Parkinson’s disease (PD) is the second most common neurodegenerative disease. Although numerous potential disease-modifying therapeutics have been proposed, these are typically limited from entering the brain by the blood-brain barrier (BBB). To date, approaches to overcome the BBB, such as convection enhanced delivery, have relied on open surgery, and it’s inherent risks. MR-guided focused ultrasound (MRgFUS) is an incisionless, emerging approach for drug delivery that temporarily permeabilizes the BBB, the enhanced delivery of compounds delivery intravascularly. This can be achieved without surgery, and in a targeted fashion to deep parts of the brain involved in PD pathology. We are investigating whether MRgFUS induced BBB opening is safe and feasible in human PD patients, to determine it’s role as a drug delivery tool for PD.
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