Detection and Characterization of Intracranial Cavitation Activity

Project Name: Detection and Characterization of Intracranial Cavitation Activity
Status: Complete
Primary Site: University of California, San Diego School of Medicine
Sponsor Organization: Focused Ultrasound Foundation
Funded Date: Aug 01, 2011
Funding Period: Aug 01, 2011 - Jul 31, 2012
Funding Program: Brain Program
Category: Technical
Amount Awarded: $100,000.00


The goal of this project is to optimize an extracranial passive cavitation detection (EC-PCD) capability, and, using an in vitro model of human skull & brain, reliably characterize cavitation and determine the effects of different skull anatomy on both cavitation activity and the ability to detect it. The EC-PCD capability of the ExAblate 4000 will be compared to an intracranial (IC) PCD system, using microbubble-containing flow tubes in human calvaria, progressing to brain-mimicking material (BMM) in calvaria and finally BMM in full skulls. This project will lay the necessary groundwork and establish feasibility for a variety of subsequent studies, which include cavitation localization and eventual control of cavitation activity.

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