Advances in immunotherapy have revolutionized the treatment of cancer, providing cures to patients with previously lethal disease. Sadly, clinical trials of currently established immunotherapies have not provided therapeutic benefit to pancreatic cancer patients. For this reason, alternative immunotherapeutic approaches are needed. Oncolytic viruses represent one form of immunotherapy. These viruses infect and kill cancer cells while leaving normal tissue unharmed. We and others have tested their ability to treat some forms of cancer, including brain and skin tumours, but their use in pancreatic cancer has not been fully validated yet, partly due to the low infection rates they exhibit.
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