MR Bone Imaging

Project Name: MR Bone Imaging
Status: Complete
Primary Site: University of Virginia Health System
Sponsor Organization: Focused Ultrasound Foundation
Funded Date: Aug 20, 2010
Funding Period: Aug 20, 2010 - Aug 19, 2011
Funding Program: Brain Program
Category: Technical
Amount Awarded: $40,666.00


Presently, thin-slice CT of the skull is required to collect the information necessary for calculating the transcranial MRgFUS aberration correction. This information includes thickness of the skull, average CT density of the skull, and thickness of the inner and outer table and of the diploe. However, in a number of conditions that could benefit from MRgFUS treatment, such as stroke, the necessity of obtaining a CT of the skull prior to the MRgFUS represents a significant loss of time and a severe drawback. Obtaining the information required for refocusing from an MRI scan would greatly benefit the patients. Also, more generally, patients may move during the course of a MRgFUS treatment, and it may be helpful to be able to rescan the patient and re-plan the refocusing during the course of the MRgFUS treatment (where registration with the skull CT may be less practical or less accurate). MRI has been used extensively for bone imaging of the tibia and radius, in the hope of developing an alternative, non X-ray-based technology to assess bone mineral density and detect osteoporosis in the elderly population. In this study, we will apply the same validated imaging MRI sequences and assess whether they allow to collect information comparable to CT for MRgFUS refocusing.

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