The Effect of Focused Ultrasound Ablation on Adjacent Nerve Function

Project Name: The Effect of Focused Ultrasound Ablation on Adjacent Nerve Function
Status: Complete
Primary Site: Brigham and Women's Hospital
Sponsor Organization: Focused Ultrasound Foundation
Funded Date: Sep 01, 2007
Funding Period: Sep 01, 2007 - Sep 01, 2008
Funding Program: Research Award
Category: Pre-Clinical
Amount Awarded: $100,000.00


The goal of this work will be to investigate the safety of ablating tissue with focused ultrasound adjacent to peripheral nerves or to nerve tracts in the brain. We propose experiments in which we ablate tissue adjacent to the sciatic nerve and the optic nerve/tract in the brain and then evaluate nerve function. These experiments are motivated by two promising targets for focused ultrasound treatment where critical nerve structures need to be protected: prostate cancer and brain tumors. If successful, this work will allow good surgical margins, thereby improving the effectiveness of focused ultrasound surgery and reducing local recurrence.

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