A Radiographic and Histologic Comparison Between Radiofrequency, Gamma Knife Radiosurgery, and Focused Ultrasound Lesions in Brain

Project Name: A Radiographic and Histologic Comparison Between Radiofrequency, Gamma Knife Radiosurgery, and Focused Ultrasound Lesions in Brain
Status: Complete
Primary Site: University of Virginia Health System
Sponsor Organization: Focused Ultrasound Foundation
Funded Date: Dec 01, 2010
Funding Period: Dec 01, 2010 - Feb 28, 2012
Funding Program: Research Award
Category: Pre-Clinical
Amount Awarded: $164,748.00

Abstract

Stereotactic lesions in brain are an established treatment for certain movement disorders. Focused ultrasound technology may produce more precise intracerebral lesions with less hemorrhage, edema, and damage to the perilesional tissue than existing procedures. We propose to use MR imaging and histology at different time intervals to assess and compare the thalamic lesions in pigs produced by radiofrequency electrodes, gamma knife radiosurgery, and focused ultrasound.

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