Hypoxia-directed Magnetic Resonance-guided Focused Ultrasound Therapy

Project Name: Hypoxia-directed Magnetic Resonance-guided Focused Ultrasound Therapy
Status: Complete
Primary Site: University of Arkansas for Medical Sciences
Sponsor Organization: Focused Ultrasound Foundation
Funded Date: Aug 01, 2011
Funding Period: Aug 01, 2011 - Jan 31, 2013
Funding Program: Research Award
Category: Pre-Clinical
Amount Awarded: $100,000.00

Abstract

Compelling clinical and experimental evidence clearly indicates that tumor hypoxia remains a challenge for radiation and chemotherapy. The general consensus is that tumor hypoxia is a major cause of treatment failures. We therefore hypothesize that it would be beneficial to detect the hypoxic areas in tumors and irreversibly ablate them to reduce hypoxia related resistance. To test this hypothesis, we propose preclinical studies using a mouse tumor model and PET/MRI guidance to thermally ablate hypoxic-tissue prior to ionizing radiation. In humans, this approach may significantly shorten focused ultrasound thermal ablation treatment times since only hypoxic regions of tumors are targeted.

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