Creation and validation of a clinically-relevant ultrasound-enhanced drug delivery strategy— finalize ultrasound parameters, quantify full body biodistribution and characterize tissue changes

Project Name: Creation and validation of a clinically-relevant ultrasound-enhanced drug delivery strategy— finalize ultrasound parameters, quantify full body biodistribution and characterize tissue changes
Status: Complete
Primary Site: University of California, Davis
Sponsor Organization: Focused Ultrasound Foundation
Funded Date: Jul 01, 2016
Funding Period: Jul 01, 2016 - Jun 30, 2021
Funding Program: Research Award
Category: Technical
Amount Awarded: $3,180,000.00

Abstract

We have observed that low-mechanical index ultrasound can enhance drug accumulation and transport in a clinically-relevant protocol and have devised systems to precisely quantify full-body biodistribution of drugs before and after ultrasound and to precisely control the ultrasound parameters and the resulting heating. We will combine these methods to optimize the ultrasound dose, to quantify the resulting biodistribution of drug and to assess efficacy.

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