Targeted Delivery of Controlled Release Nanoparticles to Brain Tumors Using Contrast Agent Microbubbles and High-Intensity Focused Ultrasound

Project Name: Targeted Delivery of Controlled Release Nanoparticles to Brain Tumors Using Contrast Agent Microbubbles and High-Intensity Focused Ultrasound
Status: Complete
Primary Site: University of Virginia Health System
Sponsor Organization: Focused Ultrasound Foundation
Funded Date: Sep 01, 2007
Funding Period: Sep 01, 2007 - Aug 31, 2008
Funding Program: Research Award
Category: Technical
Amount Awarded: $100,000.00

Abstract

High-Intensity Focused Ultrasound (HIFU) treatment of brain tumors is complicated by heating of the skull. Here, our goal is to overcome this limitation by developing an ultrasound-microbubble-based therapeutic approach that complements HIFU by mechanically-damaging tumor tissue, occluding blood flow, and depositing 5-FU bearing controlled-release nanoparticles into brain tumors at reduced power levels. Experiments for monitoring nanoparticle delivery, blood flow changes, and tumor regression will be performed using tumors implanted in mouse dorsal skinfold window chambers. We anticipate these that studies will result in the successful development of a delivery method and agent(s) suitable for preclinical testing with HIFU.

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