Tests of microbubble-enhanced ablation in a large animal model with a low-frequency, transcranial MR-guided focused ultrasound system

Project Name: Tests of microbubble-enhanced ablation in a large animal model with a low-frequency, transcranial MR-guided focused ultrasound system
Status: Complete
Primary Site: Brigham and Women's Hospital
Sponsor Organization: Focused Ultrasound Foundation
Funded Date: Oct 01, 2011
Funding Period: Oct 01, 2011 - Dec 31, 2012
Funding Program: Research Award
Category: Pre-Clinical
Amount Awarded: $112,002.00

Abstract

This study will test transcranial microbubble-enhanced thermal ablation in the brain in a large animal model using a low-frequency transcranial MR-guided focused ultrasound system. We aim to show that this ablation does not damage non-targeted areas or cause delayed effects. We will also measure cavitation thresholds and examine the ablation in MRI and histology. This ablation method has the potential to increase the regions in the brain that can be targeted by focused ultrasound, but safety concerns need to be addressed using a realistic animal model.

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