FUS-mediated functional neurosurgery

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