It has been proposed that focused ultrasound (FUS) could be used to stimulate neurogenesis. Low-energy FUS and intravenously administered cationic microbubbles (MB) conjugated with plasmid DNA can deliver specific gene expression to the endothelial cells without the hazards of viral infection, blood-brain barrier disruption or neuroinflammation. Here, we will evaluate the feasibility and efficiency of FUS/MB-mediated delivery of canonical Wnt ligands in the vasculature of subgranular zone in the dentate gyrus. To this end, we will determine whether this approach will increase basal neurogenesis in the aging hippocampus.
No reports found.