Nanoagents for improving focused ultrasound thermal delivery to tumors with imaging feedback

Project Name: Nanoagents for improving focused ultrasound thermal delivery to tumors with imaging feedback
Status: Complete
Primary Site: University of North Carolina at Chapel Hill
Funded Date: Jul 01, 2013
Funding Period: Jul 01, 2013 - Dec 15, 2014
Funding Program: Research Award
Category: Technical
Amount Awarded: $100,000.00

Abstract

We have developed a unique metastable nanodroplet formulation which data suggests 1) will improve thermal delivery efficiency of intensity focused ultrasound (HIFU) ablation in vivo, and 2) will improve the spatial distribution of thermal delivery at the acoustic focus, without near-field attenuation or heating. In this project, we will test and optimize our approach by quantifying nanodroplet dose and improvements in thermal delivery efficiency in vivo using MRgFUS; assessing long term circulation in vivo; and by performing MRgFUS in vivo studies in rodent tumor model to validate nanodropletenhanced HIFU treatment of tumors, compared to sham controls. Finally, we will perform histology to assess tissue for collateral bioeffects.

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