Enhancing Neurogenesis by Focused Ultrasound-mediated Plasmid Delivery

Project Name: Enhancing Neurogenesis by Focused Ultrasound-mediated Plasmid Delivery
Status: Active
Primary Site: University of Virginia Health System
Funded Date: Nov 06, 2020
Funding Period: Nov 06, 2020 - Nov 05, 2021
Funding Program: Research Award
Category: Pre-Clinical
Amount Awarded: $100,000.00

Abstract

It has been proposed that focused ultrasound (FUS) could be used to stimulate neurogenesis. Low-energy FUS and intravenously administered cationic microbubbles (MB) conjugated with plasmid DNA can deliver specific gene expression to the endothelial cells without the hazards of viral infection, blood-brain barrier disruption or neuroinflammation. Here, we will evaluate the feasibility and efficiency of FUS/MB-mediated delivery of canonical Wnt ligands in the vasculature of subgranular zone in the dentate gyrus. To this end, we will determine whether this approach will increase basal neurogenesis in the aging hippocampus.

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