Image-Guided Drug Delivery to Tumors using Ultrasound-Activated Perfluorocarbon Nanoemulsions as Drug Carriers

Project Name: Image-Guided Drug Delivery to Tumors using Ultrasound-Activated Perfluorocarbon Nanoemulsions as Drug Carriers
Status: Complete
Primary Site: University of Utah
Sponsor Organization: Focused Ultrasound Foundation
Funded Date: Apr 15, 2011
Funding Period: Apr 15, 2011 - Jul 15, 2012
Funding Program: Research Award
Category: Technical
Amount Awarded: $99,967.00

Abstract

It is still not known which mode of ultrasound action - thermal or mechanical - plays the predominant role in ultrasound mediated drug delivery. This project will combine results from two powerful imaging modalities, MRI and RFP imaging, to better understand and quantify the major effects. Several experimental variables will be tested in vivo using RFP-transfected pancreatic cancer MiaPaCa2 subcutaneous tumors grown in nude mice, providing information to better understand the mechanisms involved in ultrasound-mediated drug delivery.

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